The associations of life quality, depression, and cognitive impairment with mortality in older adults with COVID-19: a prospective, observational study

Bayrak, Muharrem; Çadırcı, Kenan

doi:10.1080/17843286.2021.1916687

Cited by 10 publications

(7 citation statements)

References 29 publications

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“…In our study, depression in the participants who had recovered from COVID-19 was associated with a higher risk of mortality; pre-COVID-19 depression was a risk factor for COVID-19-related mortality. Our results are consistent with the results of a study conducted in a smaller cohort of younger older adults (24). These results substantiate the need for early prevention and screening for cognitive dysfunctions and monitoring cognitive functioning and mood in older adults.…”

Section: Discussionsupporting

confidence: 91%

Mortality and survival in nonagenarians during the COVID-19 pandemic: Unstable equilibrium of aging

Kashtanova

Erema²,

Gusakova³

et al. 2023

Front. Med.

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IntroductionAging puts the human body under an immense stress and makes it extremely susceptible to many diseases, often leading to poor outcomes and even death. Long-living individuals represent a unique group of people who withstood the stress of time and offer an abundance of information on the body’s ability to endure the pressure of aging. In this study, we sought to identify predictors of overall one-year mortality in 1641 long-living individuals. Additionally, we analyzed risk factors for COVID-19-related morality, since statistics demonstrated an extreme vulnerability of older adults.MethodsWe conducted a two-stage evaluation, including a comprehensive geriatric assessment for major aging-associated: frailty, cognitive impairment, frontal lobe dysfunction, chronic pain, anxiety, risk of falls, sensory deficit, depression, sarcopenia, risk of malnutrition, fecal and urinary incontinence, dependence in Activities of Daily Living, dependence in Instrumental Activities of Daily Living, polypragmasia, and orthostatic hypotension; extensive blood testing, a survey, and a one-year follow-up interview.ResultsThe most reliable predictors of overall mortality were cognitive impairment, malnutrition, frailty, aging-associated diseases and blood markers indicating malnutrition-induced metabolic dysfunctions (decreased levels of protein fractions, iron, 25-hydroxyvitamin D, and HDL), and aging biomarkers, such as IGF-1 and N-terminal pro b-type natriuretic peptide. In post-COVID 19 participants, the most significant mortality predictors among geriatric syndromes were depression, frontal lobe dysfunction and frailty, and similar to overall mortality blood biomarkers - 25-hydroxyvitamin D, IGF-1, HDL as well as high white blood cell, neutrophils counts and proinflammatory markers. Based on the results, we built a predictive model of overall mortality in the long-living individuals with f-score=0.76.ConclusionThe most sensitive and reliable predictors of mortality were modifiable. This is another evidence of the critical importance of proper geriatric care and support for individuals in their “golden years”. These results could facilitate geriatric institutions in their pursuit for providing improved care and could aid physicians in detecting early signs of potentially deadly outcomes. Additionally, our findings could be used in developing day-to-day care guidelines, which would greatly improve prevention statistics.

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Section: Discussionsupporting

confidence: 91%

Mortality and survival in nonagenarians during the COVID-19 pandemic: Unstable equilibrium of aging

Kashtanova

Erema²,

Gusakova³

et al. 2023

Front. Med.

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“…The relationship between polypharmacy and increased mortality has also been investigated in some studies. According to the results of 6 studies [ 19 , 20 , 28 , 33 – 35 ], with increasing polypharmacy in the selected samples, mortality due to COVID-19 also increases, which is statistically significant. However, in 2 other studies [ 26 , 30 ], it was stated that the increase in medications used did not have a significant effect on the increase in mortality caused by COVID-19.…”

Section: Resultsmentioning

confidence: 99%

Global prevalence of polypharmacy among the COVID-19 patients: a comprehensive systematic review and meta-analysis of observational studies

et al. 2022

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Background Polypharmacy has traditionally been defined in various texts as the use of 5 or more chronic drugs, the use of inappropriate drugs, or drugs that are not clinically authorized. The aim of this study was to evaluate the prevalence of polypharmacy among the COVID-19 patients, and the side effects, by systematic review and meta-analysis. Methods This study was performed by systematic review method and in accordance with PRISMA 2020 criteria. The protocol in this work is registered in PROSPERO (CRD42021281552). Particular databases and repositories have been searched to identify and select relevant studies. The quality of articles was assessed based on the Newcastle–Ottawa Scale checklist. Heterogeneity of the studies was measured using the I2 test. Results The results of meta-analysis showed that the prevalence of polypharmacy in 14 studies with a sample size of 189,870 patients with COVID-19 is 34.6% (95% CI: 29.6–40). Studies have shown that polypharmacy is associated with side effects, increased morbidity and mortality among patients with COVID-19. The results of meta-regression analysis reported that with increasing age of COVID-19 patients, the prevalence of polypharmacy increases (p < 0.05). Discussion The most important strength of this study is the updated search to June 2022 and the use of all databases to increase the accuracy and sensitivity of the study. The most important limitation of this study is the lack of proper definition of polypharmacy in some studies and not mentioning the number of drugs used for patients in these studies. Conclusion Polypharmacy is seen in many patients with COVID-19. Since there is no definitive cure for COVID-19, the multiplicity of drugs used to treat this disease can affect the severity of the disease and its side effects as a result of drug interactions. This highlights the importance of controlling and managing prescription drugs for patients with COVID-19.

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“…To further complicate matters, prior studies on the association between mental health and cognitive impairment did not evaluate the independent associations between anxiety, depression, or PTSD. The intersection of cognitive impairment and mental health symptoms are cause for concern among individuals infected with SARS-CoV-2, as both are associated with increased risk of mortality among hospitalized patients ( Bayrak and Çadirci, 2021 ). Given that the presence of psychiatric symptoms (in general) and cognitive impairment can significantly increase risk for deleterious health consequences among individuals with SARS-CoV-2 infection, it is essential to better understand which types of psychiatric symptoms are most strongly associated with cognitive impairment in patients with PASC.…”

Section: Introductionmentioning

confidence: 99%

The unique contribution of depression to cognitive impairment in Post-Acute Sequelae of SARS-CoV-2 infection

Brown¹,

Ballentine²,

Zhu³

et al. 2022

Brain, Behavior, & Immunity - Health

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The associations of life quality, depression, and cognitive impairment with mortality in older adults with COVID-19: a prospective, observational study

Cited by 10 publications

References 29 publications

Mortality and survival in nonagenarians during the COVID-19 pandemic: Unstable equilibrium of aging

Mortality and survival in nonagenarians during the COVID-19 pandemic: Unstable equilibrium of aging

Global prevalence of polypharmacy among the COVID-19 patients: a comprehensive systematic review and meta-analysis of observational studies

The unique contribution of depression to cognitive impairment in Post-Acute Sequelae of SARS-CoV-2 infection

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