The Bacteriology of Intra-abdominal Infections

Swenson, Robert M.

doi:10.1001/archsurg.1974.01360030050013

Cited by 70 publications

(16 citation statements)

References 8 publications

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“…At the beginning of the operation, 10 ml peritoneal liquid were withdrawn from each patient and immediately subjected to bacterio logical examination. At the primary surgery stage, this showed the typical spectrum of bacteria as previously described by other authors [ 19,20]. E. coli was the leading germ, followed by Streptococcus faecalis and the large group of anaerobes.…”

Section: Germ Spectrum and Germ Elimination In Diffuse Peritonitissupporting

confidence: 74%

Spectrum of Bacteria in Infections in Abdominal Surgery

Kujath¹,

Eckmann²,

Schiedeck³

1996

Dig Surg

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Considering the initial antibiotic therapy of an affected organ, the surgeon must take into account the bacterial spectrum. In peritonitis, bacterial virulence, quantitative bacteriology (bacterial count) and bacterial synergism are enormously important. Early bacterial eradication can be achieved with a schedule of peritoneal lavage. Attention should also be paid to possible changes in the bacterial spectrum during the course of peritonitis treatment.

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Section: Germ Spectrum and Germ Elimination In Diffuse Peritonitissupporting

confidence: 74%

Spectrum of Bacteria in Infections in Abdominal Surgery

Kujath¹,

Eckmann²,

Schiedeck³

1996

Dig Surg

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“…The treatment of intraabdominal infection is challenging because of their polymicrobial nature [1][2][3] and accompanying death and complications. Treatment may be further complicated by bacteriologic resistance issues, such as the large number of ␤-lactamase-producing Enterobacteriaceae present in intraabdominal infections.…”

mentioning

confidence: 99%

Comparison of Intravenous/Oral Ciprofloxacin Plus Metronidazole Versus Piperacillin/Tazobactam in the Treatment of Complicated Intraabdominal Infections

et al. 2000

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“…coli and Bacteroides fragilis are two of the most commonly isolated pathogens from the cultures obtained during operations, leading to intra-abdominal infections [17,18]. In the study performed by Bercovici et al [6], it was shown that peritoneal fluid has bactericidal and bacteriostatic effects against gram-positive and gram-negative strains and fungi.…”

Section: Discussionmentioning

confidence: 99%

Influence of Omentectomy on Peritoneal Defense Mechanisms in an Experimental Model of Intra-Abdominal Infection

Ağca¹,

Paksoy²,

Polat

et al. 2003

Eur Surg Res

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Background/Aim: The omentum has an important role as part of peritoneal defense mechanisms. The aim of this study is to show the bactericidal activity of peritoneal fluid and the role of the omentum as a peritoneal defense mechanism in experimental animals with intra-abdominal infections. Methods: 40 male Spraque-Dawley rats weighing between 250 and 300 g were used in this study. The rats were randomly divided into four groups consisting of 10 animals. The operative procedures were done under sterile conditions. In group I sham laparotomy was done. In group II, the distal part of the cecum was ligated, and cecum perforation was performed. In group III, total omentectomy was performed after cecal ligation and perforation. In group IV only omentectomy was performed. Baseline and 2- and 4-hour peritoneal fluid samples were taken using a Pasteur pipette during laparotomy under anesthesia. Total peritoneal cells counts, bactericidal activity of peritoneal fluid, and types of phagocytic cells in the peritoneal fluid were assessed. Results: As compared with baseline values, the total peritoneal cell counts were increased at the 2nd and 4th h in all groups (p < 0.05). A significant increase was observed after 4 h as compared with 2 h in sham laparotomy, cecal ligation+perforation+omentectomy, and omentectomy groups (p < 0.05). A significant increase in the cell counts after 2 h was found in the other groups when compared to the sham laparotomy group (p = 0.0001). After 4 h, there was a significant difference between the groups, but especially prominent in the cecum ligation+perforation+omentectomy group (p = 0.0001). Proliferating colony counts of Escherichiacoli and Pseudomonas aeruginosa decreased after 2 h, and there was no proliferation in the subsequent cultures. It was observed that the macrophage counts significantly increased after 2 and 4 h as compared with baseline in intragroup assessments (p = 0.0001). In the intergroup assessment, an increase was observed in the macrophage counts at baseline and after 2 and 4 h, and this was significant in the cecal ligation+perforation+omentectomy group (p = 0.0001). In the omentectomy group, a significant decrease was observed in the macrophage counts between the 2nd and 4th h (p = 0.0001). Conclusion: Removal of the omentum in the presence of intra-abdominal infections causes the peripherally derived macrophages to take over the defensive role of macrophages of peritoneal origin as a compensatory mechanism, thus the peritoneal bactericidal activity against E. coli, the major pathogen in intra-abdominal infections, does not change after omentectomy.

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The Bacteriology of Intra-abdominal Infections

Cited by 70 publications

References 8 publications

Spectrum of Bacteria in Infections in Abdominal Surgery

Spectrum of Bacteria in Infections in Abdominal Surgery

Comparison of Intravenous/Oral Ciprofloxacin Plus Metronidazole Versus Piperacillin/Tazobactam in the Treatment of Complicated Intraabdominal Infections

Influence of Omentectomy on Peritoneal Defense Mechanisms in an Experimental Model of Intra-Abdominal Infection

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