The Granada and Guadix-Baza Basins, the largest Neogene-Quaternary intramontane basins of the Betic Cordillera (southern Spain), undergo active deformation with an associated moderate level of seismic activity. This deformation is controlled by a NNW-SSE compressive regime and an approximate orthogonal tensional regime. The compression produced N70ºE to E-W folds of several scales, the Sierra Nevada antiform being the largest one. The tension is accommodated mainly by NW-SE active normal faults, the most notable being the Baza Fault, in the Guadix-Baza Basin, and the Granada, Sierra Elvira-Dílar and Padul-Dúrcal Faults, in the Granada Basin. In addition, other active faults with different orientations also exist, such as the Alfahuara-Botardo and the Galera faults in the Guadix-Baza Basin, and the Huenes, Obéilar-Pinos Puente and N of Sierra Tejeda Faults in the Granada Basin. Moreover, in several sectors, the presence of orthogonal normal fault sets suggests alternating trends or even radial extension. Slip rates of these active faults, based on geologic markers, vary between 0.06 and 0.5 mm/year. Estimates for the maximum expected magnitude of earthquakes caused by these faults vary between M W 6.0 and 7.0. The N of Sierra Tejeda and the Baza Faults, the larg-ISSN (print): 1698-6180. ISSN (online): 1886-7995