The basal ganglia: a vertebrate solution to the selection problem?

Redgrave, Peter; Prescott, Tony J.; Gurney, Kevin

doi:10.1016/s0306-4522(98)00319-4

Cited by 1,012 publications

(816 citation statements)

References 95 publications

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“…The observation that the L-DOPA effect in the NAc was most pronounced during the final reversal errors that directly preceded behavioral switching reinforces the hypothesis that neural activity in the NAc is switchrather than outcome-related (Redgrave et al, 1999). This result concurs with our recent finding that the ventral striatum was selectively activated on switch, but not nonswitch trials (Cools et al, 2004).…”

Section: Discussionsupporting

confidence: 90%

“…Neurophysiological findings have shown that NAc neurons encode a combination of outcomepredictive information and behavioral switching and may indicate that NAc neurons encode behavioral switching only when they encode outcome-predicting information (Wilson and Bowman, 2005). Those findings may reconcile our observation that the NAc is active during final reversal errors, which signal not only a behavioral switch but also an upcoming rewarding outcome, with previous findings that (i) the NAc subserves switching (Cools, 1980;Redgrave et al, 1999) and (ii) other neurophysiological and neuroimaging data showing NAc-activity during reward-anticipation (Hollerman and Schultz, 1998;Knutson et al, 2001;Carelli, 2004;Knutson et al, 2005).…”

Section: Discussionsupporting

confidence: 83%

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L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease

Cools

Lewis

Clark

et al. 2006

Neuropsychopharmacol

262

207

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Evidence indicates that dopaminergic medication in Parkinson's disease may impair certain aspects of cognitive function, such as reversal learning. We used functional magnetic resonance imaging in patients with mild Parkinson's disease to investigate the neural site at which L-DOPA acts during reversal learning. Patients were scanned both ON and OFF their normal dopamine-enhancing L-DOPA medication during the performance of a probabilistic reversal learning task. We demonstrate that L-DOPA modulated reversal-related activity in the nucleus accumbens, but not in the dorsal striatum or the prefrontal cortex. These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 83%

L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease

Cools

Lewis

Clark

et al. 2006

Neuropsychopharmacol

262

207

View full text Add to dashboard Cite

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“…Lateral inhibition is a mechanism used to explain basal ganglia function (Groves, 1983;Wickens, 1993), because it might generate a type of neuronal competition (Wickens, 1993;Wickens and Oorshcot, 2000) to filter, choose, or switch motor programs (Redgrave et al, 1999;Bar-Gad and Bergman, 2001) and contribute to establish working memory traces (Beiser and Houk, 1998). The present experimental work shows that lateral inhibition may be modulated by dopamine.…”

Section: Physiological Relevancementioning

confidence: 62%

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

et al. 2003

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Dopamine is a critical modulator of striatal function; its absence produces Parkinson's disease. Most cellular actions of dopamine are still unknown. This work describes the presynaptic actions of dopaminergic receptor agonists on GABAergic transmission between neostriatal projection neurons. Axon collaterals interconnect projection neurons, the main axons of which project to other basal ganglia nuclei. Most if not all of these projecting axons pass through the globus pallidus. Thus, we lesioned the intrinsic neurons of the globus pallidus and stimulated neostriatal efferent axons antidromically with a bipolar electrode located in this nucleus. This maneuver revealed a bicuculline-sensitive synaptic current while recording in spiny cells. D 1 receptor agonists facilitated whereas D 2 receptor agonists depressed this synaptic current. In contrast, a bicuculline-sensitive synaptic current evoked by field stimulation inside the neostriatum was not consistently modulated, in agreement with previous studies. The data are discussed in light of the most recent experimental and modeling results. The conclusion was that inhibition of spiny cells by axon collaterals of other spiny cells is quantitatively important; however, to be functionally important, this inhibition might be conditioned to the synchronized firing of spiny neurons. Finally, dopamine exerts a potentially important role regulating the extent of lateral inhibition.

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“…This is because the behavior modules themselves provide information on their context and applicability, making arbitration between them a relatively simple computation [c.f. 37,51].…”

Section: Action Selectionmentioning

confidence: 99%

Agent-Based Composite Services in DAML-S: the Behavior-Oriented Design of an Intelligent Semantic Web

2003

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Abstract. Many researchers are working towards the goal of a semantic Weba Web that provides information in a way that is useful to artificial intelligences. A semantic Web would allow artificial agents to do the work of searching for and organizing services required by humans or organizations. DAML-S is a Web service ontology intended to facilitate the semantic Web by describing the properties and capabilities of Web-available services in an unambiguous, computerinterpretable form. In this paper, we propose that an important new perspective on the semantic Web can be obtained by regarding its content as behavioral intelligence. The services encoded in DAML-S can then be viewed as specifications either for extensions of the user agents attempting to exploit the services, or as independent, collaborative agents that can be 'awakened' to assist the user agents. We draw on our experience in agent development to elaborate the specification, particularly of the process ontology of DAML-S, in order to support this vision.

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The basal ganglia: a vertebrate solution to the selection problem?

Cited by 1,012 publications

References 95 publications

L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease

L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

Agent-Based Composite Services in DAML-S: the Behavior-Oriented Design of an Intelligent Semantic Web

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