The availability of references and the sponsorship of original research cited in pharmaceutical advertisements

Cooper, Richelle J.

doi:10.1503/cmaj.1031940

Cited by 61 publications

(89 citation statements)

References 21 publications

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“…Similar findings were also consistent with findings of other studies. 2,3,18,19 Printed promotional material is an important source of information. Most health professionals are dependent on commercial sources of drug information from medical representatives, drug advertisement brochures etc., and it has great impact on prescribing behaviour.…”

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confidence: 99%

Critical appraisal of Drug Promotional Literatures (DPLs) as per World Health Organization (WHO) guidelines

Vyas¹,

Bhave²

2018

Int J Basic Clin Pharmacol

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Background: The study was aimed to critically analyse Drug Promotional Literatures (DPLs) using WHO guidelines. This would help to create awareness about DPLs amongst healthcare providers thus encouraging the improvement of healthcare system.Methods: This cross sectional observational study was carried out at Department of Pharmacology, Medical College Baroda. DPLs were collected & critically analysed for consistency, accuracy, validity of the provided information as per WHO guidelines.Results: Out of total 616 DPLs collected, 371 satisfied the inclusion criteria. None of the DPL was fulfilling all criteria according to WHO guidelines. Most of DPLs were having information regarding; generic name / INN (98.39%), brand name (100%), amount of active ingredient per dosage (94.07%), approved therapeutic uses (84.91%), dosage form (91.37%) and name & address of manufacturers (91.91%). Of all the DPLs, information provided for safety parameters like; name of active ingredient known to cause problem (11.59%), dosage regimen (32.88%), side effects & drug reaction (14.56%), major drug interactions (14.02%) and precautions, contraindications and warning (14.29%) seemed to be grossly neglected. Total of 431 claims were evaluated, of which the most common type of claim was efficacy (55.45%). Relevant references to claims were present in (48.74%) DPLs. Total 203 references were evaluated from 371 DPLs, of which maximum reference were from journal article (74.38%).Conclusions: From this study, it was concluded that pharmaceutical companies didn’t follow the WHO guidelines for ethical drug promotion, thus failing to fulfil the rational promotion of drugs. Given the present findings physicians should be cautious about drawing conclusions regarding medicine based on DPLs provided by pharmaceutical companies.

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Section: %mentioning

confidence: 99%

Critical appraisal of Drug Promotional Literatures (DPLs) as per World Health Organization (WHO) guidelines

Vyas¹,

Bhave²

2018

Int J Basic Clin Pharmacol

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“…For clinical claims, advertisements are often deficient in the use of supporting information, 9-12 the representativeness of the information, 5,7,11,[13][14][15][16] the quality of the information, 7,11,[15][16][17][18][19] the sponsorship of the information, 9 and the availability of the information. 7,9,11,16 For example, Cooper and Schriger (2005) found that 28.8% of medical claims in 438 pharmaceutical advertisements in 10 U.S. medical journals in 1999 did not have references to support the claims, and 18.7% (135/721) of the references that were used cited "data on file;" only 20.5% (18/88) of requests for "data on file" was found to be actually available.…”

Section: -5mentioning

confidence: 99%

Drug Company Advertising in Medical Journals About the Health-Economic Advantages of Their Products for 2000-2006 Versus 1990-1999

Palmer

Timm²,

Neumann³

2008

JMCP

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“…9 An analysis of 438 unique advertisements appearing in the 1999 issues of 10 American medical journals (nine of which were peer-reviewed) showed that 28% of the 721 references cited were listed as "data on file". 12,13 Similar problems have also been detected in other marketing media used to bring medicine-related information to the attention of prescribers. An analysis of the advertisements included in Australian prescribing software showed that compliance with the requirements for included information was far from universal.…”

Section: Discussionmentioning

confidence: 70%

Quality of pharmaceutical print advertising in South Africa—assessment of reproductive health advertisements 2001–2005

Shaw¹,

Gray

2009

South African Family Practice

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Background: Pharmaceutical advertising, in a variety of forms, has been shown to influence prescribing behaviour. Regulatory systems have therefore been concerned with the quality of advertising and compliance with either imposed or self-regulatory codes of practice. Although the South African Medicines Act provides for an enforceable code of practice, the draft version published in 2004 has yet to be put into effect. This study aimed to assess the quality of pharmaceutical advertisements for reproductive health products, published in South African medical publications over the period 2001 to 2005. Compliance with the draft code of practice was considered, as well as the usefulness of the code itself.Methods: Half-page and larger print advertisements for reproductive health medicines were sought from two South African peer-reviewed and four non-peer-reviewed medical publications. Advertisements published in three consecutive months in 2001 to 2005 were selected. This period represented the period prior to legislation being developed and the period during which the code of practice was developed and published for comment. Details from each advertisement were captured independently by two reviewers using a pre-determined, pre-tested 60-question questionnaire. Differences were resolved by consensus. The questionnaire was pre-tested and adapted before being applied. Questions sought to identify characteristics of the advertisement that were indicative of quality relating to claims and evidence used in support of the claims, as well as adherence to the draft code of practice. The number of claims made in each advertisement was identified, and for each claim the evidence provided in the form of references was assessed.Results: A total of 136 reproductive health product advertisements were retrieved from 105 medical publications. Only 63 advertisements were unique. On average each medical publication selected contained 1.3 reproductive health product advertisements. All but three advertisements were for registered orthodox medicines. A total of 191 'claims' could be discerned in advertisements placed in medical publications (average 3.0 'claims' per advertisement). Only 7/103 (6.8%) references cited in unique advertisements in medical publications could be retrieved in abstract form from Medline, and only 1/7 (14.3%) of these references could be retrieved in free full-text format. In total, 14/103 (13.6%) of the references cited in advertisements placed in medical publications were listed as "data on file". Compliance with the relevant general regulation was easier to judge, and seen more often, than was the case in respect of the more subjective elements included in the draft code of practice.Conclusions: The quality of advertisements for reproductive health products placed in medical publications appears to fall short of at least some of the requirements of both existing and draft regulatory instruments. This may potentially have deleterious consequences for both prescriber and consumer behaviour. The draft c...

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The availability of references and the sponsorship of original research cited in pharmaceutical advertisements

Cited by 61 publications

References 21 publications

Critical appraisal of Drug Promotional Literatures (DPLs) as per World Health Organization (WHO) guidelines

Critical appraisal of Drug Promotional Literatures (DPLs) as per World Health Organization (WHO) guidelines

Drug Company Advertising in Medical Journals About the Health-Economic Advantages of Their Products for 2000-2006 Versus 1990-1999

Quality of pharmaceutical print advertising in South Africa—assessment of reproductive health advertisements 2001–2005

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