Understanding the effect of messages that appear in the mediated environment in terms of their effectiveness is challenging. Serious, careful evaluation is very expensive in time and in financial and human resources. Efficient procedures for evaluating the effectiveness of messages for the purposes of persuasion would be a useful tool for those designing public health campaigns, political and social issue campaigns, and certainly for researchers seeking to evaluate various types of message effects as they undertake theory testing. The purpose of this entry is to suggest an efficient, reliable, and valid protocol to assess message effectiveness that involves quantitative methods (1) using multiple messages, (2) recruiting evaluators from the target population, (3) using valid and reliable measures for evaluation, (4) exposing an evaluator to multiple messages, and (5) ensuring enough (2) evaluations per message for stability.