The autonomic nervous system in systemic sclerosis. A review

Bertinotti, Luca; Bracci, Stefania; Nacci, Francesca; Colangelo, Nicola; Rosso, Angela Del; Casale, Roberto; Pignone, Alberto Moggi; Matucci‐Cerinic, Marco

doi:10.1007/s10067-003-0812-4

Cited by 26 publications

(22 citation statements)

References 27 publications

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“…Nevertheless, pSS has also been shown to affect multiple nonexocrine organs such as the nervous system and the gastrointestinal (GI) tract. Studies have found signs of autonomic nervous dysfunction (AD) in pSS 1,2 , reminiscent of what has also been reported in other autoimmune diseases such as inflammatory bowel disease 3,4,5,6 , rheumatoid arthritis 7 , systemic sclerosis (SSc) 8 , and systemic lupus erythematosus 9 . Various GI symptoms such as dysphagia, symptoms of gastroparesis, and irritable bowel syndrome (IBS) have been reported to be more common in patients with pSS than in the general pop-ulation 10,11,12 .…”

mentioning

confidence: 95%

Impaired Gastric Emptying in Primary Sjögren’s Syndrome

Hammar¹,

Ohlsson²,

Wollmer³

et al. 2010

J Rheumatol

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mentioning

confidence: 95%

Impaired Gastric Emptying in Primary Sjögren’s Syndrome

Hammar¹,

Ohlsson²,

Wollmer³

et al. 2010

J Rheumatol

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“…It has been hypothesized that microcircle vasculopathy and autonomic nervous system alterations, commonly observed in SSc, are the cause of atrophy of the smooth muscle cells and of the fibrosis that leads to gastric dysmotility [39][40][41][42]. In this regard, an ultrastructural study of the gastric wall showed alterations in the axoplasma of the nerve fibres (reduction of the neurotubules and of the neurofilaments, swelling of the mitochondria, lipofuscin deposits) and accumulation of elastic fibres and collagen around the nerve endings, which separate them from the smooth muscle cells [43].…”

Section: Discussionmentioning

confidence: 99%

Gastric dysmotility after liquid bolus ingestion in systemic sclerosis: an ultrasonographic study

et al. 2011

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Gastric involvement appears quite commonly in systemic sclerosis (SSc). The aim of this study was to evaluate gastric wall motility using ultrasonography, a noninvasive method able to track both filling and emptying of fundus and antrum. The study was performed in 20 SSc patients and 20 healthy control subjects. Gastric filling and emptying were evaluated by transabdominal ultrasonography, measuring changes in fundus and antral areas over a 1-h period after ingestion of a liquid bolus (500 ml of mineral water). Areas of both gastric fundus and antrum at basal evaluation were found to be smaller in SSc patients than in healthy controls. Gastric filling was significantly reduced after ingestion of liquid bolus. Gastric emptying was delayed both in fundus and antrum. No significant differences of gastric wall motility have been observed in different subsets of SSc patients. Our findings show that gastric dysmotility is frequent and severe in SSc patients, contributing to the gastrointestinal disturbances which are very common in this disease.

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“…The association of higher plasma leu-enkephalin levels with loss of digital pulp in SSc patients supports their potential relevance in subsequent tissue remodeling from increased fibrogenic activity. Reported physiologic interactions of cytokines such as transforming growth factor-beta expression and opioid agonists possibly contribute to wound healing (18). Indirectly, lower met-enkephalin levels have been demonstrated to promote apoptosis via the cellular caspase-3 pathway in cultured cells (7).…”

Section: Discussionmentioning

confidence: 99%