The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish

Aragona, Marialuisa; Porcino, Caterina; Guerrera, Maria Cristina; Montalbano, Giuseppe; Laurà, Rosaria; Cometa, Marzio; Levanti, Maria; Abbate, Francesco; Cobo, Teresa; Capitelli, Gabriel; Vega, J.A.; Germanà, Antonino

doi:10.3390/ijms23052621

Cited by 23 publications

(19 citation statements)

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“…A previous study on zebrafish showed the presence of TrkA and TrkB/BDNF in sensory cells of taste buds [29,30]. In view of this, a local action in zebrafish taste buds could be supposed for NGF as well as for BDNF/NT4 detected in the present study for TrkA and TrkB positive cells, respectively, probably through a paracrine/autocrine mechanism.…”

Section: Discussionsupporting

confidence: 69%

“…In fish, neurotrophins are widely represented in the brain [11][12][13][14][15][16][17][18][19] and sensory organs such as the retina [20][21][22][23][24], inner ear, lateral line and olfactory organ [25][26][27]. Previous studies in fish demonstrated the presence of neurotrophin receptors in taste buds (TBs), namely the common Trk amino acid sequence in sea bass [28], while TrkB and TrkA have been reported in zebrafish (Danio rerio) [27,29,30], thus suggesting the sensibility of fish TBs to neurotrophins.…”

Section: Introductionmentioning

confidence: 99%

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Neurotrophins in Zebrafish Taste Buds

Gatta

Schiano

Attanasio

et al. 2022

Animals

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The neurotrophin family is composed of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), Neurotrophin 3 (NT3) and NT4. These neurotrophins regulate several crucial functions through the activation of two types of transmembrane receptors, namely p75, which binds all neurotrophins with a similar affinity, and tyrosine kinase (Trk) receptors. Neurotrophins, besides their well-known pivotal role in the development and maintenance of the nervous system, also display the ability to regulate the development of taste buds in mammals. Therefore, the aim of this study is to investigate if NGF, BDNF, NT3 and NT4 are also present in the taste buds of zebrafish (Danio rerio), a powerful vertebrate model organism. Morphological analyses carried out on adult zebrafish showed the presence of neurotrophins in taste bud cells of the oropharyngeal cavity, also suggesting that BDNF positive cells are the prevalent cell population in the posterior part of the oropharyngeal region. In conclusion, by suggesting that all tested neurotrophins are present in zebrafish sensory cells, our results lead to the assumption that taste bud cells in this fish species contain the same homologous neurotrophins reported in mammals, further confirming the high impact of the zebrafish model in translational research.

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Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Neurotrophins in Zebrafish Taste Buds

Gatta

Schiano

Attanasio

et al. 2022

Animals

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“…It can promote the growth of neurons, promote the formation and stability of neuronal synapses, as well as promote long-term potentiation . A previous study found that BDNF as well as its receptor TrkB was reduced in patients with depression . BDNF knockout in the DG leads to depression-like behaviors .…”

Section: Discussionmentioning

confidence: 99%

“…45 A previous study found that BDNF as well as its receptor TrkB was reduced in patients with depression. 46 BDNF knockout in the DG leads to depression-like behaviors. 47 In vivo perfusion of hippocampal BDNF can induce antidepressant effects in depressive animals.…”

Section: ■ Discussionmentioning

confidence: 99%

CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice

Wang

Liu

Zhang

et al. 2022

ACS Chem. Neurosci.

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Depression is a serious mental illness, mainly characterized as large mood swings and sleep, diet, and cognitive function disorders. NLPR3, one of the inflammasomes that can be activated by a variety of stimuli to promote the maturation and secretion of pro-inflammatory cytokines, has been considered to be involved in the pathophysiology of depression. In this study, the putative role of CY-09, a selective and direct inhibitor of NLRP3, was evaluated in the lipopolysaccharide (LPS)-induced mice. The results of the study indicated that CY-09 significantly decreased the levels of NLRP3 in the hippocampus of LPS-induced mice. In addition, CY-09 increased the sucrose preference and shortened the immobility time in LPS-induced mice, suggesting the antidepressant-like effects of inhibiting NLRP3 inflammasome. Biochemical analysis showed that LPS significantly activated the NLRP3/ASC/cytokine signaling pathway and caused microglial activation, while CY-09 prevented the changes. Moreover, CY-09 increased the brain-derived neurotrophic factor (BDNF) only in microglia but not in the whole hippocampus. Meanwhile, CY-09 did not promote neurogenesis in the hippocampus of LPS mice. In conclusion, the results of the study showed that the antidepressant-like effects of NLRP3 inhibitor CY-09 were mediated by alleviating neuroinflammation in microglia and independent of the neurotrophic function in the hippocampus.

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“…The receptors of the nerve growth factor are of two types: low-a nity nerve growth factor (p75NTR, also referred to as NGFR) and high-a nity tyrosine kinase receptor (TrkA) [11]. NGFR has a relatively simple structure and interacts non-speci city with four neurotrophic factors, namely, NT-4, NT-3, Brain-Derived Neurotrophic Factor (BDNF), and Nerve Growth Factor (NGF) [12]. NGFR performs a positive regulatory function in cell survival and proliferation in synergy with TrkA while promoting apoptosis in the absence of TrkA.…”

Section: Introductionmentioning

confidence: 99%

NGF-NGFR communication inefficiency induces T Cell exhaustion impairing PD-1 immunotherapy in hepatocellular carcinoma

Yang

et al. 2023

Preprint

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The number of T cells that infiltrate tumor tissues in hepatocellular carcinoma (HCC) is significantly low. The molecular mechanism underlying T cell proliferation in tumor tissues is poorly understood. The present study revealed that during the process of T cell infiltration from adjacent tissues to tumor tissues, the NGF-NGFR communication inefficiency occurred in the tumor tissues of HCC patients. Importantly, the tumor cell-secreted NGF interacted with NGFR on the membranes of the infiltrated T cells, which promoted proliferation of these cells through mitotic spindle signal activation. Mechanistically, the mitotic spindle signal activation promoted the proliferation was mediated by the HDAC1 unclear trans-localization-inhibited PREX1 expression. Further, PD-1 mAb acted synergistically with the NGF-NGFR communication to suppress tumor progression in both mouse model and HCC patients. In addition, NGF–NGFR communication was positively correlated with the PD-1/PDL-1 expression. However, NGF and NGFR expressions were low in tumor tissues, which was responsible for the incursive clinicopathological features and the disappointing prognosis in HCC patients. Collectively, the results suggested that NGF-NGFR communication inefficiency impaired PD-1 mAb immunotherapy and could, therefore, be utilized as a novel therapeutic target in the treatment of HCC patients in clinical practice.

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The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish

Cited by 23 publications

References 131 publications

Neurotrophins in Zebrafish Taste Buds

Neurotrophins in Zebrafish Taste Buds

CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice

NGF-NGFR communication inefficiency induces T Cell exhaustion impairing PD-1 immunotherapy in hepatocellular carcinoma

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