“…Dysregulation of Axl or its ligand Gas6 is implicated in the pathogenesis of a variety of human cancers. Overexpression of Axl has been reported in a wide array of human cancers (Craven et al, 1995;Ito et al, 1999;Berclaz et al, 2001;Sun et al, 2004;Shieh et al, 2005) and is associated with invasiveness and metastasis in lung (Shieh et al, 2005), prostate (Sainaghi et al, 2005), breast (Meric et al, 2002;Zhang et al, 2008), gastric (Wu et al, 2002) and pancreatic (Koorstra et al, 2009) cancers, renal cell carcinoma (Chung et al, 2003) as well as glioblastoma (Hutterer et al, 2008). Recently, by profiling of phosphotyrosine signaling, activated Axl protein was detected in about 5% primary tumors of non-small-cell lung cancer (NSCLC) (Rikova et al, 2007).…”