The Associations between Interleukin-17 Single Nucleotide Polymorphism and Colorectal Cancer Susceptibility: A Systematic Review and Meta-Analysis

Abstract

Backgrounds: Numerous of case-control studies have reported the associations between Interleukin-17 (IL-17) polymorphisms and colorectal cancer, however, the results were inconsistent. The aim of this meta-analysis was to further clarify the effects of IL-17 polymorphisms on colorectal cancer susceptibility.Materials and method: Relevant Studies were extracted from electronic databases of Pubmed, Embase, Web of science, China National Knowledge Infrastructure (CNKI) and Chinese Biomedical Literature Database (CMB) up to April 2021. The Odds ratio and 95% confidence interval were conducted to estimate the strength of the associations and the Stata 13.0 software was used to perform the meta-analysis.Results: Ten articles including 2599 cases and 2845 controls were enrolled in our research after strictly literature screening. Highly significant associations between IL-17A rs2275913 polymorphism and increased colorectal cancer susceptibility were observed in all the five gene models (allelic, dominant, recessive, homozygous and heterozygous models), subgroup analysis based on ethnicity revealed that these associations existed not only in Asia population, but also in Caucasian population. However, the results showed no significantly elevated colorectal cancer risk correlated to IL-17F rs763780 polymorphism and a slightly lower colorectal cancer susceptibility for Caucasian population was discovered in the recessive and homozygous models of this mutation.Conclusion: IL-17A rs2275913 polymorphism may be an independent risk factor contributed to colorectal cancer susceptibility, while IL-17F rs763780 polymorphism displayed a possible decreased susceptibility to colorectal cancer. Future studies with large-scale samples were warranted to identify these associations.

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

“…IL17A polymorphism has also been reported as a risk factor for lupus nephritis [41]. Moreover, the IL17A gene variant has been linked to an increased risk of colorectal cancer in Asians and Caucasians [86,87], osteoarthritis in Caucasians [88], IgA nephropathy in Chinese Hans [89], polycystic ovarian syndrome in Chinese people [90], diabetic nephropathy in Iranians [91], diverse cancer in Asians [92], preeclampsia in Chinese people [93], and rheumatoid arthritis in Europeans [94]. However, IL17A polymorphism has been reported to show no association with many diseases, such as European and Asian psoriasis [95], Egyptian multiple myeloma [96], and Polish periodontitis [97].…”