The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies

Watts, Eleanor L.; Pérez-Cornago, Aurora; Appleby, Paul N.; Albanês, Demetrius; Ardanaz, Eva; Bueno-de-Mesquita, H. Bas; Chan, June M.; Chen, Chu; Chubb, S. A. Paul; Cook, Michael B.; Deschasaux, Mélanie; Donovan, Jenny; English, Dallas R.; Flicker, Leon; Freedman, Neal D.; Galán, Pilar; Giles, Graham G.; Giovannucci, Edward; Gunter, Marc J.; Habel, Laurel A.; Häggström, Christel; Haiman, Christopher A.; Hamdy, Freddie C.; Herçberg, Serge; Holly, Jeff M.P.; Huang, Jiaqi; Huang, Wen Yi; Kaaks, Rudolf; Kubo, Toshikazu; Lane, J A; Layne, Tracy M.; Marchand, Loı̈c Le; Martin, Richard M.; Metter, E. Jeffrey; Mikami, Kōichi; Milne, Roger L.; Morris, Howard A.; Mucci, Lorelei A.; Neal, David E.; Neuhouser, Marian L.; Oliver, Steven; Overvad, Kim; Ozasa, Kotaro; Pala, Valeria; Pernar, Claire H.; Pollak, Michael; Rowlands, M.-A.; Schaefer, Catherine; Schenk, Jeannette M.; Stattin, Pär; Tamakoshi, Akiko; Thysell, Elin; Touvier, Mathilde; Trichopoulou, Antonia; Tsilidis, Konstantinos K.; Eeden, Stephen K. Van Den; Weinstein, Stephanie J.; Wilkens, Lynne R.; Yeap, Bu B.; Key, Timothy J.; Allen, Naomi E.; Travis, Ruth C.

doi:10.1002/ijc.32276

Cited by 18 publications

(19 citation statements)

References 56 publications

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“…In line with previous studies [40,43], participants consuming the highest amount of alcohol (!40 g/day) had lower concentrations of IGF-I. This may be due to ethanol toxicity, which impairs the hepatic synthesis of IGF-I [44].…”

Section: Fibre and Starch From Wholegrainssupporting

confidence: 88%

Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients

et al. 2021

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Background & aims: Circulating insulin-like growth factor-I (IGF-I) is associated with the risk of several cancers. Dietary protein intake, particularly dairy protein, may increase circulating IGF-I; however, associations with different protein sources, other macronutrients, and fibre are inconclusive. Aim: To investigate the associations between intake of protein, macronutrients and their sources, fibre, and alcohol with serum IGF-I concentrations. Methods: A total of 11,815 participants from UK Biobank who completed !4 24-h dietary assessments and had serum IGF-I concentrations measured at baseline were included. Multivariable linear regression was used to assess the crossesectional associations of macronutrient and fibre intake with circulating IGF-I concentrations. Results: Circulating IGF-I concentrations were positively associated with intake of total protein (per 2.5% higher energy intake: 0.56 nmol/L (95% confidence interval: 0.47, 0.66)), milk protein: 1.20 nmol/L (0.90, 1.51), and yogurt protein: 1.33 nmol/L (0.79, 1.86), but not with cheese protein: À0.07 nmol/L (À0.40, 0.25). IGF-I concentrations were also positively associated with intake of fibre (per 5 g/day higher intake: 0.46 nmol/L (0.35, 0.57)) and starch from wholegrains (Q5 vs. Q1: 1.08 nmol/L (0.77, 1.39)), and inversely associated with alcohol consumption (>40 g/day vs < 1 g/day: À1.36 nmol/L (À1.00, À1.71)). Conclusions: These results show differing associations with IGF-I concentrations depending on the source of dairy protein, with positive associations with milk and yogurt protein but no association with cheese protein. The positive association of fibre and starch from wholegrains with IGF-I warrants further investigation.

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Section: Fibre and Starch From Wholegrainssupporting

confidence: 88%

Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients

et al. 2021

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“…Whilst we found no significant effect of the supplementation of micronutrients on circulating sex hormones and IGF-1, the scale of effects for the few studies that included IGF-1 ranged between mean differences for vitamin D of −0.53 nmol/L (95% CI: −1.58, 0.52), for multi-nutrients of 0.60 nmol/L (95% CI −1.12 to 2.33) and carotenoids of −1.32 nmol/L (95% CI −2.76 to 0.11). This compares with the difference for IGF-1 between age groups 50-54 years to 70-74 years of −3.4 nmol/L [146,147]. Although the effect sizes found with micronutrients and IGF-1 in our analysis were non-significant, and smaller than with age, these differences may have potential importance if found to be significant in future well-designed trials.…”

Section: Limitations Of the Available Datasupporting

confidence: 42%

“…Additionally, extraction of hormones should be performed using mass spectrometry, and SHBG should be measured to account for changes to free oestrogen and testosterone that may occur during the intervention. Other known lifestyle factors that affect circulating sex hormones and IGF-1, such as smoking habit and BMI should also be recorded [146,147]. An optimal follow-up time has yet to be elucidated but we would recommend a minimum of 6 months, and that endocrine and nutritional measurements be taken at 3 month intervals until the study is complete.…”

Section: Recommendations For Future Studiesmentioning

confidence: 99%

Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis

et al. 2020

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Observational research suggests that micronutrients may be protective for sarcopenia, a key health issue during ageing, potentially via effects on hormone synthesis and metabolism. We aimed to carry out a systematic review of RCTs investigating effects of increasing dietary or supplemental micronutrient intake on sex hormones and IGF-1 in individuals aged 45 years or older. We searched MEDLINE, EMBASE and Cochrane databases for RCTs reporting the effects of different micronutrients (vitamins A, C, D, or E; carotenoids; iron; copper; zinc; magnesium; selenium; and potassium) on sex hormones or IGF-1. Of the 26 RCTs identified, nine examined effects of vitamin D, nine of multi-nutrients, four of carotenoids, two of selenium, one of zinc, and one of vitamin E. For IGF-1 increasing vitamin D (MD: −0.53 nmol/L, 95% CI: −1.58, 0.52), multi-nutrients (MD: 0.60 nmol/L, 95% CI −1.12 to 2.33) and carotenoids (MD −1.32 nmol/L; 95% CI −2.76 to 0.11) had no significant effect on circulating concentrations. No significant effects on sex hormones of other micronutrients were found, but data were very limited. All trials had significant methodological limitations making effects of micronutrient supplementation on sex hormones unclear. Further high quality RCTs with physiological doses of micronutrients in people with low baseline intakes or circulating concentrations, using robust methodology, are required to assess effects of supplementation adequately.

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“…Another important link between height and cancer risk is the level of various hormones responsible for being tall. In particular, cancer incidence is promoted by high levels of insulin-like growth factors (IGF) and growth hormones (GH) [ 84 , 85 , 86 ] that naturally occur in tall people.…”

Section: Height As a Risk Factor For Gbm Incidencementioning

confidence: 99%

Epidemiology of Anthropometric Factors in Glioblastoma Multiforme—Literature Review

et al. 2021

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Although glioblastoma multiforme (GBM) is a widely researched cancer of the central nervous system, we still do not know its full pathophysiological mechanism and we still lack effective treatment methods as the current combination of surgery, radiotherapy, and chemotherapy does not bring about satisfactory results. The median survival time for GBM patients is only about 15 months. In this paper, we present the epidemiology of central nervous system (CNS) tumors and review the epidemiological data on GBM regarding gender, age, weight, height, and tumor location. The data indicate the possible influence of some anthropometric factors on the occurrence of GBM, especially in those who are male, elderly, overweight, and/or are taller. However, this review of single and small-size epidemiological studies should not be treated as definitive due to differences in the survey methods used. Detailed epidemiological registers could help identify the main at-risk groups which could then be used as homogenous study groups in research worldwide. Such research, with less distortion from various factors, could help identify the pathomechanisms that lead to the development of GBM.

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The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies

Cited by 18 publications

References 56 publications

Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients

Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients

Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis

Epidemiology of Anthropometric Factors in Glioblastoma Multiforme—Literature Review

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