The BCR/ABL hybrid gene

Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions.

“…The same ber-abl provirus insert as in the primary mouse was found in day-14 mixed myeloid spleen VOL. 12,1992 on May 12, 2018 by guest http://mcb.asm.org/ colonies from one secondary recipient of bone marrow cells (5) and in the T-cell leukemia arising in a secondary recipient of bone marrow cells from another mouse with granulocytic disease (6). Since CML is a stem cell disease, multipotential cells may be the only targets in which ber-abl expression leads to a disease with a predominantly myeloid phenotype.…”

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia

“…In contrast, minor BCR, involving a breakpoint between exons 1 and 2 of BCR, encodes a 190-kDa-fusion protein. This latter fusion is observed in 90% of BCR-ABL1-positive pediatric BCP-ALL [92][93][94]. Fusion of the BCR signaling protein with the ABL nonreceptor tyrosine kinase results in a constitutive tyrosine kinase activity, activating multiple signaling pathways, increasing cell proliferation, and deregulating differentiation and adhesion [95].…”

Chronic myelogenous leukemia: mechanisms underlying disease progression

“…16,17 In this translocation, the c-ABL proto-oncogene is transposed from its normal position on chromosome 9 to a 5.8 kb major breakpoint cluster region M-BCR on chromosome 22, forming a BCR-ABL fusion gene. 17,18 The new gene encodes p210 BCR/ABL , an oncoprotein that has increased tyrosine kinase (TK) activity 19,20 and increased binding to the actin cytoskeleton 21 compared with the p145 Abelson protein, both of which contribute to transformation. The presence of p210 BCR/ABL causes growth factor independence and leukemic cell growth in hematopoietic cell lines.…”