New constraints on the tectonic evolution of the Neo-Tethys Ocean indicate that at ∼90-70 Ma and at ∼50-40 Ma, vast quantities of mafic and ultramafic rocks were emplaced at low latitude onto continental crust within the tropical humid belt. These emplacement events correspond temporally with, and are potential agents for, the global climatic cooling events that terminated the Cretaceous Thermal Maximum and the Early Eocene Climatic Optimum. We model the temporal effects of CO 2 drawdown from the atmosphere due to chemical weathering of these obducted ophiolites, and of CO 2 addition to the atmosphere from arc volcanism in the Neo-Tethys, between 100 and 40 Ma. Modeled variations in net CO 2 -drawdown rates are in excellent agreement with contemporaneous variation of ocean bottom water temperatures over this time interval, indicating that ophiolite emplacement may have played a major role in changing global climate. We demonstrate that both the lithology of the obducted rocks (mafic/ultramafic) and a tropical humid climate with high precipitation rate are needed to produce significant consumption of CO 2 . Based on these results, we suggest that the low-latitude closure of ocean basins along east-west trending plate boundaries may also have initiated other long-term global cooling events, such as Middle to Late Ordovician cooling and glaciation associated with the closure of the Iapetus Ocean.climate change | climate-tectonic connection | arc-continent collision O ver geologic time, atmospheric pCO 2 is regulated by a balance between sources and sinks (1-5), including the products of volcanism (6), metamorphism (7, 8), and silicate weathering (4), which are fundamentally the results of plate tectonic processes (9-11). However, attempts to relate particular episodes of Cretaceous to recent climate change to specific tectonic events remain controversial (1,9,(12)(13)(14)(15).Studies of present-day chemical weathering document an important control of lithology and paleogeography on weathering rates and associated CO 2 drawdown (16,17). Highly active regions of intense chemical weathering account for >50% of the consumed CO 2 per year, yet the proportion of this land area is <10% (18, 19). In these areas, high CO 2 consumption rates are the consequence of elevated physical and chemical weathering rates, which result from a combination of significant topographic relief, high rates of precipitation (20), elevated surface temperatures, and exposure of large volumes of highly weatherable mafic and ultramafic) rocks (16,17,21). Such conditions are characteristic of tectonically active (or recently active) regions located at low latitude, within the Intertropical Convergence Zone (ITCZ) and adjacent regions of humid tropical climate and high precipitation (6,9,16). Based on these observations, we propose that the obduction of mafic and ultramafic rocks at low latitude that resulted from arc-continent collision during the closure of the Neo-Tethys Ocean exerted important controls on Late Cretaceous to Eocene (100-40 Ma) g...