We provide a sufficient condition for a linear differential operator with constant coefficients P (D) to be surjective on C ∞ (X) and D ′ (X), respectively, where X ⊆ R d is open. Moreover, for certain differential operators this sufficient condition is also necessary and thus a characterization of surjectivity for such differential operators on C ∞ (X), resp. on D ′ (X), is derived. Additionally, we obtain for certain surjective differential operators P (D) on C ∞ (X), resp. D ′ (X), that the spaces of zero solutions C ∞ P (X) = {u ∈ C ∞ (X); P (D)u = 0}, resp. D ′ P (X) = {u ∈ D ′ (X); P (D)u = 0} possess the linear topological invariant (Ω) introduced by Vogt and Wagner in [27], resp. its generalization (P Ω) introduced by Bonet and Domański in [1].Keywords: Surjectivity of differential operator; Linear topological invariants for kernels of differential operators; Differential operators on vector-valued spaces of functions and distributions; Parameter dependence for solutions of linear partial differential equations 2010 MSC: Primary: 35E10, 46A63. Secondary: 35E20