The Autopsy and Pathology of Sudden Infant Death Syndrome

Byard, Roger W.

doi:10.20851/sids-24

Cited by 6 publications

(4 citation statements)

References 134 publications

(147 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 Further, some infants are not able to survive the effects of airway obstruction even after short periods. 21,22 Children 1 year and above died from multiple causes linked to their increased mobility, with drowning a major risk along with entanglement in blind cords, falls from height, thermal injuries, etc. Children aged 1-4 years had the highest incidence of drowning deaths (19% of the deaths in this age group), compared to the <1-year-old group (2%) and the 5-10-years-old group (16%).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Five-year review (2014–2019) of paediatric accidental deaths in Cook County, Illinois (USA)

Serinelli¹,

Gitto

Arunkumar

2023

Med Leg J

View full text Add to dashboard Cite

In the USA, intentional and accidental injuries are the most frequent causes of death in children. Many of these deaths could be avoided through preventive measures, and aetiological studies are needed to reduce fatalities. The leading causes of accidental death vary by age. We analysed all paediatric accidental deaths recorded by a busy urban Medical Examiner”s Office in Chicago, Illinois (USA). We searched the electronic database for accidental deaths in children aged under 10 between 1 August 2014 and 31 July 2019. 131 deaths were identified with a preponderance of males and African Americans. This is consistent with ratios of other deaths recorded for this age group (during the same period and area). The leading causes of death were asphyxia due to an unsafe sleeping environment (in subjects <1-year-old), and road traffic accidents/drowning (in subjects >1-year-old). Behaviours, risk factors and environments most likely to contribute to fatal injuries are discussed. Our study highlights the role of forensic pathologists and medico-legal death investigators who identify the causes and circumstances surrounding these deaths. The research results may help from an epidemiological perspective to implement age-specific preventive strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

“…20 Further, some infants are not able to survive the effects of airway obstruction even after short periods. 21,22…”

Section: Discussionmentioning

confidence: 99%

Five-year review (2014–2019) of paediatric accidental deaths in Cook County, Illinois (USA)

Serinelli¹,

Gitto

Arunkumar

2023

Med Leg J

View full text Add to dashboard Cite

show abstract

“…However, many infants were ascribed this default diagnosis without even an autopsy. Significant strides in understanding and characterizing the contributing mechanisms have been facilitated by the development and implementation of the international standardized autopsy protocol for sudden unexplained infant deaths (Byard, ; Dempers et al, ; Krous & Byard, ). Our improved understanding of SIDS has led to preventative approaches (“Back to Sleep”) to diminish sleep related positions that put this vulnerable population at risk (Byard, ; Hauck & Tanabe, ; Krous, ) and even consideration of how to best classify these conditions (Mage, ).…”

Section: Discussionmentioning

confidence: 99%

A standardized autopsy protocol for arthrogryposis (multiple congenital contractures)

Oberg

Magaki

Hall

2019

American J of Med Genetics Pt C

View full text Add to dashboard Cite

Arthrogryposis multiplex congenita (AMC) describes disorders with multiple joint contractures that arise from neurological, neuromuscular, or mechanical origin.Although impaired fetal movement is the typical clinical presentation, the etiology underlying this phenotype for a number of conditions remains unknown. In an effort to better characterize and define the etiologies underlying these disorders, we recommend a standardized autopsy protocol that will allow for appropriate diagnosis and a methodical approach for examination that will facilitate subsequent study by investigators across disciplines. To further support investigation, we have also established an AMC autopsy registry to bank tissue obtained at autopsy for subsequent study. K E Y W O R D S arthrogryposis multiplex congenital, autopsy, pathoetiology, protocol

show abstract

“…Retention of tissue for genetic studies is especially important in children as they are more likely to have potentially inherited cardiomyopathies or structurally normal hearts that may have underlying genetic abnormalities [9,22]. Cases of the Sudden Infant Death Syndrome (SIDS) are usually dissected by specialist pathologists, following protocols that aim to identify risk factors for asphyxia and potential infective agents [24,25]. In a recent multi-centre study of 419 cases of SIDS 12.6% had a "potentially informative" variant in a targeted analysis of 90 genetic heart disease susceptibility genes [26].…”

Section: Autopsies In Childrenmentioning

confidence: 99%

Autopsy examination in sudden cardiac death: a current perspective on behalf of the Association for European Cardiovascular Pathology

Banner

Basso

Tolkien³

et al. 2020

Virchows Arch

View full text Add to dashboard Cite

In sudden cardiac death, an autopsy is an essential step in establishing a diagnosis of inherited cardiac disease and identifying families that require cardiac screening. To evaluate aspects of post-mortem practice in Europe, a questionnaire was designed and circulated to both clinical and forensic pathologists. There was a 48% response rate and information was obtained from 17 countries. The results showed a wide variety in the management of sudden cardiac death, with a general tendency towards a lack of thorough investigation. In up to 40% of cases, autopsies were not performed in subjects less than 50 years who may have died from cardiac disease. Reasons for this were lack of finance and lack of interest from police, legal authorities, and doctors. Only 50% of pathologists seem to follow a standard protocol for autopsy examination, apparently due to lack of expertise and/or training. When autopsies were performed, histology and toxicology were almost always taken, genetic studies were generally available and retention of the heart for specialist study was usually permitted. Our results suggest that although the standard of practice is appropriate in many centres, many more cases should have autopsies, especially in sudden deaths in subjects less than 50 years.

show abstract

The Autopsy and Pathology of Sudden Infant Death Syndrome

Abstract: The University of Adelaide Press publishes peer reviewed scholarly books. It aims to maximise access to the best research by publishing works through the internet as free downloads and for sale as high quality printed volumes.

Cited by 6 publications

References 134 publications

Five-year review (2014–2019) of paediatric accidental deaths in Cook County, Illinois (USA)

Five-year review (2014–2019) of paediatric accidental deaths in Cook County, Illinois (USA)

A standardized autopsy protocol for arthrogryposis (multiple congenital contractures)

Autopsy examination in sudden cardiac death: a current perspective on behalf of the Association for European Cardiovascular Pathology

Contact Info

Product

Resources

About