The bacteriology of recurrent pyogenic cholangitis and associated diseases

Wong, Wing Sze; Teoh-Chan, C. H.; Huang, Chun‐Kai; Cheng, F. C. Y.; Ong, G. B.

doi:10.1017/s0022172400069643

Cited by 10 publications

(6 citation statements)

References 8 publications

(17 reference statements)

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“…The former precipitates with calcium ion to form calcium bilirubinate, which is the major component of brown pigment stones. Wong et al (18) have also found a strong association between the presence of bacteria and the occurrence of ductal stones in patients with recurrent pyogenic cholangitis. In the present study, bacterial cultures were positive in 80.6% of the stones that were analyzed and were positive in 91.7% of the bile specimens that were analyzed.…”

Section: Discussionmentioning

confidence: 92%

Bacteriological and electron microscopy examination of brown pigment stones

1989

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Bacteriological and morphological studies of 38 brown pigment common duct stones were performed. Stone cultures were positive for bacteria in 80.5% of those studied. Enterococci were the most common organisms that were isolated. Scanning electron microscopy showed the presence of bacteria in 84.2% of the stones. The bacteria were seen embedded within an amorphous matrix in alternating layers of flakelike crystals. Transmission electron microscopy showed the presence of gram-positive and gram-negative bacteria surrounded by a ruthenium red-stained exopolysaccharide material. Results of the bacteriological and knorphological studies confirmed the close relationship between the presence of bacteria and the development of brown pigment stones. Calcium bilirubinate stones are classified by their biochemical composition and morphological appearance into laminated brown stones and amorphous black stones (17). Brown pigment stones are an important cause of acute cholangitis in Oriental populations (5). Bacterial infection and the deconjugation of bile by bacterial P-glucuronidase * Corresponding author.

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Section: Discussionmentioning

confidence: 92%

Bacteriological and electron microscopy examination of brown pigment stones

1989

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“…The evidence for the association between liver fluke infection and bile duct malignancy included hospitalbased case-control studies and population-based studies that have correlated the incidence of bile duct cancer with the prevalence of liver fluke infection in various geographic areas [21] . In a hospital-based case series in Thailand, an unusually high incidence of cholangiocarcinoma was observed on autopsy and the biopsy materials taken from patients with O. viverrini infection.…”

Section: 3 a S S O C I A T I O N O F L I V E R F L U K E I N F E mentioning

confidence: 99%

Opisthorchis viverrini (liver fluke) as the lot of baleful parasite of tropical region-A replete synopsis

Gundamaraju¹,

Vemuri²

2014

Asian Pacific Journal of Tropical Disease

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“…Recurrent pyogenic cholangitis is the most common complication of liver fluke infection. Acute suppurative cholangitis may be caused by blockage of the extrahepatic bile ducts by masses of dead worms, ova and mucin, and this in turn results in ascending cholangitis ( 2 , 22 ). When the bile flow is hampered by the presence of flukes per se, their ova, the excreta of the flukes and mucin, then ascending bacterial infection usually follows.…”

Section: Benign Complications Of Liver Fluke Diseasementioning

confidence: 99%

“…When the bile flow is hampered by the presence of flukes per se, their ova, the excreta of the flukes and mucin, then ascending bacterial infection usually follows. The bacteria is Escherichia coli in the majority of patients ( 22 ). With repeated suppurative infection, the bile duct is filled with pus and the liver flukes die because of an unfavorable living environment, and the dead flukes are expelled through the ampulla of Vater ( 2 ).…”

Section: Benign Complications Of Liver Fluke Diseasementioning

confidence: 99%

Liver Flukes: the Malady Neglected

Lim

2011

Korean J Radiol

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Liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts. Infection occurs through ingestion of fluke-infested, fresh-water raw fish. The most well-known species that cause human infection are Clonorchis sinensis, Opisthorchis viverrini and Opisthorchis felineus. Adult flukes settle in the small intrahepatic bile ducts and then they live there for 20-30 years. The long-lived flukes cause long-lasting chronic inflammation of the bile ducts and this produces epithelial hyperplasia, periductal fibrosis and bile duct dilatation. The vast majority of patients are asymptomatic, but the patients with heavy infection suffer from lassitude and nonspecific abdominal complaints. The complications are stone formation, recurrent pyogenic cholangitis and cholangiocarcinoma. Approximately 35 million people are infected with liver flukes throughout the world and the exceptionally high incidence of cholangiocarcinoma in some endemic areas is closely related with a high prevalence of liver fluke infection. Considering the impact of this food-borne malady on public health and the severe possible clinical consequences, liver fluke infection should not be forgotten or neglected.

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The bacteriology of recurrent pyogenic cholangitis and associated diseases

Cited by 10 publications

References 8 publications

Bacteriological and electron microscopy examination of brown pigment stones

Bacteriological and electron microscopy examination of brown pigment stones

Opisthorchis viverrini (liver fluke) as the lot of baleful parasite of tropical region-A replete synopsis

Liver Flukes: the Malady Neglected

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