The Atomic Force Microscope as a New Microdissecting Tool for the Generation of Genetic Probes

Thalhammer, Stefan; Stark, Robert W.; Müller, Shirley A.; Wienberg, Johannes; Heckl, Wolfgang M.

doi:10.1006/jsbi.1997.3869

Cited by 99 publications

(59 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metaphase chromosomes have been microdissected, and the extracted material was used for biochemical evaluation (Thalhammer et al, 1997;Xu and Ikai, 1998). As illustrated in Fig.…”

Section: Afm As a Nanomanipulator And Dissecting Toolmentioning

confidence: 99%

Atomic Force Microscopy in Cytogenetics

Thalhammer¹,

Heckl²

2005

Force Microscopy

Self Cite

View full text Add to dashboard Cite

“…Metaphase chromosomes have been microdissected, and the extracted material was used for biochemical evaluation (Thalhammer et al, 1997;Xu and Ikai, 1998). As illustrated in Fig.…”

Section: Afm As a Nanomanipulator And Dissecting Toolmentioning

confidence: 99%

Atomic Force Microscopy in Cytogenetics

Thalhammer¹,

Heckl²

2005

Force Microscopy

Self Cite

View full text Add to dashboard Cite

“…Beside imaging, force spectroscopy has been used to reveal biochemistry processes on a molecular level (Rief et al, 1997;Oesterhelt et al, 2000). AFM has also been used for manipulation of biological material (Fotiadis et al, 2002;Thalhammer et al, 1997). High nanometer resolution, simple sample preparation (no need for vacuum), the ability to measure forces between 10 -4 N and 10 -12 N and possibility of the »in situ« study in dry or in liquid environment are the most straightforward advantages of AFM.…”

Section: Introduction To Use Of Atomic Force Microscopy In Biochemistrymentioning

confidence: 99%

Protein Interactions on Phospholipid Bilayer, Studied by AFM Under Physiological Conditions

Irman¹,

Škarabot²,

Muševič³

et al. 2012

Atomic Force Microscopy Investigations Into Biology - From Cell to Protein

View full text Add to dashboard Cite

“…The stabilization and the positioning of the instrument of future possibilities. For example, Thalhammer et al (1997) used an AFM tip as nano-scalpel, which may be adapted to manipulate cartilage tissue. Moreover, Hug et al (2005) presented a hollow cantilever probe suited for administering small amounts of drugs to a cartilage defect site.…”

Section: Introductionmentioning

confidence: 99%

The measurement of biomechanical properties of porcine articular cartilage using atomic force microscopy

Imer

Akiyama

Rooij

et al. 2009

Arch. Histol. Cytol.

View full text Add to dashboard Cite

relative to the surface under investigation were performed by means of eight inflatable balloons. An integrated threedimensional, piezoelectric scanner allowed raster scanning and probing of a small area of cartilage around the point of insertion. An AFM probe with an integrated deflection sensor was mounted at the distal end of the instrument. Using this instrument, several measurements were performed on agarose gel and on porcine cartilage samples. The load-displacement curves obtained were analyzed and the dynamic elastic moduli E * were calculated. A good correlation between these values and those published in the scientific literature was found. Therefore, we concluded that the SFA can provide quantitative measurements to detect early pathological changes in OA.

show abstract

The Atomic Force Microscope as a New Microdissecting Tool for the Generation of Genetic Probes

Cited by 99 publications

References 21 publications

Atomic Force Microscopy in Cytogenetics

Atomic Force Microscopy in Cytogenetics

Protein Interactions on Phospholipid Bilayer, Studied by AFM Under Physiological Conditions

The measurement of biomechanical properties of porcine articular cartilage using atomic force microscopy

Contact Info

Product

Resources

About