The Availability of Echinococcus IgG ELISA for Diagnosing Pulmonary Hydatid Cysts

Aydın, Yener; Altuntas, Bayram; Kaya, Abdülkadir; Ulas, Ali Bilal; Uyanık, Muhammet Hamidullah; Eroğlu, Atilla

doi:10.5152/eurasianjmed.2018.160104

Cited by 11 publications

(13 citation statements)

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“…Otherwise, the clinician is confronted by a dilemma and the diagnosis remains challenging. Previous studies reported a positive serology in 57% of the patients with pulmonary HC (13). In our study, it was positive in 87.2% of the cases.…”

Section: Discussionsupporting

confidence: 65%

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Hydatid disease among adults and children: it is time to worry!

et al. 2019

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Background: Hydatid disease is a public health issue as it continues to produce substantial morbidity and mortality. The most common affected organ among adults is the liver and among children, is the lungs. Its treatment includes medical therapy, surgical intervention or percutaneous drainage. We aimed to identify the clinical, therapeutic and evolutionary features of hydatid cyst among adults and children. Method: We conducted a retrospective study including all patients hospitalized in Pediatric and Infectious disease department for hydatid cyst between 1990 and 2018. Results: Overall, we enrolled 71 patients, among whom 37 (52.1%) were male. The median age was 28 years [3-87years]. The revealing symptoms were fever in 19 cases (26.7%) and cough in 18 cases (25.3%). Hepatic hydatid cyst was the main site, noted in 45 cases (63.4%), among which adults represented 37 cases (52.1%). Hydatid serology was positive in 87.2% of the cases. The treatment was surgical and followed by medical treatment based on albendazole in 43 cases (60.5%). The median duration of treatment was 4 months [1-60 months]. The most common adverse reactions of albendazole were elevated hepatic enzymes and reversible alopecia noted in 7 (12.7%) and 5 cases (9%). The disease evolution was marked by the occurrence of recovery in 53 cases (74.7%). Conclusion: Our study highlighted the burden of hydatid disease in our region, which remains endemic. It might be misdiagnosed since not only clinical symptoms are misleading, but also, imaging results can be concealing.

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Section: Discussionsupporting

confidence: 65%

“…Also, the cyst size, location and vitality of larval cysts interfered in the results (12). Actually, pulmonary, cerebral and splenic HC cause less antibody response compared to hepatic and bone HC (13).…”

Section: Discussionmentioning

confidence: 99%

Hydatid disease among adults and children: it is time to worry!

et al. 2019

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“…The last tested diagnostic kit – NovaLisa TM Echinococcus IgG (NovaTec Immunodiagnostica, Germany) shows the detection of the IgG antibodies to Echinococcus spp. Despite the fact that this commercial test is commonly used in laboratories ( Aydin et al, 2018 ) , studies on its sensitivity and specificity are very rare. The producer claims a high rate of diagnostic sensitivity (97.2 %) and specificity (99.4 %); however, in our study the test had a lower sensitivity (77.8 %) and specificity (95.7 %), and the PPV and NPV were 87.5 % and 91.8 %, respectively.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of different immunoassays to detect specific antibodies to Echinococcus spp. in human sera

2020

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SummaryHuman echinococcosis, one of the most serious of parasitic zoonoses, is caused by the larval stages of taeniid cestodes of the genus Echinococcus. The study aimed to assess the reliability of the detection of specific antibodies to E. multilocularis and E. granulosus s.l. in human sera and to compare their diagnostic potential for their utilization in the practice. In the study, the somatic antigen of E. multilocularis (AgEm), antigen B (AgB), and the hydatid fluid antigen of E. granulosus and two commercial ELISA kits – Echinococcus granulosus (Bordier Affinity Products, Crissier, Switzerland) and NovaLisaTMEchinococcus IgG (NovaTec Immunodiagnostica, Germany) – were compared. Sera of patients with alveolar and cystic echinococcosis, and with different parasitic/other infections were used to evaluate the sensitivity, specificity and cross-reactivity of in-house and commercial ELISA methods. AgEm presented the highest values regarding the diagnostic indicators, showing 100 % specificity and 90.0 % sensitivity. The tests for serological diagnostics of cystic echinococcosis were less sensitive and specific. The Echinococcus granulosus kit had 83.8 % specificity and 88.2 % sensitivity, while AgB and AgHF showed 85.0 % and 86.3 % specificity, and 76.5 % and 100 % sensitivity, respectively. NovaLisaTMEchinococcus IgG proved to have 95.7 % specificity and 77.8 % sensitivity. The results point out that the combination of different serological tests and approaches in accordance with clinical and imaging findings is still essential to prove the correct diagnosis in suspected patients.

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“…Spezifische AK steigen 4-6 Wochen postoperativ an und fallen dann langsam über 12 bis 18 Monate ab. Bis zur Seronegativität kann es zwischen 3 und 7 Jahre dauern [8,11,12]. In der Akutsituation ist sie in aller Regel nicht verfügbar, sodass die Diagnose durch die Klinik und die Bildgebung zu stellen ist.…”

Section: Diskussionunclassified

Anaphylaxie bei rupturierter Echinokokkuszyste

Friebe

Düweler

Theurer

2020

Dtsch Med Wochenschr

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Zusammenfassung Anamnese und klinischer Befund Wir berichten über eine 27-jährige syrische Patientin, die aufgrund eines Kollapses in die Notaufnahme kam. Die Anamnese war praktisch nicht zu erheben, sodass die klinische Symptomatik führend war. Untersuchungen und Diagnose Es bestand ein Schock, mit einem Exanthem einhergehend. Zusätzlich fiel perioral Hämatin auf. Es erfolgte eine Sonografie mit Nachweis freier intraabdomineller Flüssigkeit sowie einer unklaren Veränderung im Oberbauch. Eine Ösophagogastroduodenoskopie erbrachte einen Ulkusnachweis, erklärte aber nicht das Geschehen. Die Computertomografie des Abdomens zeigte eine rupturierte Zyste. Therapie und Verlauf Durch eine antiallergische Therapie erfolgte die Stabilisierung. Unter dem Verdacht einer Echinokokkuszyste aufgrund der Herkunft der Patientin und des Verlaufs wurde nach Gabe von Albendazol die Leberteilresektion durchgeführt. Der makroskopische Befund sowie die Histologie bestätigten den Verdacht. Folgerung Eine unklare klinische Symptomatik, die mit einem Schock einhergeht, sollte bei Ausschluss einer Sepsis oder Blutung immer eine allergische Reaktion berücksichtigen. Kommt es zu einer Anaphylaxie, so ist immer eine Echinokokkose differenzialdiagnostisch miteinzubeziehen.

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The Availability of Echinococcus IgG ELISA for Diagnosing Pulmonary Hydatid Cysts

Cited by 11 publications

References 0 publications

Hydatid disease among adults and children: it is time to worry!

Hydatid disease among adults and children: it is time to worry!

A comparative study of different immunoassays to detect specific antibodies to Echinococcus spp. in human sera

Anaphylaxie bei rupturierter Echinokokkuszyste

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