The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies

Regulation of c-met expression by transcription repressor Daxx

“…In addition, Daxx forms a complex with protein ATRX and this complex displays chromatin-remodeling activity (Xue et al, 2003;Ishov et al, 2004;Tang et al, 2004). Besides chromatin remodeling, ATRX also possesses DNA methylation activity (Gibbons et al, 2000); DNA methylation is generally associated with repression of transcription (reviewed in Baylin and Ohm, 2006).…”

The double face of the histone variant H3.3

“…ATRX localizes to pericentric heterochromatin in HeLa cells [68] and was previously shown to physically associate and form a complex with DAXX in vivo [69]. DAXX was recently shown to exhibit chaperone activity and directly interact with H3.3 in a tighter manner than with H3.1 in vitro [48].…”

-Thalassemia, Mental Retardation, and Myelodysplastic Syndrome

“…Immunocytochemical analysis and indirect immunolocalization show that both isoforms are nuclear proteins that predominantly associate with heterochromatin (in interphase and metaphase) (McDowell et al 1999;Garrick et al 2004). A significant proportion of ATRX (but not ATRXt) is also found in nuclear speckles (called promyelocytic leukemia [PML] bodies) in human cells (Xue et al 2003). One additional, striking finding in human metaphase preparations is that ATRX antibodies localize to the short arms of acrocentric chromosomes associated with the rDNA arrays .…”