The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Generation 2 questionnaire data capture May-July 2020

Abstract

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 from the Bristol area (UK). ALSPAC has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. From 2012, ALSPAC has identified G1 participants who were pregnant (or their partner was) or had become parents, and enrolled them, their partners, and children in the ALSPAC-Generation 2 (ALSPAC-G2) study, providing a unique multi-generational cohort. At present, approximately 1,100 G2 children (excluding those in utero) from 810 G1 participants have been enrolled. In response to the COVID-19 pandemic, ALSPAC rapidly deployed two online questionnaires; one during the initial lockdown phase in 2020 (9th April-15th May), and another when national lockdown restrictions were eased (26th May-5th July). As part of this second questionnaire, G1 parents completed a questionnaire about each of their G2 children. This covered: parental reports of children’s feelings and behaviour since lockdown, school attendance, contact patterns, and health. A total of 289 G1 participants completed this questionnaire on behalf of 411 G2 children. This COVID-19 G2 questionnaire data can be combined with pre-pandemic ALSPAC-G2 data, plus ALSPAC-G1 and -G0 data, to understand how children’s health and behaviour has been affected by the pandemic and its management. Data from this questionnaire will be complemented with linkage to health records and results of biological testing as they become available. Prospective studies are necessary to understand the impact of this pandemic on children’s health and development, yet few relevant studies exist; this resource will aid these efforts. Data has been released as: 1) a freely-available dataset containing participant responses with key sociodemographic variables; and 2) an ALSPAC-held dataset which can be combined with existing ALSPAC data, enabling bespoke research across all areas supported by the study.

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

“…To validate our findings for selected candidate metabolites associated with AAM and ANM, we tested the association of directly measured levels of these metabolites with the two traits in ALSPAC. The ALSPAC is a population-based birth cohort study, which enrolled 14,541 pregnant women resident in Avon, UK, with expected delivery dates between 1 April 1991 and 31 December 1992 [ 44 , 45 ]. Of the initial pregnancies, there was a total of 13,988 children who were alive at 1 year of age.…”

The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021

“…So far, ALSPAC has conducted four COVID-19 questionnaires using G0 and G1 data: the first between 9 th April and 15 th May 2020 8 , the second between 26 th May and 5 th July 2020 9 , the third -with a first home-based antibody test -between 3 rd and 20 th October 2020 10 , and the fourth between 17 th November 2020 and 19 th March 2021 11 . As part of the second questionnaire, parents of G2 children also completed a questionnaire for each of their children 12 .…”

The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture November 2020 – March 2021

“…So far, ALSPAC has conducted three COVID-19 questionnaires using G0 and G1 data: the first between 9 th April to 15 th May 2020 7 , the second between 26 th May to 5 th July 2020 8 ; and the third, with an antibody test, between 3 rd and 20 th October 2020 9 . As part of the second questionnaire, parents of G2 children also completed a questionnaire for each of their children 10 .…”