The paper represents the ISS-59/60 crew members, main tasks and results of crew training. great attention is paid to the crew activity aboard the Soyuz MS-12 manned transport vehicle (MTV) and ISS. Special attention is paid to extravehicular operations (EVA) performed according to the programs of the RS (Russian Segment) and USOS (US Orbital Segment) of the ISS. The paper also briefly analyzes the implementation of the Russian scientific applied research and experiments program.