The attenuated Salmonella vaccine approach for the control of Helicobacter pylori-related diseases

Comparative proteomics and immunoproteomics of Helicobacter pylori related to different gastric pathologies☆

“…So far, mainly conserved or very abundant antigens of H. pylori including urease A and B subunits, catalase, CagA, VacA, the GroES homologue HspA and NapA have been analyzed for their protective or therapeutic potentials in animal studies. All these antigens have been recognized by serum antibodies, even if none have been shown to be protective in humans [4][5][6][7][8][9]. Thus, the characterization of further antigens seems important to evaluate valuable combinations of antigens for vaccine purposes.…”

The Development of Therapeutic and Preventive Vaccines for Gastric Cancer andHelicobacter pylori

“…of an immune response. Numerous H. pylori immunization strategies are currently under development, including vaccines incorporating immunostimulatory adjuvants, such as cholera toxin and/or E. coli heat-labile toxin (77,78), live attenuated vectors (79,80), DNA immunization (81), encapsulated nanoparticles (82), etc. Mucosal (oral) and nonmucosal antigen delivery has also been studied in an effort to identify the most efficacious route of immunization (83).…”

Vacuna atenuada de Salmonella como vector de antígenos heterólogos

“…Igualmente, la vacuna atenuada SL3261 (pYZ97) expresó un nivel significativamente alto de ambas subunidades como se demostró en los immunoblots (53)(54). La inmunogenicidad de esta vacuna se evaluó inmunizando dos tipos de cepas de ratones, BALBlc y C57BL6, por vía oral, con una dosis única de 1x109 unidades formadoras de colonias (UFC) en un volumen total de 100 ul.…”