The auditory evoked potential in the rat—a review

Shaw, N.A.

doi:10.1016/0301-0082(88)90021-4

Cited by 111 publications

(63 citation statements)

References 148 publications

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“…In rat AC, the fast P1/N1 complex presumably has a focal topology and may reflect cortical responses to stimulus-specific and spectrally selective thalamocortical input, whereas the slower waves P2/N2 depend on more widespread corticocortical connections (Shaw, 1988;Barth and Di, 1990;Brett et al, 1996). This spatial dichotomy between the fast and slow waves is supported by Barth et al (1993) and Ohl et al (2000), who both showed that fast P1 and N1 are centered in A1 and that slow P2 and N2 originate in A1 plus secondary AC.…”

Section: Different Network Contribute To the Elfpsmentioning

confidence: 59%

Correlating Stimulus-Specific Adaptation of Cortical Neurons and Local Field Potentials in the Awake Rat

Behrens¹,

Bäuerle²,

Kössl³

et al. 2009

J. Neurosci.

161

128

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Changes in the sensory environment are good indicators for behaviorally relevant events and strong triggers for the reallocation of attention. In the auditory domain, violations of a pattern of repetitive stimuli precipitate in the event-related potentials as mismatch negativity (MMN). Stimulus-specific adaptation (SSA) of single neurons in the auditory cortex has been proposed to be the cellular substrate of MMN (Nelken and Ulanovsky, 2007). However, until now, the existence of SSA in the awake auditory cortex has not been shown. In the present study, we recorded single and multiunits in parallel with evoked local field potentials (eLFPs) in the primary auditory cortex of the awake rat. Both neurons and eLFPs in the awake animal adapted in a stimulus-specific manner, and SSA was controlled by stimulus probability and frequency separation. SSA of isolated units was significant during the first stimulus-evoked "on" response but not in the following inhibition and rebound of activity. The eLFPs exhibited SSA in the first negative deflection and, to a lesser degree, in a slower positive deflection but no MMN. Spike adaptation correlated closely with adaptation of the fast negative deflection but not the positive deflection. Therefore, we conclude that single neurons in the auditory cortex of the awake rat adapt in a stimulus-specific manner and contribute to corresponding changes in eLFP but do not generate a late deviant response component directly equivalent to the human MMN. Nevertheless, the described effect may reflect a certain part of the process needed for sound discrimination.

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Section: Different Network Contribute To the Elfpsmentioning

confidence: 59%

Correlating Stimulus-Specific Adaptation of Cortical Neurons and Local Field Potentials in the Awake Rat

Behrens¹,

Bäuerle²,

Kössl³

et al. 2009

J. Neurosci.

161

128

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“…The lack of reaction to sound stimuli in the three highdose groups was confirmed by recording the brainstem auditory evoked potentials which showed a complete disappearance of all the waves including the first wave which is attributed to the compound action potential of the acoustic nerve or the cochlea itself (Shaw 1988). The histological Fig.…”

Section: Discussionmentioning

confidence: 79%

The Ototoxic Effects Induced in Rats by Treatment for 12 Weeks with 2‐Butenenitrile, 3‐Butenenitrile and cis‐2‐Pentenenitrile

Gagnaire¹,

Marignac²,

Ban³

et al. 2001

Pharmacology & Toxicology

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Brainstem auditory and visual evoked-potentials were studied in male Sprague-Dawley rats during subchronic oral treatment with three unsaturated aliphatic nitriles. The rats were given, by gastric intubation, doses of 10, 20 and 40 mg ¡ kg ª1 3-butenenitrile (allyl cyanide) and 25, 50 and 100 mg ¡ kg ª1 of either cis/trans-2-butenenitrile (crotononitrile) or cis-2-pentenenitrile once a day, 5 days per week for 12 weeks. Oral administration of the three unsaturated nitriles produced deafness and absence of reaction when the animals were subject to droptest. Rats in the high dosage groups exhibited a complete disappearance of the five waves of the auditory evoked-potentials. There was a decrease in the amplitudes of the 2nd component of the auditory evoked-potentials. Those changes were not reversible at the 8th week of the recovery period. A dose-dependent effect on inner and outer hair cells was observed in the organ of Corti. The basal part of the cochlea was the most affected. Though no measurements were made of systemic exposure, a tentative ranking of decreasing ototoxicity of these three unsaturated nitriles might be proposed based on the electrophysiological deficiencies and histological losses observed: 3-butenenitrile Ͼcis-2-pentenenitrile Ͼcis/trans-2-butenenitrile. Moreover, rats treated with those nitriles showed a corneal opacity as well as a decrease in the amplitude and lengthening of the peak latencies of the visual evoked-potentials. These latter changes were reversible by the end of the 8th week of the recovery period and appeared to be related to the opacity of the cornea.

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“…1,2,4,8,18 As formas de se estudar os efeitos da toxicidade coclear têm se dirigido às alterações eletrofisiológicas detectadas pelo Potencial Evocado de Tronco Cerebral (BERA) e Potencial Endococlear. 2,4,5,15,16,[19][20][21] As emissões otoacústicas, detectadas por Kemp (1971) no conduto auditivo externo de humanos, medem o "feedback" de energia biomecânica na contração das células ciliadas externas, que amplifica o pico da "onda viajante" na membrana basilar e têm aplicação clínica na avaliação da integridade auditiva. 16,[21][22][23][24][25] Como a cisplatina atua inicialmente causando lesões nas células ciliadas externas, as emissões otoacústicas seriam um método de avaliação simples e rápido de tais danos, podendo inclusive participar na monitorização de pacientes submetidos a drogas consideradas ototóxicas.…”

Section: Introductionunclassified

Ototoxicidade da cisplatina e otoproteção pelo extrato de ginkgo biloba às células ciliadas externas: estudo anatômico e eletrofisiológico

Hyppolito¹,

Oliveira²,

Rossato³

et al. 2003

Rev. Bras. Otorrinolaringol.

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A Cisplatina é uma potente droga antineoplásica, largamente utilizada para o tratamento do câncer, tanto em adultos quanto em crianças. Dentre seus efeitos colaterais, a ototoxicidade se apresenta como um dos mais importantes e leva à perda auditiva irreversível, bilateral, para as altas freqüências (4KHz#8KHz). Estudos têm tentado identificar drogas que, associadas à cisplatina possam atuar como otoprotetores. Sabe-se que o mecanismo da ototoxicidade pela cisplatina está relacionado a alterações nos mecanismos antioxidantes das células ciliadas, principalmente as células ciliadas externas da cóclea. Objetivo: Nossa proposta foi de avaliar através de emissões otoacústicas, por produtos de distorção (EOAPD) e por microscopia eletrônica de superfície (ME), a ação do extrato de ginkgo biloba (EGB 761), que tem conhecida ação antioxidante, como possível otoprotetor, utilizando como modelo experimental cobaias albinas. Forma de estudo: Experimental. Material e método: Observamos EOAPD presentes pré e pós tratamento no grupo EGB (100 mg/Kg/dia via oral) e 90 minutos após cisplatina (80 mg/Kg/dia via intraperitoneal) por 8 dias. Resultado: Houve também manutenção da arquitetura ciliar nas células ciliadas externas em todas as espiras da cóclea, enquanto que no grupo tratado somente com cisplatina (80 mg/ Kg/dia via intraperitoneal) por 8 dias, houve desaparecimento das EOAPD pós tratamento, com desaparecimento dos cilios das células ciliadas externas e distorção na arquitetura dos cílios remanescentes à ME. Conclusão: Concluímos que a EGB, por sua ação antioxidante, atua como fator otoprotetor à ototoxicidade pela cisplatina, devendo ser testada tal ação na prática clínica em pacientes que utilizam a cisplatina, pois o uso do EGB está extremamente difundido no tratamento de diferentes doenças. ci splatin is an antineoplastic drug for cancer treatment in children and adults. The side effects of cisplatin ototoxycity are important with irreversible auditory and bilateral damage to high frequencies (4kHz -8 kHz). Reports recognize some drugs that are associated with cisplatin to obtain an otoprotector effect. The ototoxycity mechanisms of cisplatin are related to injury of conduct the hair cell oxidation mechanism, with particular injury to outer hair cells. Aim: We intend to studies using otoacoustic emissions -distortion products (DPOEA) and scanning microscopy to verify the action of ginkgo biloba (GBE-761) that has well known antoxidizing characteristics, that can function like otoprotector effects. Study design: Experimental. Material and method: We use an experimental guinea pig model. We found DPOEA positive before and after treatment in the GBE group (100 mg/ Kg/ day -oral) and after 90 minutes cisplatin (8,0 mg/ Kg/ day -intraperitoneal -8 consecutive days). Results: The normal cilium architecture of outer hair cells was supported in all cochlear spirals and in the group treated only with cisplatin (8,0 mg/ Kg/ day -intraperitoneal -8 consecutive days), the DPOEA was not present and strong injury to cilium of out...

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The auditory evoked potential in the rat—a review

Cited by 111 publications

References 148 publications

Correlating Stimulus-Specific Adaptation of Cortical Neurons and Local Field Potentials in the Awake Rat

Correlating Stimulus-Specific Adaptation of Cortical Neurons and Local Field Potentials in the Awake Rat

The Ototoxic Effects Induced in Rats by Treatment for 12 Weeks with 2‐Butenenitrile, 3‐Butenenitrile and cis‐2‐Pentenenitrile

Ototoxicidade da cisplatina e otoproteção pelo extrato de ginkgo biloba às células ciliadas externas: estudo anatômico e eletrofisiológico

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