The Associations Between IL-18 Serum Levels and the Prevalence of Metabolic Syndrome in Polish Men Over the Age of 40 According to Other Selected Inflammatory Indices and Androgens: Comparison of NCEP with IDF Criteria

Abstract

Inflammatory parameters were better than a deficit of androgens in identifying men suffering from MS. However, the best correlation with the number of MS components was revealed by IL-18 plasma levels.

Leucocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance

“…We have also previously demonstrated that even when matched for IR, women with PCOS had greater VLDL levels, small dense LDL and reduced high‐molecular‐weight adiponectin . There is some evidence that hyperandrogenaemia contributes to a pro‐inflammatory state, but this is not consistent . There is also evidence that elevated triglyceride and low HDL levels are associated with increased WCC and in vitro models have demonstrated triglyceride mediated activation of neutrophils .…”

“…20,21 There is some evidence that hyperandrogenaemia contributes to a pro-inflammatory state, but this is not consistent. 17,18 There is also evidence that elevated triglyceride and low HDL levels are associated with increased WCC and in vitro models have demonstrated triglyceride mediated activation of neutrophils. 33 Thus, it is plausible that hyperandrogenaemia, central adiposity and dyslipidaemia individually or in combination might explain leucocytosis.…”

“…It has been postulated that IR underlies chronic inflammation in PCOS, but this has not been clearly demonstrated. Because there are also pro‐inflammatory effects of hyperandrogenaemia, it is possible that the inflammatory state in PCOS is greater than that resulting from IR alone.…”

White blood cell differential counts in patients with polycystic ovary syndrome: a pilot study on Chinese women

“…There are several pieces of evidence that hyperandrogenism contributes to a pro-inflammatory state, but they are not consistent [16,17]. The expression pattern of androgen receptors, which have been documented in lymphoid and nonlymphoid cells of thymus and bone marrow but not in mature peripheral lymphocytes, suggests that androgen plays an important part in the development and activation of lymphocytes [18].…”

<p>Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome?</p>

“…SHBG also affects inflammatory pathways by interacting with lymphocytes via membrane receptors 53. CRP shows no direct association with androgens, both gonadal and adrenal, implying that SHBG changes might happen prior to changes in androgens, suggesting even more the important role of early SHBG imbalance in MS. Our current and earlier research suggests that the consequence of chronic inflammation in patients with metabolic syndrome might be more complicated, affecting hormones and their carrier proteins as well 54…”