The barrier function of the posterior capsule

Ozaki, Lieko

doi:10.1016/s0146-2776(84)80105-6

Cited by 21 publications

(9 citation statements)

References 6 publications

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“…Some sAPPα is also seen in the aqueous humor (Fig. 1E), but its levels are orders of magnitude lower, suggesting that the protein is unable to efficiently diffuse across the hyaloid membrane that separate the two humors [26]. …”

Section: Resultsmentioning

confidence: 99%

Differential Accumulation of Secreted AβPP Metabolites in Ocular Fluids1

Prakasam

Muthuswamy

Ablonczy

et al. 2010

JAD

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The Alzheimer amyloid-β (Aβ) accumulates in several types of retinal degeneration and in Alzheimer disease (AD), but its source has been unclear. We detected the neuronal 695 amino acid form of Aβ-precursor protein (AβPP) in the normal retina and AβPP751 in the retinal pigment epithelium (RPE) and anterior eye tissues. Similar to the brain, α- and β-secretases cleaved AβPP to soluble derivatives (sAPP) α or β and membrane-bound C-terminal fragments (CTF) α or β in the retina and RPE. Levels of sAPP were particularly high in the vitreous and low in aqueous humor revealing a molecular barrier for AβPP. In contrast, Aβ40 and Aβ42 levels were only 50% lower in the aqueous than the vitreous humor, indicating relatively barrier-free movement of Aβ. These studies demonstrated a relatively high yield of AβPP and Aβ in the ocular fluids, which may serve as a trackable marker for AD. In addition, failure of free clearance from the eye may trigger retina degeneration in a manner similar to Aβ-related neurodegeneration in AD.

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Section: Resultsmentioning

confidence: 99%

Differential Accumulation of Secreted AβPP Metabolites in Ocular Fluids1

Prakasam

Muthuswamy

Ablonczy

et al. 2010

JAD

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“…A comparison of the obtained results with the data on the lens capsule permeability coefficients obtained in [3][4][5][6][7] presents difficulties, because in these studies the measurements were carried out in the presence of hydrostatic pressure.…”

Section: Resultsmentioning

confidence: 99%

“…The volumetric flow was determined from the magnitude of the height of liquid in the capillary. The need for the fixation of the capsule between two reservoirs (similar constructions were also used in [6][7]), increases the sensitivity of such method to integrity and requires a sufficiently large size of the lens capsule samples. It should be also noted that permeability measurements were carried out under hydrostatic pressure.…”

Section: Introductionmentioning

confidence: 99%

In vitro spectroscopic investigation of human cataract lens capsule hydropermeability

Беликов

Zagorulko

Kochubey

et al. 2017

JBPE

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The dynamics of collimated transmission of optical radiation in the wavelength range 1100 2000 nm during the in vitro dehydration of human cataract lens capsules in air was studied for the first time. For capsules separated from human cataract lenses the average value of the hydropermeability coefficient at dehydration was 0.19±0.10 µm/s. The average characteristic time of cataract lens capsules dehydration was 77±10 s for the samples studied.

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“…The studies showed that removal of the central posterior capsule without disruption of the anterior hyaloid membrane with Nd:YAG laser capsulotomy or PPCC during cataract surgery does not disrupt the aqueous-vitreous barrier [13,14]. Mediator agents such as prostaglandins and angiogenetic factors can reach the posterior segment only via the disrupted lenszonule system [13,15]. An increased diffusion of inflammatory mediators into the vitreous and increased permeability of the blood-aqueous barrier may induce cystoid macular edema [3,16,17].…”

Section: Discussionmentioning

confidence: 99%

Which procedure has more effect on macular thickness: primary posterior continuous capsulorhexis (PPCC) combined with phacoemulsification or Nd:YAG laser capsulotomy?

et al. 2011

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To compare the effect of Nd:YAG laser capsulotomy and primary posterior continuous capsulorhexis (PPCC) combined with phacoemulsification on macular thickness using optical coherence tomography (OCT) in adults. This prospective comparative interventional study included 32 eyes of 30 patients who underwent Nd:YAG laser capsulotomy and 33 eyes of 33 patients who underwent cataract surgery with PPCC. Detailed ocular examinations, including macular thickness measurements by OCT, were performed in all patients preoperatively and postoperatively on the 1st day, 1st week, and 1st, 3rd and 6th months. No significant differences were found in macular thickness between the two groups in preoperative and postoperative follow-up. No cystoid changes were observed in OCT during the postoperative period in both groups. Nd:YAG laser capsulotomy and PPCC combined with cataract surgery are safe and effective procedures that are not associated with an increase in macular thickness.

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The barrier function of the posterior capsule

Cited by 21 publications

References 6 publications

Differential Accumulation of Secreted AβPP Metabolites in Ocular Fluids1

Differential Accumulation of Secreted AβPP Metabolites in Ocular Fluids1

In vitro spectroscopic investigation of human cataract lens capsule hydropermeability

Which procedure has more effect on macular thickness: primary posterior continuous capsulorhexis (PPCC) combined with phacoemulsification or Nd:YAG laser capsulotomy?

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