The Bacteriology of Acne

Shehadeh, Najib H.

doi:10.1001/archderm.1963.01590240153025

Cited by 61 publications

(22 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The resulting skin condition with sebum enrichment is prone to the anaerobic growth of Propionibacterium acnes, which is the main causative microorganism in acne. In addition, Staphylococcus epidermidis and Pitryosporum ovale are present in acne lesions [6]. Proliferation of these microorganisms, mainly P. acnes, leads to inflammatory lesions and severe acne.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

SynopsisAcne vulgaris suppresses an individual's self-confidence by causing distress with regard to physical appearance, which affects a significant number of individuals during puberty and is delineated by adolescence. Several treatments have been introduced to decrease the aesthetic and psychological problems caused by acne. The topical application of therapeutic agents has been found to be more feasible than hormonal treatment and laser therapy. The ingredients in topical acne treatments, particularly herbs and naturally derived compounds, have received considerable interest as they have fewer adverse effects than synthetic agents. Ré suméL'acné vulgaire touche à l'assurance d'un individu en causant une détresse face à son apparence physique. Elle affecte un nombre important d'individus pendant la puberté et est associée à l'adolescence. Plusieurs traitements ont été proposés pour diminuer les problèmes esthétiques et psychologiques causés par l'acné. L'application topique d'agents thérapeutiques a été estimée plus aisée qu'un traitement hormonal et une thérapie laser. Les ingrédients des traitements topiques de l'acné, particulièrement les plantes et les composés naturels dérivés ont suscité un intérêt considérable par leurs moindres effets indésirables que les ingrédients synthé-tiques.

show abstract

Section: Introductionmentioning

confidence: 99%

Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

show abstract

“…Propionibacterium acnes can regularly be isolated from acne vulgaris lesions (14) and frequently from actinomycotic (9) or nonspecific anaerobic infectious processes (13). There seems to be strong evidence that P. acnes is an important etiological factor in acne vulgaris because of the release of large amounts of free fatty acids from sebum triglycerides (16).…”

mentioning

confidence: 99%

Antimicrobial Susceptibility of Propionibacterium acnes and Related Microbial Species

Hoeffler

Pulverer

1976

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The minimal inhibitory concentrations of 32 antimicrobial agents were established for 73 strains of Propionibacterium acnes and four related species (P. granulosum, P. avidum, Corynebacterium minutissimum, and C. parvum). Most strains showed good susceptibility to those agents usually considered active against gram-positive organisms. With the exception of C. minutissimum, the strains tested revealed more or less identical susceptibility ranges. The lowest minimal inhibitory concentrations were observed with benzylpenicillin, ampicillin, cephalothin, rifampin, erythromycin, clindamycin, and minocycline. C. minutissimum was more susceptible to gentamicin, sisomicin, tobramycin, and fusidic acid but more resistant to most other drugs than were the other species examined.

show abstract

“…It can be concluded that erythro mycin probably acts by suppressing the bacterial population in the sebaceous glands. Three groups of microorganisms, C. acnes, S. epidermidis and Pityrosporum are generally found in the comedones [II, 23,32], We are therefore now studying both in vitro and in vivo the effect of erythromycin stearate on bacterial flora, subcultured under standardised conditions on special media. The results of the running quantitative cultures before and after erythromycin therapy (250 mg daily for 1-3 weeks) show that erythromycin only slightly reduces the C. acnes counts.…”

Section: Discussionmentioning

confidence: 99%

Erythromycin Stearate in Acne vulgaris: Its Effect on the Skin Surface Lipids and on the Activity of Purified Pancreatic Lipase

Hellgren¹,

Vincent²

1978

Dermatology

View full text Add to dashboard Cite

To study the mechanism of action of erythromycin stearate in acne vulgaris, the composition of the skin surface lipids was analyzed before, during and after treatment (500 mg daily for 1 week, 250 mg daily for 2 months) in 17 patients. Quantitative thin-layer chromatography showed that the fatty acid fraction in the skin surface lipids decreased significantly during the treatment period. The clinical effect was good in 14 of 17 patients. Further investigations were performed on the effect of erythromycin stearate on purified pancreatic lipase. The enzyme activity was not inhibited by exposure to the drug.

show abstract

The Bacteriology of Acne

Cited by 61 publications

References 2 publications

Therapeutic agents and herbs in topical application for acne treatment

Therapeutic agents and herbs in topical application for acne treatment

Antimicrobial Susceptibility of Propionibacterium acnes and Related Microbial Species

Erythromycin Stearate in Acne vulgaris: Its Effect on the Skin Surface Lipids and on the Activity of Purified Pancreatic Lipase

Contact Info

Product

Resources

About