The autologous platelet rich fibrin: A novel approach in osseous regeneration after cystic enucleation: A pilot study

Meshram, Vikas; Lambade, Pravin; Meshram, Priyatama; Kadu, Aishwarya; Tiwari, Manish Sevalal

doi:10.4103/0970-9290.176915

Cited by 17 publications

(17 citation statements)

References 2 publications

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“…The mean amount and percentage of newly formed bone volume was higher in the experimental (0.78 cm 3 ; 82.6%) than control group (0.62 cm 3 ; 68.38%). Bone density does not increase, but the difference was not statistically significant.…”

Section: Interventionsmentioning

confidence: 72%

“…Regenerative therapy in oro-dental and maxillo-facial defects is challenging because the oral cavity has several tissues with distinct cell populations (ectodermal and mesodermal), making regenerative procedures more complex [1]. Bone and soft tissue regeneration may be indicated for managing defects subsequent from several conditions, such as congenital defects (cleft lip and palate), alveolar bone resorption, periodontal defects (recession coverage and furcation defects), cystic cavities, bone infection (osteomyelitis), and traumatic bone destruction [1][2][3][4]. Nowadays, the current clinical approaches have several limitations, namely limited self-renewal capacity and/or limited donor supply, risk of immune response, operative time, and costs and donor site morbidity.…”

Section: Introductionmentioning

confidence: 99%

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Platelet-Rich Fibrin in Bone Regenerative Strategies in Orthodontics: A Systematic Review

2020

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Preservation of the alveolar bone is a determinant in the outcome of orthodontic treatment. Alveolar bone defects or a decrease of their height and width may occur due to common reasons such as inflammation, tooth extraction, or cleft lip and palate. The aim of this systematic review was to investigate and appraise the quality of the most up to date available evidence regarding the applications and effects of platelet-rich fibrin (PRF) in orthodontics. This study was carried out according to preferred reporting items for systematic reviews and meta-analyses guidelines using the following databases: Medline via PubMed, Cochrane Library, Web of Science Core Collection and EMBASE. The qualitative assessment of the included studies was performed using Cochrane Risk of Bias tool and ROBINS-I guidelines. Results: From a total of 489 studies, nine studies were selected. The majority of the included studies demonstrate that autogenous anterior iliac graft with PRF had a higher amount of newly formed bone. Furthermore, this review also suggests that the application of platelet derivatives in the extraction socket can accelerate orthodontic tooth movement. Despite the limitations in the included studies, this systematic review suggested that PRF can improve alveolar cleft reconstruction and orthodontic tooth movement.

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Section: Interventionsmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Fibrin in Bone Regenerative Strategies in Orthodontics: A Systematic Review

2020

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“…The results of the presented research indicate that the application of CGF material in oral surgery procedures such as teeth extractions reduces the intensity of post-operative alignments. Also Singh et al and Meshram et al concluded that PRF offers many advantages such as decrease of the frequency of intraoperative and postoperative bleeding, promotion of more rapid soft tissue healing and rapid vascularization of the healing tissue by delivering growth factors [7,11]. In conclusion, use of CGF in intraosseous bone defects can result in successful bone formation as it promotes faster regeneration because of gradual release of growth factors lodged in the fibrin matrix.…”

Section: Healing Process Pointsmentioning

confidence: 97%

The influence of application of concentrated growth factors on post-operative complications – in vivo split-mouth study

Gnatek¹,

Janas-Naze²

2019

jos

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Introduction: New methods of tissue regeneration revealed a new preparation called CGF -concentrated growth factors. CGF belong to the group of platelet-reach plasma preparations, obtained by blood collecting and its centrifugation. Objectives: The aim was to evaluate the influence of CGF application in post-operative soft tissue and bone defects on post-operative complications and wound healing. Material and methods: The research was conducted in twenty patients with a symmetric single tooth (single or multi-root) qualified for extraction. On one side of the dental arch, the post-operative region was filled with CGF material, while on the other side it was left to heal by standard primary intention. Pain, swelling, alveolar osteitis, use of antibiotics, analgesics intake and wound healing were evaluated in the post-operative period. Results: The risk associated with the occurrence of pain classified higher on the Numeric Rating Scale (NRS) than the given category increased 3.4 times if the alveolus was not filled with CGF (p < 0.05). The risk of swelling on a given day after surgery dropped about 44 times when CGF was applied (p < 0.05, p < 0.01, p < 0.05). In cases where the alveolus was filled with CGF, the use of the membrane reduced the risk of edema by 7.5 times in the seven-day period after surgery. Filling the alveolus with CGF resulted in a 5.7-fold decrease in the risk of having to use antibiotics after tooth extraction (p < 0.01). The possibility for complete healing of the alveolus up to the seventh day after surgery was about 5.5 times lower when the alveolus was not filled with CGF (p < 0.05). Conclusion:The filling of a post-operative defect with CGF reduces the frequency and intensity of post-operative pain, swelling, antibiotic therapy intake and the occurrence of facial edema, which improves the quality of life in the post-operative period.

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“…[7] Bone regeneration after periapical surgery is influenced by four critical factors -primary wound closure, angiogenesis as a blood supply and source of undifferentiated mesenchymal cells, space maintenance and stability of wound (PASS Principle). [8] PRF helps to obtain fibrin membranes enriched with platelets and growth factors. PRF releases autologous growth factors gradually for atleast 1 week and upto 28 days.…”

Section: Discussionmentioning

confidence: 99%

Management of Open Apex in Maxillary Canine Associated with Large Periapical Cyst: A Case Report

Aggarwal¹,

K²

2016

IOSR

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The autologous platelet rich fibrin: A novel approach in osseous regeneration after cystic enucleation: A pilot study

Abstract: The use of PRF in management of cystic lesions seems to be a novel therapeutic approach promoting faster osseous regeneration within 6 months postoperatively however further study is required with larger sample size and with a control group.

Cited by 17 publications

References 2 publications

Platelet-Rich Fibrin in Bone Regenerative Strategies in Orthodontics: A Systematic Review

Platelet-Rich Fibrin in Bone Regenerative Strategies in Orthodontics: A Systematic Review

The influence of application of concentrated growth factors on post-operative complications – in vivo split-mouth study

Management of Open Apex in Maxillary Canine Associated with Large Periapical Cyst: A Case Report

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