The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction

Wang, Qian; Kong, Ying; Lin, Song; Wu, De; Hu, Jian; Huang, Lang; Zang, Wen-Si; Li, Xiaowen; Yang, Jian‐Ming; Gao, Tianming

doi:10.1007/s12264-021-00726-4

Cited by 9 publications

(9 citation statements)

References 43 publications

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“…Astrocytes are thought to regulate neuronal excitability by releasing ATP in a calcium‐dependent manner 88 . The inositol 1,4,5‐trisphosphate receptors (IP3Rs) located on the endoplasmic reticulum of cells are key mediators in regulating the release of calcium ions 43 . The protein encoded by the ITPR2 gene belongs to the IP3R family.…”

Section: Neurological Mechanism Of Eatp In Depressionmentioning

confidence: 99%

“… 40 , 41 Substantial evidence from animals suggests that insufficient ATP release from astrocytes may contribute to the development of MDD. 42 , 43 , 44 Clinical studies on depression also indicate a potential reduction in cellular ATP levels, which could also be observed in rodents with corticotropin‐releasing hormones and stress‐induced depressive‐like behavior. 45 Furthermore, studies have shown supplementing ATP can alleviate stress‐induced depressive‐like behaviors in mice, especially in those with Apolipoprotein E4 (APOE4) targeted replacement.…”

Section: Introductionmentioning

confidence: 99%

“…eATP is an important medium of astrocyte‐neuron communication and has been linked to depressive‐like disorders in rodent models 40,41 . Substantial evidence from animals suggests that insufficient ATP release from astrocytes may contribute to the development of MDD 42–44 . Clinical studies on depression also indicate a potential reduction in cellular ATP levels, which could also be observed in rodents with corticotropin‐releasing hormones and stress‐induced depressive‐like behavior 45 .…”

Section: Introductionmentioning

confidence: 99%

“…Anti‐depressant fluoxetine acted on astrocytes and mediated its therapeutic effects by facilitating vesicular nucleotide transporter (VNUT)‐dependent ATP exocytosis 56 . ATP release was elevated in calorie‐restricted mice but decreased in IP3R2‐KO mice in depression‐related brain regions 43 . P2X2R 57,58 and P2X4R 59,60 may play an important role in anti‐depressant effects.…”

Section: Introductionmentioning

confidence: 99%

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The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression

Wang,

Huang,

et al. 2024

CNS Neurosci Ther

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BackgroundDepression is a prevalent psychiatric disorder with high long‐term morbidities, recurrences, and mortalities. Despite extensive research efforts spanning decades, the cellular and molecular mechanisms of depression remain largely unknown. What's more, about one third of patients do not have effective anti‐depressant therapies, so there is an urgent need to uncover more mechanisms to guide the development of novel therapeutic strategies. Adenosine triphosphate (ATP) plays an important role in maintaining ion gradients essential for neuronal activities, as well as in the transport and release of neurotransmitters. Additionally, ATP could also participate in signaling pathways following the activation of postsynaptic receptors. By searching the website PubMed for articles about “ATP and depression” especially focusing on the role of extracellular ATP (eATP) in depression in the last 5 years, we found that numerous studies have implied that the insufficient ATP release from astrocytes could lead to depression and exogenous supply of eATP or endogenously stimulating the release of ATP from astrocytes could alleviate depression, highlighting the potential therapeutic role of eATP in alleviating depression.AimCurrently, there are few reviews discussing the relationship between eATP and depression. Therefore, the aim of our review is to conclude the role of eATP in depression, especially focusing on the evidence and mechanisms of eATP in alleviating depression.ConclusionWe will provide insights into the prospects of leveraging eATP as a novel avenue for the treatment of depression.

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Section: Neurological Mechanism Of Eatp In Depressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression

Wang,

Huang,

et al. 2024

CNS Neurosci Ther

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“…Preclinical studies in rodent models of depression consistently find that calorie restriction or intermittent fasting exerts antidepressant-like effects [ 68 , 69 , 70 , 71 ]. Evidence suggests that increased antioxidant and anti-inflammatory mediators, mitochondria biogenesis, decreased serotonin, and increased ATP, orexin, and ghrelin may be involved in the mechanism of action of calorie restriction [ 68 , 69 , 70 , 71 , 72 ]. In one particularly interesting study, acute fasting for nine hours reduced depressive behavior in mice in the forced swim test [ 70 ].…”

Section: Affective Disordersmentioning

confidence: 99%

Dietary and Metabolic Approaches for Treating Autism Spectrum Disorders, Affective Disorders and Cognitive Impairment Comorbid with Epilepsy: A Review of Clinical and Preclinical Evidence

Iyer,

Yeh,

Netzel

et al. 2024

Nutrients

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Epilepsy often occurs with other neurological disorders, such as autism, affective disorders, and cognitive impairment. Research indicates that many neurological disorders share a common pathophysiology of dysfunctional energy metabolism, neuroinflammation, oxidative stress, and gut dysbiosis. The past decade has witnessed a growing interest in the use of metabolic therapies for these disorders with or without the context of epilepsy. Over one hundred years ago, the high-fat, low-carbohydrate ketogenic diet (KD) was formulated as a treatment for epilepsy. For those who cannot tolerate the KD, other diets have been developed to provide similar seizure control, presumably through similar mechanisms. These include, but are not limited to, the medium-chain triglyceride diet, low glycemic index diet, and calorie restriction. In addition, dietary supplementation with ketone bodies, polyunsaturated fatty acids, or triheptanoin may also be beneficial. The proposed mechanisms through which these diets and supplements work to reduce neuronal hyperexcitability involve normalization of aberrant energy metabolism, dampening of inflammation, promotion of endogenous antioxidants, and reduction of gut dysbiosis. This raises the possibility that these dietary and metabolic therapies may not only exert anti-seizure effects, but also reduce comorbid disorders in people with epilepsy. Here, we explore this possibility and review the clinical and preclinical evidence where available.

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Extracellular ATP is a homeostatic messenger that mediates cell‒cell communication in physiological processes and psychiatric diseases

Chen,

Lin,

Jin

et al. 2024

Biological Psychiatry

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The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction

Cited by 9 publications

References 43 publications

The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression

The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression

Dietary and Metabolic Approaches for Treating Autism Spectrum Disorders, Affective Disorders and Cognitive Impairment Comorbid with Epilepsy: A Review of Clinical and Preclinical Evidence

Extracellular ATP is a homeostatic messenger that mediates cell‒cell communication in physiological processes and psychiatric diseases

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