The attributable cost, length of hospital stay, and mortality of central line-associated bloodstream infection in intensive care departments in Argentina: A prospective, matched analysis

Rosenthal, Victor

doi:10.1016/j.ajic.2003.03.002

Cited by 176 publications

(131 citation statements)

References 36 publications

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“…Typically, antifungal treatments are long, which increases the length of hospital stay and the cost of drugs. [13][14][15][16] In a recent article, Bloos et al demonstrated the higher financial cost in patients hospitalized due to candidemia compared with sepse caused by other agents. 15 Because of the inconvenience caused by this disease, each health care institution should know the profile of agents that cause fungemia in its population.…”

mentioning

confidence: 99%

Prevalence of fungemia in a tertiary hospital: Analysis of the last decade

Castro

Schütze

Bücker

et al. 2016

Rev. Assoc. Med. Bras.

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mentioning

confidence: 99%

Prevalence of fungemia in a tertiary hospital: Analysis of the last decade

Castro

Schütze

Bücker

et al. 2016

Rev. Assoc. Med. Bras.

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“…In France, the National Nosocomial Infection Survey estimated an incidence rate of CVC-related BSI of 1.23 per 1000 cathetersdays (Tacconelli et al, 2009) and another European study reported a 43.9% mortality of BSI in the ICU (Pratikaki et al, 2009). In South America, an Argentinian study found a 2.92% incidence of CVCrelated BSI in the ICU, with a crude mortality of 52.4% (Rosenthal et al, 2003). A Brazilian study also conducted in the ICU setting reported a 1.5% frequency of CVC-related BSI with a 40% overall mortality (Mesiano and Merchan-Haman, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…In South America, there are fewer studies addressing this issue. In an Argentinian 5 year study involving 6 hospitals, it was reported that CVCrelated BSI complicated 2.92% of all ICU admissions, increased hospitalization length by 11.9 days and resulted in a 24.6% excess mortality (Rosenthal et al, 2003). A Brazilian study carried out over a period of 11 months in 7 public ICUs in the Federal District found a 6.4% frequency of overall BSI and a 1.5% frequency of CVC-related BSI.…”

Section: Ajidmentioning

confidence: 99%

Factors Associated With Mortality Among Patients With Central Venous Catheter-Related Bloodstream Infection in an Intensive Care Unit

Rocha¹

2012

American Journal of Infectious Diseases

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Central venous catheterization is a common practice in the management of critically ill patients and is associated with various complications, such as Bloodstream Infections (BSI), which are major determinants of increased morbidity, mortality and healthcare expenses. Few studies have addressed factors that predict mortality in patients with this complication. The aim of this study was to investigate factors associated with mortality in patients with Central Venous Catheter (CVC)-related BSI in an intensive care unit of a tertiary care hospital in the Federal District, Brazil. This was a retrospective and observational study, in which all CVC-related BSI that occurred between January 2008 and December 2010 were reviewed. We obtained demographic, clinical, biochemical and microbiological data from medical records and investigated its association with mortality during ICU stay. There were 4,504 ICU admissions during the study period and 68 were complicated by CVC-related BSI (4.09 per 1000 catheter-days), most due to gram-negative organisms (45.6%). Overall mortality was 59.7%. Death risk was significantly associated with mechanical ventilation (OR 27.8, p<0.001), the mean number of invasive devices other than the CVC (1.44 Vs 2.37 in controls Vs cases, p<0.001) and increased serum levels of urea (mean value of 44.2 mg dL −1 in survivors vs. 73.9 mg dL −1 in nonsurvivors, p = 0.001). Mortality was not associated with other clinical or biochemical features, neither with microbiological variables, although lethality was high among patients with gram-positive infections (77% Vs 58.33% for fungi and 54.83% for gram-negative). CVC-related BSI was associated with high absolute mortality, which was predicted by mechanical ventilation and a higher number of invasive devices other than the CVC. Knowledge of local factors predictive of mortality is critical for planning strategies to reduce death risk associated with this complication.

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“…Direct costs attributable to nosocomial bacteremia have been estimated to be US$3200/patient. 20 Estimated costs attributable to catheter-related bacteremia have been variably reported: $4888/patient in an Argentinean study of intensive care unit (ICU) patients with CR-BSI, 21 US$6005-9738/patient for infection related to short-term CVCs, 22 and US$25000/ patient for ICU patients with CR-BSI. 23 Using US data, Wenzel and Edmond 24 estimated the impact of nosocomial bloodstream infections on mortality.…”

Section: Catheter-related Bloodstream Infectionsmentioning

confidence: 99%

Catheter‐related bloodstream infections in hematology

Worth

Slavin

Brown

et al. 2007

Cancer

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THE NEED FOR SURVEILLANCE AND LIMITATIONS OF CURRENT METHODSTunneled and nontunneled central venous catheters (CVCs) are necessary to facilitate treatment of many hematologic disorders, but catheter-related bloodstream infections (CR-BSIs) are an important cause of morbidity and mortality, and may lead to interruptions in planned therapy for malignancy or increases in length of hospital stay. In immunocompromised populations with neoplastic disease, risks for infection are not uniform, 1 and increased risk for bloodstream infections in patients with hematological malignancy may be related to the underlying malignancy, chemotherapy-induced granulocytopenia, breaches in skin or mucosal integrity, or invasive procedures. 2,3Standardized surveillance measures have not been used to assess interventions with potential impact on the epidemiology of CR-BSIs. For example, widespread use of antibiotic lock therapy,

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The attributable cost, length of hospital stay, and mortality of central line-associated bloodstream infection in intensive care departments in Argentina: A prospective, matched analysis

Cited by 176 publications

References 36 publications

Prevalence of fungemia in a tertiary hospital: Analysis of the last decade

Prevalence of fungemia in a tertiary hospital: Analysis of the last decade

Factors Associated With Mortality Among Patients With Central Venous Catheter-Related Bloodstream Infection in an Intensive Care Unit

Catheter‐related bloodstream infections in hematology

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