The Baroreflex in Hypertension

Fernandez, Genaro; Lee, Junsoo Alex; Liu, Lynn C.; Gassler, John P.

doi:10.1007/s11906-014-0531-z

Cited by 17 publications

(11 citation statements)

References 44 publications

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“…The classical role of baroreceptor afferents are related to the homeostatic control of blood pressure in health and disease [11][12][13] . Rats with surgically removed baroreceptor afferents [sino-aortic denervation (SAD)] displayed higher variability of the mean arterial pressure 11,14,15 , demonstrating the mandatory role for baroreceptor afferents integrity.…”

mentioning

confidence: 99%

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Amorim

Deus

Pereira

et al. 2020

Sci Rep

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Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles in health and disease. Sepsis is a life-threatening condition characterized by systemic inflammation (SI) and hemodynamic dysfunction. We hypothesized that baroreceptor denervation worsens lipopolysaccharide (LPS) induced-hemodynamic collapse and SI in conscious rats. We combined: (a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like non-lethal dose (b) analysis of the cardiovascular complexity, (c) evaluation of vascular function in mesenteric resistance vessels, and (d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that baroreceptor afferents are key to alleviate LPS-induced hemodynamic collapse, affecting the autonomic control of cardiovascular function, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse are not dependent of each other given that baroreceptor denervation worsened hypotension and reduced SI.

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mentioning

confidence: 99%

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Amorim

Deus

Pereira

et al. 2020

Sci Rep

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“…Baroreflex is a homeostatic mechanism responsible for short-term regulation of arterial blood pressure (ABP) [1]. As it constitutes one of the most important elements of neural control over the cardiovascular system, the assessment of baroreflex function is commonly used to evaluate the overall state of the autonomic nervous system (ANS) [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Baroreflex Sensitivity Using Time-Frequency Analysis during Postural Change and Hypercapnia

Kazimierska

Plaček

Uryga

et al. 2019

Computational and Mathematical Methods in Medicine

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Baroreflex is a mechanism of short-term neural control responsible for maintaining stable levels of arterial blood pressure (ABP) in an ABP-heart rate negative feedback loop. Its function is assessed by baroreflex sensitivity (BRS)—a parameter which quantifies the relationship between changes in ABP and corresponding changes in heart rate (HR). The effect of postural change as well as the effect of changes in blood O2 and CO2 have been the focus of multiple previous studies on BRS. However, little is known about the influence of the combination of these two factors on dynamic baroreflex response. Furthermore, classical methods used for BRS assessment are based on the assumption of stationarity that may lead to unreliable results in the case of mostly nonstationary cardiovascular signals. Therefore, we aimed to investigate BRS during repeated transitions between squatting and standing in normal end-tidal CO2 (EtCO2) conditions (normocapnia) and conditions of progressively increasing EtCO2 with a decreasing level of O2 (hypercapnia with hypoxia) using joint time and frequency domain (TF) approach to BRS estimation that overcomes the limitation of classical methods. Noninvasive continuous measurements of ABP and EtCO2 were conducted in a group of 40 healthy young volunteers. The time course of BRS was estimated from TF representations of pulse interval variability and systolic pressure variability, their coherence, and phase spectra. The relationship between time-variant BRS and indices of ABP and HR was analyzed during postural change in normocapnia and hypercapnia with hypoxia. In normocapnia, observed trends in all measures were in accordance with previous studies, supporting the validity of presented TF method. Similar but slightly attenuated response to postural change was observed in hypercapnia with hypoxia. Our results show the merits of the nonstationary methods as a tool to study the cardiovascular system during short-term hemodynamic changes.

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“…Some argued that the absence of a positive finding in Symplicity HTN-3 was mainly related to adding a sham procedure and blinding of patients, and others tried to provide other explanations [37]. Baroreflex activation therapy: Treatment based on baroreceptor activation is consistent with electrical stimulation located in the carotid sinus technique, resulting in reduced sympathetic outflow to the heart, vascular system and kidneys as well as an increase in parasympathetic tone [38]. Today, we have the results of two studies: the Device-Based Therapy in Hypertension trial (Debut-TH) [39] and the Rheos Pivotal Trial [40,41], which have shown promising results, although some complications directly related to the surgical procedure were observed.…”

Section: New Strategies For the Management Of Rhmentioning

confidence: 99%

Resistant Hypertension in Diabetes Mellitus

Armario¹

2015

JED

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The Baroreflex in Hypertension

Cited by 17 publications

References 44 publications

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Assessment of Baroreflex Sensitivity Using Time-Frequency Analysis during Postural Change and Hypercapnia

Resistant Hypertension in Diabetes Mellitus

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