The Australian Register: Current Research and Future Role <sup>a</sup>

Dm, Saunders; Mathews, M. R.; Lancaster, Paul

doi:10.1111/j.1749-6632.1988.tb22237.x

Cited by 44 publications

(29 citation statements)

References 6 publications

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“…Past investigators have looked at this issue with regard to preterm delivery (PTD), low birth weight (LBW) and perinatal mortality. Saunders et al [23] appears to have been the earliest in the post IVF era. Their findings were published in a preliminary report on the first 2 years of statistics from the Australian IVF Register.…”

Section: Risk Associated With Subfertilitymentioning

confidence: 96%

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A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

Rimm

Katayama

Katayama³

2011

J Assist Reprod Genet

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Objective To estimate the effect of assisted reproductive technology (ART) on major malformation (MM) rate in ART offspring independent of the effect of subfertility on MM. Design Meta-analysis. Methods This meta-analysis is based on our previously published meta-analysis of observational studies evaluating the relationship between ART treatment and MM rates, as well as recent research by Zhu et al. to estimate the impact of subfertility alone on MM in subfertile couples conceiving spontaneously. Results The overall odds ratio for MM in our original metaanalysis, in which all studies used apparently inappropriate control groups of "normal" populations, was 1.29 (95% CI 1.01-1.67). Here we attempted to estimate the risk of subfertility and used this estimate to perform an adjusted meta-analysis. Zhu et al. found that about 40% of the odds of MM was due to subfertility. When we took Zhu's finding into account, the adjusted odds ratio in the meta-analysis was 1.01 (95% CI 0.82-1.23). Conclusions Our study suggests ART does not increase the risk of MM as much as previously reported. More research is needed to quantify the underlying risk of subfertility and separate it from the risk associated with ART. Physicians who counsel subfertile couples should recognize that previous studies of MM rates in ART patients probably overestimated the risk.

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Section: Risk Associated With Subfertilitymentioning

confidence: 96%

“…However, many investigators [23][24][25][26][27] have suggested that underlying subfertility may have an impact on ART outcomes, separate from the putative impact of the ART treatment itself.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

Rimm

Katayama

Katayama³

2011

J Assist Reprod Genet

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“…There has always been a concern as to whether the infants resulting from these procedures face an increased risk of major malformation (MM) (1,2). A number of studies have addressed this issue but the results vary widely.…”

Section: Introductionmentioning

confidence: 99%

A Meta-Analysis of Controlled Studies Comparing Major Malformation Rates in IVF and ICSI Infants with Naturally Conceived Children

Rimm

Katayama²,

Diaz

et al. 2004

J Assist Reprod Genet

250

120

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Purpose : To estimate the risk of major malformations in IVF and ICSI infants. Methods : Forty-four studies published in English since 1990 where the major malformation rate for IVF or ICSI cases was compared to an appropriate control group were reviewed. Nineteen studies met all selection criteria. In addition, a quality score was developed to assess each study based on sample size, timing of diagnosis, appropriateness of control group and other factors. Results : In 19 studies, the major malformation rates ranged from 0-9.5% for IVF; 1.1-9.7 for ICSI; and 0-6.9% in the control groups. When ICSI was compared to IVF, and multiple births compared to singleton, there were no statistically significant differences. When data from 16 studies involving 28,524 IVF infants and 2,520,988 spontaneously conceived controls and 7 studies involving 7234 ICSI infants and 978,078 controls were pooled, we found an overall odds ratio for the 19 studies of 1.29 (95% CI 1.01-1.67). Conclusions : The overall odds ratio of 1.29 was statistically significant at the 5% level. These results may be useful for counseling ART patients and properly designing the consent forms used for ART procedures. It is not clear whether this risk is due to the procedures used in ART. We found that some of these studies have design flaws. All of them lacked an appropriate control group, i.e. infertile patients conceiving spontaneously. These flaws may create biases that would in almost all instances increase the risk of major malformations in the study group. Further research with better designed studies will likely result in a better estimate of the risk of major malformations associated with IVF and ICSI.KEY WORDS: ART major malformation rate; IVF/ICSI major malformation rate; meta-analysis.

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“…Schieve et al (7) estimated that the rate of low birth weight singletons conceived with assisted reproduction is 2.6 times higher than the general population. Most studies on singleton pregnancies obtained by IVF have revealed relative risks of preterm labor ranging from 1.6 to 2.5, with absolute risk increases of 3.8 to 7.8% (3,(25)(26)(27)(28). A recent meta-analysis including 15 studies comparing IVF singleton pregnancies with those spontaneously conceived corroborated these results, finding statistically significantly higher odds of preterm delivery, low birth weight, and very low birth weight infants when conceived through IVF (5).…”

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confidence: 99%

The effect of infertility and assisted reproduction on first-trimester placental and fetal development

Conway

Liem

Patel

et al. 2011

Fertility and Sterility

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The Australian Register: Current Research and Future Role ^a

Cited by 44 publications

References 6 publications

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

A Meta-Analysis of Controlled Studies Comparing Major Malformation Rates in IVF and ICSI Infants with Naturally Conceived Children

The effect of infertility and assisted reproduction on first-trimester placental and fetal development

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The Australian Register: Current Research and Future Role a

Cited by 44 publications

References 6 publications

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

A Meta-Analysis of Controlled Studies Comparing Major Malformation Rates in IVF and ICSI Infants with Naturally Conceived Children

The effect of infertility and assisted reproduction on first-trimester placental and fetal development

Contact Info

Product

Resources

About

The Australian Register: Current Research and Future Role ^a