The Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER)

Abstract

years (56% female). Persistent-permanent AF was found to be the most common type of non-valvular AF (78%). The most common comorbid disorder was hypertension (73%). It was found that oral anticoagulant therapy was used by 40% of all patients, 37% of whom had effective INR (2.0-3.0). Upon multivariate analysis, age was found to be the only independent predictor of stroke among the variables' effects on thromboembolic events that created CHA 2 DS 2 -VASc abbreviations (OR 1.026, p < 0.001). Conclusions: These results suggest that stroke risk scores should be thoroughly heeded based on guidelines, and that anticoagulation must be applied according to their guidance. (Cardiol J 2013; 20, 4: 447-452)

Evaluation of the impact of warfarin time in therapeutic range on outcomes of patients with atrial fibrillation in Turkey: Perspectives from the observational, prospective WATER Registry

“…However, a large percentage of AF patients receive suboptimal care. Few studies have been conducted with similar prevalence and incidence ratios in the Turkish population [13,14]. Notwithstanding this fact, a cohort study pointed www.cardiologyjournal.org out that only 42% of eligible patients received oral anticoagulants [13].…”

Epidemiology, anticoagulant treatment and risk of thromboembolism in patients with valvular atrial fibrillation: Results from Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER)

“…Even so, most studies investigating AF and stroke have been mostly performed with non-valvular AF patients. This has led to a paucity of detailed epidemiological information regarding risk factors for thromboembolism in patients with valvular AF [3][4][5][6][7][8][9][10]. Although there was a multicenter study that investigated the epidemiology of heart valve diseases in Turkey, this study did not focus on valvular AF patients [11].…”

Current approaches in atrial fibrillation treatment

“…Yakın zamanlarda yapılan çok merkezli epidemiyolojik bir çalışma olan 'AF-TER' (Atrial Fibrillation in Turkey: Epidemiologic Registry) çalışmasında ülkemizde valvuler patlojilere bağlı AF prevelansı %22 bulunup, gelişmiş ülkelere göre bu oran daha fazla bulunmuştur (38). ''AFTER'' çalışmasında inme prevelansı %15 bulunmuş olup kadın cinsiyette bu oran erkek cinsiyete oranla 1.5 kat fazla bulunmuştur (38). Yine ülke-mizde yapılan önemli çalışmalardan ''TEKHARF'' çalışmasında kadın cinsiyette inme riski 1.5-2 kat fazla bulunmakla beraber bu bulgular avrupa ve amerika klavuzlarıyla uyumludur (2).…”

“…Yine ülke-mizde yapılan önemli çalışmalardan ''TEKHARF'' çalışmasında kadın cinsiyette inme riski 1.5-2 kat fazla bulunmakla beraber bu bulgular avrupa ve amerika klavuzlarıyla uyumludur (2). Valvuler AF'de hala elimizdeki en büyük silah warfarin sodium olmakla beraber ''AFTER'' çalışmasında malesef optimal düzeyler sadece %41.3 hastada sağla-nabildiği görülmüştür (38). Yeni OAK'lardan olan dabigatran RE-ALİGN çalışmasında protez kapaklarda denenmiş olup, çalışma dabigatran kolunda kanama ve kapak trombozunun daha sık görülmesi üzerine erken sonlandırılmıştır.…”