The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma

Zheng, Tao; Yu, Jinho; Oh, Min Hee; Zhu, Zhou

doi:10.4168/aair.2011.3.2.67

Cited by 335 publications

(218 citation statements)

References 75 publications

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“…[8] In adults the clinical picture may be altered: patients presenting with hand dermatitis were possibly exposed to additional insults such as irritants (wet work, detergents, chemicals and solvents) or head and neck involvement. [12] The concept of the 'atopic march' , where children with AD develop mucosal forms of atopic disease, [13] has been challenged by some cohort studies. [14] An early wheeze and a specific sensitisation pattern (wheat, cat, mite, soy and birch) were predictors of wheezing at school age in a German-birth cohort study, irrespective of the presence of AD.…”

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confidence: 99%

Epidemiology of atopic dermatitis

Todd

2014

S Afr Med J

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Epidemiological studies on atopic dermatitis, primarily performed in children, have shown that the one-year prevalence rate of symptoms is population and area dependent. The few studies that have been done in South Africa among children of different age groups showed one-year prevalence rates of 1 -13.3%. In adults, the burden of disease is significant. The prevalence rates and age-related percentages of those affected vary between the countries where studies were undertaken. While about 60% of cases show spontaneous clearing by puberty, the condition may recur in adults.

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confidence: 99%

Epidemiology of atopic dermatitis

Todd

2014

S Afr Med J

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“…[2][3][4][5][6][7] Epicutaneous sensitisation to aeroallergens has been thought to be responsible, with subsequent migration of sensitised T cells into the nose and airways, causing upper and lower airway disease. [8,9] Aeroallergen sensitisation is common in AD patients, and in the EPAAC (Early Prevention of Asthma and Allergies in Children) study, 20 -40% of AD patients were sensitised to house-dust mite.…”

Section: Researchmentioning

confidence: 99%

Respiratory comorbidity in South African children with atopic dermatitis

2017

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This article explores the comorbidity between AD, food allergy, aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children. Age-dependent patterns of aeroallergen sensitisation are explored, and indoor v. outdoor aeroallergens are differentiated with regard to risk profiles for comorbid conditions. Background. Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens. Objectives. To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD.Methods. This was a prospective, observational study in a paediatric university hospital in Cape Town, SA. Children with moderate to severe AD, aged 6 months -10 years, were recruited randomly and investigated for food sensitisation and allergy. They were assessed for sensitisation to aeroallergens by the immuno solid-phase allergen chip test. House-dust mite DerP and DerF, dust mite Eur m, Timothy grass, Bermuda grass, tree pollen, mould (Alternaria), cat and dog sensitisation patterns were analysed. Symptoms of asthma and allergic rhinitis were elicited using a questionnaire modified from the International Study of Asthma and Allergies in Childhood study questions. Results. One hundred participants (59 black Africans and 41 of mixed ethnicity) were enrolled (median age 42 months). Of the participants, 39% had symptoms of asthma and 53% symptoms of allergic rhinitis; 89% tested positive to at least one aeroallergen, most commonly house-dust mite DerP or DerF (81%), dust mite Eur m (51%), Timothy grass (36%) and cat (35%). Asthma, allergic rhinitis and aeroallergen sensitisation all increased with increasing age, while food allergy decreased with age. Food allergy was not an independent risk factor for respiratory allergies. Children were sensitised to indoor allergens (house-dust mite, pets) from an early age, while pollen allergies increased with age. Conclusions. In this cohort of SA children with moderate to severe AD, comorbidity with respiratory allergies was high. The prevalence of respiratory allergies increased with age while food allergy decreased with age, in keeping with the pattern of the allergic march. Seasonal allergies increased with age, while house-dust mite and pet allergy peaked in younger children, in keeping with early exposure via a defective skin barrier. Early and effective restoration of the skin barrier in AD may be a target for reducing aeroallergen-related diseases.

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“…But the patient who has a allergic disease frequently has multiple allergic reactions. Furthermore a patient with a prominent allergic disease has a strong chance to have a different allergic disease 15) .…”

Section: ⅰ Introductionmentioning

confidence: 99%

Korean Translation and Validation of the Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ)

Park¹,

Kim²,

Lee³

et al. 2013

The Journal of Korean Oriental Pediatrics

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* ObjectivesIn pediatrics of Korean Medicine, it is crucial to evaluate the overall symptoms of children, especially in the children who have serious troubles in their life. In the era when diagnosis in Korean Medicine is quite suitable to evaluate multiple allergic diseases, and when growing numbers are in needs, development of an objective measurement scale for diagnosis of allergic disease in Korean Medicine became essential. Therefore, in the study, pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) was translated into Korean version with validations on some aspects. MethodsIn this study, we translated and validated the PADQLQ and established psychometric evidence on its utility in Korean children with similar problems. 71 children, age of 6 ～ 18 with allergic disease has participated. ResultsThe internal consistency reliability of the PADQLQ by Cronbach's α was 0.94. In three domains (Practical, Physical, Emotional), the Cronbach's α was 0.77, 0.90 and 0.69. The Spearman's rank correlation coefficient between PADQLQ total score and VAS was 0.75 (p<0.001). And, Structural validity was evaluated by the ANOVA test. QoL differencesof the four groups in the three domains (practical, physical, emotional) were significant. The item discriminative indices were ranged from 0.1651 to 0.8188. ConclusionsKorean version PADQLQ is highly reliable and valid for children with allergic diseases. This is significant to assess the relative seriousness of the allergic diseases and to evaluate the efficacy of different treatments in Korean Medicine.

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The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma

Cited by 335 publications

References 75 publications

Epidemiology of atopic dermatitis

Epidemiology of atopic dermatitis

Respiratory comorbidity in South African children with atopic dermatitis

Korean Translation and Validation of the Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ)

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