The bacteriology of diabetic foot ulcers in Port Harcourt, Nigerian

Unachukwu, C N; Obunge, Orikomaba; Odia, O J

doi:10.4314/njm.v14i2.37176

Cited by 26 publications

(27 citation statements)

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“…The majority of these have shown that S. aureus remains the single most commonly isolated species, albeit accounting for a considerably lower proportion of all isolates (14-39%) [10][11][12][13]15,16] than in studies from Western countries (70-80%) [17][18][19]. The decreased proportion of isolates that are S. aureus is offset by greater numbers of Gram-negative bacteria and anaerobes [10][11][12][13][14][15][16][17]. There is no clear explanation for the apparent differences in the microbiological findings between developed and developing countries.…”

Section: Microbiology Of Dfimentioning

confidence: 99%

Novel antibiotics for the management of diabetic foot infections

Omar

El-Nahas

Gray

2008

International Journal of Antimicrobial Agents

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Section: Microbiology Of Dfimentioning

confidence: 99%

Novel antibiotics for the management of diabetic foot infections

Omar

El-Nahas

Gray

2008

International Journal of Antimicrobial Agents

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“…In Nigeria, there are over 10 million diabetic patients, half of which are unaware that they do have the disease with the highest prevalence > 30 years of age. Diabetic wounds/or foot ulcers and infections can lead to amputation of the foot or leg and one out 15 diabetic patients requires a limb amputation during their lifetime (Frier et al, 1999;Unachukwu et al, 2005). According to Motta et al (2003) and Raviskhar et al (2006) several enterobacteria and Gram-positive bacteria have been found to be associated with diabetic foot ulcers; therefore this should be a matter *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Widespread plasmid resistance genes among Proteus species in diabetic wounds of patients in the Ahmadu Bello university teaching hospital (ABUTH) Zaria

Yah¹,

S²,

Eghafona³

et al. 2007

Afr. J. Biotechnol.

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Plasmids have been known to play a major role in the dissemination of antibiotics resistance genes in a microbial population. In this background, 148 Proteus species comprising of 97 Proteus mirabilis and 51 Proteus vulgaris were isolated from diabetic wounds. Seventy-six strains had varied multi-drug resistance (MDR) pattern encoded on transferable plasmid gene with a very high frequency (2 x10 -4 to 4 x 10 -2 per donor cell) by conjugation. 34% of the strains lost the antibiotic resistance plasmids marker after sodium dodecyl sulfate (SDS) mediated curing. The rest of the plasmid markers were non transferable. The results indicated that plasmids carry varied dissemination of antibiotics resistance markers to distant recipient cells, indicating clonal transfer among bacterial strains.

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“…One important challenge for physicians involved in the care of diabetics is the choice of appropriate antibacterial agents. The challenge is made more complex by the so-called new emerging (infectious) diseases and resistance of bacterial pathogens to traditional antibacterial drug treatment [8,9]. In addition, just like all other drugs, antibacterials have side-effects and can have drug-drug interactions with other concomitantly used drugs, including other antibacterials.…”

Section: Introductionmentioning

confidence: 99%

A retrospective Evaluation of Antibacterials Used in the Management of Diabetics in a Tertiary Hospital in South-western Nigeria

Ayeni¹,

Akinkunmi²,

Ikem³

et al. 2015

JPP

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Abstract:Objective: Co-medication with antibacterials is often necessary in the management of diabetic patients. There is a constant need to evaluate the use of these antibacterials to improve therapeutic outcomes and to avoid practices that could possibly increase the emergence of antimicrobial resistance. The aim of this study was to evaluate the utilization of antibacterials in the diabetic clinic of a Nigerian tertiary hospital. Methods: A retrospective evaluation and analysis of patients' case notes written by physicians in the diabetic clinic over a three-year period (January, 2008-December, 2010) was conducted. The case notes were the individual medical records for 150 different hospitalized diabetic patients with infection as co-indication. Data was collected using a WHO instrument for studies of rational drug use. Results: Descriptive statistics such as mean, frequency, percentages and standard deviation were used to analyze categorical data obtained from the demographic variables. Fisher exact test and chi square test were employed to determine whether there were statistically significant differences or associations between mean values of antibacterial prescription pattern and attendant dosage errors. (P =/< 0.05 was accepted as significant). Comparing the mean number of antibacterial drugs in each prescription yearly yielded a mean of 1.32 in 2008, 1.37 in 2009 and 1.67 in 2010, indicating that there was no statistically significant difference. Antibacterials were used to manage complications often seen in the diabetic patient, including; diabetic foot gangrene, injection abscess, septiceamia, diabetic foot ulcer, vaginal yeast infection, amongst others. Conclusions: The majority of prescriptions met the criteria for compliance with the hospital's drug use protocol. The few instances of non-compliance with the hospital's antibiotic drug use protocol may indicate the need for continuing education, especially for the less experienced prescribers.

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The bacteriology of diabetic foot ulcers in Port Harcourt, Nigerian

Cited by 26 publications

References 0 publications

Novel antibiotics for the management of diabetic foot infections

Novel antibiotics for the management of diabetic foot infections

Widespread plasmid resistance genes among Proteus species in diabetic wounds of patients in the Ahmadu Bello university teaching hospital (ABUTH) Zaria

A retrospective Evaluation of Antibacterials Used in the Management of Diabetics in a Tertiary Hospital in South-western Nigeria

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