The baroreflex afferent pathway plays a critical role in H2S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions

Liu, Ying; Feng, Yan; Liu, Li; Li, Xue; Li, Xinyu; Sun, Xun; Li, Kexin; Zha, Rongrong; Wang, Hongdan; Zhang, Mengdi; Fan, Xiongxiong; Wu, Di; Fan, Yao Shan; Zhang, Haocheng; Qiao, Guofu; Li, Bai‐Yan

doi:10.1038/s41401-020-00549-5

Cited by 16 publications

(9 citation statements)

References 53 publications

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“…A number of studies have shown that H 2 S modulates the brain cardiovascular centers, and these effects are exacerbated in spontaneously hypertensive animals (e.g., [ 158 , 159 , 160 , 161 ]). Several studies have shown an association between H 2 S and brain oxygenation.…”

Section: Evidence For H 2 S Mediated O 2 Sensing In Various Organ Systems and Tissuesmentioning

confidence: 99%

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Olson

2021

Antioxidants

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The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H2S) and polysulfides, collectively referred to as reactive sulfur species (RSS) as a physiologically relevant O2 sensing mechanism. This hypothesis is based on observations that H2S and RSS metabolism is inversely correlated with O2 tension, exogenous H2S elicits physiological responses identical to those produced by hypoxia, factors that affect H2S production or catabolism also affect tissue responses to hypoxia, and that RSS efficiently regulate downstream effectors of the hypoxic response in a manner consistent with a decrease in O2. H2S-mediated O2 sensing is then compared to the more generally accepted reactive oxygen species (ROS) mediated O2 sensing mechanism and a number of reasons are offered to resolve some of the confusion between the two.

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Section: Evidence For H 2 S Mediated O 2 Sensing In Various Organ Systems and Tissuesmentioning

confidence: 99%

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Olson

2021

Antioxidants

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“…Five types of potassium channels have been recognized in vascular cells, including voltage-dependent potassium channels (K V ), Ca 2+ -activated potassium channels (K Ca ), ATP-sensitive potassium channels (K ATP ), inward rectifier potassium channels (Kir), and tandem two-pore potassium channels (K 2P ) ( Dogan et al, 2019 ). Accumulating evidence has shown vascular potassium channels activation is involved in H 2 S-induced vasodilation ( Li et al, 2021 ; Marinko et al, 2021 ; Wen et al, 2021 ). However, the interaction of H 2 S with different vascular potassium channels and the underlying mechanisms have not been reviewed systematically.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels

2022

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Hydrogen sulfide (H2S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in H2S biogenesis has been reported in a variety of vascular diseases and H2S supplementation exerts effects of vasodilation. Accumulating evidence has shown vascular potassium channels activation is involved in H2S-induced vasodilation. This review aimed to summarize and discuss the role of H2S in the regulation of vascular tone, especially by interaction with different vascular potassium channels and the underlying mechanisms.

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“…K ATP channels are widely distributed in various organs, but the assembly of their subunits varies depending upon the tissue and they may confer different functional and pharmacological properties depending on which subunits are present ( Li et al, 2021 ; Stewart and Turner, 2021 ) ( Table 1 ). K ATP channels are comprised of four sulfonylurea receptors (SURx) and four K + inward rectifiers (Kir6.…”

Section: Introductionmentioning

confidence: 99%

Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases

et al. 2022

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ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate systole, involved in every heartbeat. Activation of the KATP channel repolarizes the membrane potential and decreases early afterdepolarization (EAD)-mediated arrhythmias. KATP channels in cardiomyocytes have less function under physiological conditions but they open during severe and prolonged anoxia due to a reduced ATP/ADP ratio, lessening cellular excitability and thus preventing action potential generation and cell contraction. Small active molecules activate and enhance the opening of the KATP channel, which induces the repolarization of the membrane and decreases the occurrence of malignant arrhythmia. Accumulated evidence indicates that mutation of KATP channels deteriorates the regulatory roles in mutation-related diseases. However, patients with mutations in KATP channels still have no efficient treatment. Hence, in this study, we describe the role of KATP channels and subunits in angiocardiopathy, summarize the mutations of the KATP channels and the functional regulation of small active molecules in KATP channels, elucidate the potential mechanisms of mutant KATP channels and provide insight into clinical therapeutic strategies.

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The baroreflex afferent pathway plays a critical role in H2S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions

Cited by 16 publications

References 53 publications

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels

Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases

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