The Balance between Bone Formation and Material Resorption in Unidirectional Porous β-Tricalcium Phosphate Implanted in a Rabbit Tibia

Noguchi

et al. 2020

Cureus

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Bone grafting is frequently performed in orthopedic surgeries. Artificial bone is a common grafting material. We have developed an absorbable material for bone regeneration with a unique structure: unidirectional porous β-tricalcium phosphate (Affinos ; Kuraray Co., Ltd., Tokyo, Japan). The most distinctive feature of this material is the ease with which blood can rapidly reach its depths by capillary action due to the unidirectional porous structure. It is also characterized by the presence of micropores, which are known to be beneficial for osteoconductivity both on the surface and inside the material. Favorable artificial bone absorption and regeneration with natural bone were observed in cases of clinical bone graft applications in the spine, extremities, benign bone tumor, trauma, and donor sites. Affinos is useful as a novel absorbable material for bone regeneration in various orthopedic surgeries.

Section: Discussionmentioning

confidence: 99%

Section: Figure 1: 3d-ct Image Of Affinosmentioning

confidence: 99%

Section: Figure 1: 3d-ct Image Of Affinosmentioning

confidence: 99%

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A Novel Unidirectional Porous β-tricalcium Phosphate Bone Substitute in Orthopedic Surgery: A Technical Note and Case Illustrations

Noguchi

et al. 2020

Cureus

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“…Affinos® (Kuraray Co., Tokyo, Japan), codeveloped with the Department of Orthopedics Surgery, Faculty of Medicine, University of Tsukuba, is a β -tricalcium phosphate ( β -TCP) artificial bone with a porosity of 57% (pore size: 25–300 μ m) and consists of a novel unidirectional porous structure [9]. Using both high-strength and porous hydroxyapatite (HA) and β -TCP would have caused issues with early loading in a pelvic fracture.…”

Section: Introductionmentioning

confidence: 99%

Surgical Repair of Acetabular Fracture Using Unidirectional Porous β-Tricalcium Phosphate

Iwasashi

Case Reports in Orthopedics

et al. 2019

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We report a case of an acetabular fracture treated using a unidirectional porous β-tricalcium phosphate artificial bone (Affinos®) to surgically repair bone defects. An 82-year-old man sustained an acetabular fracture on the left side and presented with shock on arrival along with impaired vital signs and systolic blood pressure. Upon stabilization, we performed an open reduction and internal fixation. However, there were significant bone defects, which were then fixed using Affinos® (both blocks and granules), an artificial β-tricalcium phosphate bone with a porosity of 57% (pore size: 25–300 μm), characterized by a novel unidirectional porous structure. By 18 months postoperatively, the patient was able to perform stair climbing and absorption and bone fusion around the artificial bone were observed. Affinos® has a frost-like structure, which endows it with good tissue-invasive properties because of the capillary effect. Moreover, it has excellent osteoconduction capability. In this case, both Affinos® blocks and granules showed good affinity, absorption, and bone substitution. Further prospective studies are required to confirm our findings.

“…Unidirectional porous β-tricalcium phosphate (UDPTCP; Affinos ® , Kuraray Co., Ltd., Tokyo, Japan) is a novel bone-graft substitute, with a porosity of 57%, containing pores with a diameter of 25–300 μm in one direction 1 ) . Animal experiments showed that the the artificial bone with unidirectional pores is characterized by good balance between its resorption and substitution with the autologous bone 2 , 3 ) . However, only a few clinical studies have evaluated its implantation characteristics in humans 4 , 5 , 6 , 7 ) .…”

Section: Introductionmentioning

confidence: 99%

A novel unidirectional porous β-tricalcium phosphate grafting for vertebral fracture in the elderly: preliminary case series

Tsukanishi²,

et al. 2019

J Rural Med

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Objective: To treat vertebral fractures with posterior wall injury in the elderly, vertebral bone grafting is generally performed through a posterior transpedicular approach, combined with pedicle screw fixation. An autologous bone is ideal to treat this disorder. However, harvesting autologous bones from the elderly with osteoporosis is limited by the amount and quality of available autologous bone. Thus, we developed a bone-grafting substitute. The newly developed unidirectional porous β-tricalcium phosphate, with a porosity of 57% (UDPTCP; Affinos ® , Kuraray Co., Ltd., Tokyo, Japan), is used in the bone-grafting procedure. This is the first report of UDPTCP used as an artificial bone graft in patients with an acute vertebral burst fracture. Materials and Methods: UDPTCP (mean: 4.2 g) was implanted through the pedicle, and posterior instrumentation was achieved with pedicle screws in five elderly patients. Resorption of UDPTCP and substitution with the autologous bone were evaluated on computed tomography (CT) and plain X-ray performed immediately and at 3, 6, and 12 months after the operation. Results: In case 1, the pedicle screws did not loosen, and UDPTCP was completely resorbed and replaced with the autologous bone at 3 postoperative months. In the other four cases, although the pedicle screws or the caudal part loosened because of osteoporosis, resorption of UDPTCP was observed at 3 postoperative months. At 6 postoperative months, progressive substitution with the autologous bone was confirmed, and at 12 postoperative months, formation of the good autologous bone was confirmed. Conclusion: This preliminary case series demonstrated that the newly developed UDPTCP shows good clinical potential as a bonegraft substitute for acute vertebral burst fractures in the elderly, including patients with osteoporosis.