The B7 Family Member B7-H6: a New Bane of Tumor

Chen, Ying; Mo, Jun Qin; Jia, Xi; He, Yao

doi:10.1007/s12253-017-0357-5

Cited by 36 publications

(34 citation statements)

References 43 publications

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“…Decreased expression of CD80 was found in gastric cancer, which is consistent with our experimental results, and gene therapy with CD80 inhibits metastasis [24,27,29]. B7-H6 has been demonstrated to be overexpressed in gastric cancer [30]. And B7-DC was reported to be highly expressed in EBV-associated gastric cancer [31].…”

Section: Discussionsupporting

confidence: 85%

Comprehensive understanding of B7 family in gastric cancer: expression profile, association with clinicopathological parameters and downstream targets

Li¹,

Xiang²,

Shen³

et al. 2020

Int. J. Biol. Sci.

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Objectives: B7 family members were identified as co-stimulators or co-inhibitors of the immune response and played important roles in cancer immunotherapy; however, their dysregulation in gastric cancer is still unclear. Methods: Data were obtained from TCGA and GTEX database. B7 mutations, association with DNA methylation and affected proteins were analyzed in cBioportal. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and Gene Ontology (GO) project was studied by DAVID to find the downstream signaling pathway and important metabolic process, respectively. Protein-protein interaction network was analyzed in STRING and Cytoscape. A total of 160 paired specimens in tissue microarray from patients with gastric cancer were used to detect the expression levels of seven B7 family members via immunohistochemical analysis. Results: Bioinformatics studies revealed dysregulation of B7 members in gastric cancer. Gene and protein alteration were found in B7 family members. Furthermore, DNA methylation and gene alteration may be both involved in B7 member dysregulation in gastric cancer. Importantly, the high expression of B7-H6 is associated with good overall patient survival. B7 family members primarily affect the EGFR tyrosine kinase inhibitor resistance signaling pathway in gastric cancer and TP53 may be an important target of the family. The low expression of B7-1 and high expression of B7-H3 and B7-H7 were validated by IHC staining. Conclusions: Our results provide insight into B7 family member expression in gastric cancer and stress their importance in stomach tumorigenesis, which may be beneficial for designing future cancer treatments.

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Section: Discussionsupporting

confidence: 85%

Comprehensive understanding of B7 family in gastric cancer: expression profile, association with clinicopathological parameters and downstream targets

Li¹,

Xiang²,

Shen³

et al. 2020

Int. J. Biol. Sci.

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“…B7-H6 is a ligand for NKp30, a member of the CD28 family that functions as an NK-activating receptor. Localized on human chromosome 11p15.1, B7-H6 is undetectable at both the protein and transcriptional levels in normal tissues and unstimulated healthy peripheral blood mononuclear cells and is regarded as a new weakness of tumors (96). Human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2, also known as B7-H7) uniquely maps to human chromosome 3q13.13 and has 10% homology with the B7 family.…”

Section: Other Members Of the B7 Family: Btnl2 B7-h6 And B7-h7mentioning

confidence: 99%

The Role of B7 Family Molecules in Maternal–Fetal Immunity

2020

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Pregnancy is a complex but well-arranged process, and a healthy fetus requires immune privilege and surveillance in the presence of paternally derived antigens. Maternal and fetal cells interact at the maternal-fetal interface. The upregulation and downregulation of maternal immunity executed by the leukocyte population predominantly depend on the activity of decidual natural killer cells and trophoblasts and are further modulated by a series of duplex signals. The B7 family, which consists of B7-1, B7-2, B7-H1, B7-DC, B7-H2, B7-H3, B7-H4, B7-H5, BTNL2, B7-H6, and B7-H7, is one of the most characterized and widely distributed signaling molecule superfamilies and conducts both stimulatory and inhibitory signals through separate interactions. In particular, the roles of B7-1, B7-2, B7-H1, and their corresponding receptors in the progression of normal pregnancy and some pregnancy complications have been extensively studied. Together with the TCR-MHC complex, B7 and its receptors play a critical role in cell proliferation and cytokine secretion. Depending on this ligand-receptor crosstalk, the balance between the tolerance and rejection of the fetus is perfectly maintained. This review aims to provide an overview of the current knowledge of the B7 family and its functions in regulating maternal-fetal immunity through individual interactions.

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“…It was a core cell of the natural immune system and can eliminate tumour cells. NK-cells activation was regulated by some activation receptors or inhibition receptors on the cell surface (10). The major activating receptors included NKG2D and the natural cytotoxicity receptors (NCRs) such as NKp46, NKp30, and NKp44 (20).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, Lijie Chen et al demonstrated that B7-H4 expression level was associated with ESCC progression and survival, by reducing tumor immunosurveillance (9). B7-H6 is a newly identified ligand in the B7 family (10,11). It is a type I transmembrane protein that shows considerable homology with the B7-H1 and B7-H3 proteins (12).…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of B7-H6 in esophageal squamous cell carcinoma

Zhou

Dong

Guo

et al. 2019

Preprint

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Background : B7-h6, a member of the B7 family molecules, participates in the clearance of tumor cells by binding to NKp30 on NK cells. The expression of B7-H6 in esophageal squamous cell carcinoma (ESCC) and the clinical significance is unknown. The goal of this study was to determine the expression of B7-H6 in ESCC and further explore its clinical significance. Patients and methods: We retrospectively collected clinical data from 145 patients diagnosed with ESCC between January 2007 and December 2008. These patients had all previously undergone surgical treatment for esophageal cancer, were clearly diagnosed, and had not received chemotherapy or radiotherapy. In addition, pathological tissue samples from the 145 patients were collected to detect the expression of B7-H6 by immunohistochemistry. The chi-square (χ2) test was used to analyse the relationships between B7-H6 and clinicopathological characteristics. The prognosis of the patients was analysed by Cox proportional hazards regression analysis and Kaplan-Meier analysis. Results: 133/145 (91.72%) of the ESCC tissue samples exhibited B7-H6 expression. The expression level of B7-H6 was correlated with T stage (P=0.036) and lymphatic metastasis status ( P =0.044). According to the results of the ROC curve analysis, H-score =90 was selected as the cut-off value. The 145 patients were divided into two groups, the high B7-H6 expression (H-score＞90) group and the low B7-H6 expression (H-score≤90) group. Cox proportional hazards regression analysis indicated that tumour size ( P =0.021), B7-H6 expression ( P =0.025) and lymphatic metastasis status ( P =0.049) were independent prognostic factors for ESCC. Kaplan-Meier analysis with the log-rank test demonstrated that the patients with high B7-H6 expression ( P = 0.003), lymphatic metastasis ( P <0.001) or a tumour size ≥ 3.0 cm ( P = 0.001) had significantly worse survival than those with low B7-H6 expression, no lymphatic metastasis or a tumour size < 3.0 cm respectively. Conclusion: Our findings suggest that B7-H6 is widely expressed in ESCC samples. And B7-H6 may represent a predictor of poor prognosis for ESCC. Keywords: B7-H6, Esophageal squamous cell carcinoma, Immunohistochemistry, prognosis.

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The B7 Family Member B7-H6: a New Bane of Tumor

Cited by 36 publications

References 43 publications

Comprehensive understanding of B7 family in gastric cancer: expression profile, association with clinicopathological parameters and downstream targets

Comprehensive understanding of B7 family in gastric cancer: expression profile, association with clinicopathological parameters and downstream targets

The Role of B7 Family Molecules in Maternal–Fetal Immunity

The prognostic value of B7-H6 in esophageal squamous cell carcinoma

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