The associations between triglyceride to high‐density lipoprotein cholesterol ratios and the risks of gestational diabetes mellitus and large‐for‐gestational‐age infant

Wang, Dongyu; Xu, Shuqia; Chen, Haitian; Zhong, Lieqiang; Wang, Zilian

doi:10.1111/cen.12742

Cited by 48 publications

(59 citation statements)

References 35 publications

(43 reference statements)

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“…Our findings showed that TG and TG/HDL‐C ratios measured at the time of 24‐28 weeks were significantly increased in GDM, macrosomia, and fetal distress in uterus, compared to healthy pregnant women, which is consistent with other studies. Multivariable logistic regression analysis showed that TG was independently and significantly associated with the odds of GDM, while TG/HDL‐C was independently and significantly associated with the odds of macrosomia and fetal distress in the uterus, which is a different phenomenon reported in other reports …”

Section: Discussionsupporting

confidence: 88%

“…The TG/HDL‐C ratio has been demonstrated to be a valuable index for identifying pregnant women with low risk of GDM before 24 weeks of gestation . TG/HDL‐C ratios measured and calculated at the time of 24‐28 weeks were independently and significantly associated with the odds of GDM …”

Section: Discussionmentioning

confidence: 99%

“…Although maternal circulating TG do not directly cross the placenta, the presence of lipoprotein receptors, fatty acid–binding proteins, and different lipase activities in the placenta allows the efficient transfer of maternal fatty acids to the fetus . Recent studies have reported highly significant positive correlations between fasting maternal TG levels at late gestation and birthweight in both non‐diabetic pregnancies and well‐controlled GDM pregnancies .…”

Section: Discussionmentioning

confidence: 99%

“…Middle trimester pregnancy BMI and blood lipids have not been analyzed for their potential impact upon pregnancy outcomes. Considering that maternal weight gain early in pregnancy is disproportionately due to fat deposition, this could influence subsequent maternal insulin resistance . Furthermore, the rate of development of the fetal‐placental unit is fastest in the second trimester of pregnancy, where blood lipid levels increase greatly.…”

Section: Introductionmentioning

confidence: 99%

“…Considering that maternal weight gain early in pregnancy is disproportionately due to fat deposition, this could influence subsequent maternal insulin resistance. 12 Furthermore, the rate of development of the fetal-placental unit is fastest in the second trimester of pregnancy, where blood lipid levels increase greatly. Therefore, maternal BMI during the second trimester in pregnancy was also included in our study, which has not been reported before.…”

mentioning

confidence: 99%

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Epidemiological analysis of maternal lipid levels during the second trimester in pregnancy and the risk of adverse pregnancy outcome adjusted by pregnancy BMI

Yue

Ying

2018

Clinical Laboratory Analysis

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Epidemiological analysis of maternal lipid levels during the second trimester in pregnancy and the risk of adverse pregnancy outcome adjusted by pregnancy BMI

Yue

Ying

2018

Clinical Laboratory Analysis

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Study of triglyceride changes during pregnancy and neonatal birth weight and adverse outcomes

Wei,

Tang,

Xia

et al. 2024

American J Hum Biol

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BackgroundChanges of maternal triglyceride concentrations are closely associated with intrauterine fetal growth and development, but the effect of mid‐ to late‐term triglyceride changes on birth weight is uncertain. This study investigated the association between changes in triglycerides in mid to late in pregnant women gestational age ≥ 35 weeks on neonatal birth weight and adverse outcomes.MethodsThis cohort study was based on 931 pregnant women with a singleton delivery at gestational age ≥ 35 weeks from January 1, 2022 to December 31, 2022 at Nanjing Lishui People's Hospital (NJLSPH) in China, with all maternal triglyceride concentrations measured at mid‐term and late‐term before delivery. The primary outcomes were neonatal birth weight and the risk of macrosomia.ResultsLate term triglyceride levels were positively associated with birth weight (β = 126.40, 95% CI: 61.95, 190.84, p < .001) and risk of macrosomia (OR = 2.11, 95% CI: 1.12, 3.98, p = .022). Late mid‐term triglyceride was positively associated with birth weight (β = 27.58, 95% CI: 9.67, 45.50, p = .003), and no correlation with risk of macrosomia (OR = 1.12, 95% CI: 0.95, 1.31, p = .178). Mid‐term triglyceride was not associated with birth weight (β = 45.79, 95% CI: −28.73, 120.30, p = .229) and risk of macrosomia (OR = 1.83, 95% CI: 0.89, 3.78, p = .101).ConclusionLate triglyceride levels were associated with birth weight and risk of macrosomia, while late to mid‐term triglyceride were associated with birth weight but not with risk of macrosomia. This suggests that maternal triglyceride changes may affect fetal growth and development, and more studies focusing on the effects of gestational triglyceride profiles are warranted.

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Elevated serum triglyceride levels at first prenatal visit is associated with the development of gestational diabetes mellitus

Niu

et al. 2021

Diabetes Metabolism Res

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Aims: While several studies have indicated that maternal serum lipid profiles are associated with the development of gestational diabetes mellitus (GDM), the results have been inconsistent. This study aimed to explore the relationship between maternal lipids profiles at first prenatal visit and GDM and determine the optimal cut-off values of possible trimester-specific variables in predicting GDM. Materials and Methods:Clinical data of women with singleton pregnancies who delivered in Xinhua Hospital between January 2016 and January 2017 were collected from electronic databases. Multivariate logistic regression was used to determine the potential risk factors of GDM (specific to the trimester at first prenatal visit), including age, body mass index (BMI), and serum lipid profile and fasting plasma glucose (FPG) levels. The receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off values of significant variables.Results: Among the 2191 pregnant women included, 315 (14.38%) were diagnosed with GDM. Of these, 880 (40.16%) had their first prenatal visit before 14 gestational weeks. Univariate and multivariate analyses showed that both FPG and triglyceride (TG) levels in the first and second trimesters were associated with a high risk of GDM (p < 0.05). The ROC curve showed that serum TG levels >1.235 mmol/ L and >1.525 mmol/L in the first and second trimesters, respectively, were significantly associated with the development of GDM (p < 0.05).

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The associations between triglyceride to high‐density lipoprotein cholesterol ratios and the risks of gestational diabetes mellitus and large‐for‐gestational‐age infant

Abstract: TG/HDL-C ratios in combination with HbA1c and prepregnancy BMI can be good markers to predict the risks of GDM and delivering LGA infant.

Cited by 48 publications

References 35 publications

Epidemiological analysis of maternal lipid levels during the second trimester in pregnancy and the risk of adverse pregnancy outcome adjusted by pregnancy BMI

Epidemiological analysis of maternal lipid levels during the second trimester in pregnancy and the risk of adverse pregnancy outcome adjusted by pregnancy BMI

Study of triglyceride changes during pregnancy and neonatal birth weight and adverse outcomes

Elevated serum triglyceride levels at first prenatal visit is associated with the development of gestational diabetes mellitus

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