The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis

Abstract

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Association of PNPLA3 (rs738409) & TM6SF2 (rs58542926) and ATG16L1 (rs2241880) genetic variants with susceptibility to hepatocellular carcinoma in a group of Egyptian patients with HCV-induced liver cirrhosis

“…Moreover, our findings proved that GG genotype carriers are 3.2 times riskier to progress to cirrhosis than those carrying the AA genotype while AG genotype carriers are 6.4 times more prone to this risk and that those harboring the G allele are 2 times more prone to progression to liver cirrhosis than individuals with C allele. This is concordant with [ 47 ] study which reported that the ATG16L1 G allele was more prevalent in HCC patients when compared to controls (P = 0.022). G allele carriers were 1.76 folds at more risk to develop HCC (ORs = 1.76, 95% CI: 1.07–2.88).…”