The associations between dietary fibers intake and systemic immune and inflammatory biomarkers, a multi-cycle study of NHANES 2015–2020

Abstract

BackgroundIn recent years, there has been considerable growth in abnormal inflammatory reactions and immune system dysfunction, which are implicated in chronic inflammatory illnesses and a variety of other conditions. Dietary fibers have emerged as potential regulators of the human immune and inflammatory response. Therefore, this study aims to investigate the associations between dietary fibers intake and systemic immune and inflammatory biomarkers.MethodsThis cross-sectional study used data from the National Health and Nutrition Examination Survey (2015–2020). Dietary fibers intake was defined as the mean of two 24-h dietary recall interviews. The systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), red blood cell distribution width-to-albumin ratio (RA), ferritin, high-sensitivity C-reactive protein (hs-CRP), and white blood cell (WBC) count were measured to evaluate systemic immune and inflammatory states of the body. The statistical software packages R and EmpowerStats were used to examine the associations between dietary fibers intake and systemic immune and inflammatory biomarkers.ResultsOverall, 14,392 participants were included in this study. After adjusting for age, gender, race, family monthly poverty level index, alcohol consumption, smoking status, vigorous recreational activity, body mass index, hyperlipidemia, hypertension, diabetes, and dietary inflammatory index, dietary fibers intake was inversely associated with SII (β = −2.19885, 95% CI: −3.21476 to −1.18294, p = 0.000248), SIRI (β = −0.00642, 95% CI: −0.01021 to −0.00263, p = 0.001738), NLR (β = −0.00803, 95% CI: −0.01179 to −0.00427, p = 0.000284), RA (β = −0.00266, 95% CI: −0.00401 to −0.00131, p = 0.000644), ferritin (β = −0.73086, 95% CI: −1.31385 to −0.14787, p = 0.020716), hs-CRP (β = −0.04629, 95% CI: −0.0743 to −0.01829, p = 0.002119), WBC (β = −0.01624, 95% CI: −0.02685 to −0.00563, p = 0.004066), neutrophils (β = −0.01346, 95% CI: −0.01929 to −0.00764, p = 0.000064). An inverse association between dietary fibers and PLR was observed in the middle (β = −3.11979, 95% CI: −5.74119 to −0.4984, p = 0.028014) and the highest tertile (β = −4.48801, 95% CI: −7.92369 to −1.05234, p = 0.016881) and the trend test (βtrend = −2.2626, 95% CI: −3.9648 to −0.5604, Ptrend = 0.0150). The observed associations between dietary fibers intake and SII, SIRI, NLR, RA, ferritin, hs-CRP, WBC, and neutrophils remained robust and consistent in the sensitivity analysis. No significant interaction by race was found.ConclusionDietary fibers intake is associated with the improvement of the parameters of the immune response and inflammatory biomarkers, supporting recommendations to increase dietary fibers intake for enhanced immune health.

Association between dietary inflammatory index and fecal incontinence in American adults: a cross-sectional study from NHANES 2005–2010

“…Indeed, we reviewed Menees SB's research and interestingly found that the overall inflammatory effect score of carbohydrates (FLD) was only 0.097 while fibers (psyllium) was even −0.663 (anti-inflammatory effect), much lower than fat (0.298), cholesterol (0.110), saturated fatty acids (0.373), and other daily dietary components ( 14 ). In addition, fiber intake has been demonstrated to be associated with improved parameters of the inflammatory response ( 35 ), and high consumption of fruits, vegetables, whole grains, and healthy fats has been implicated in a reduced inflammatory response ( 36 ). This may also explain why a low LFD diet with fiber intake helps improve FI from a dietary inflammatory perspective.…”

Independent and combined effects of smoking, drinking and depression on periodontal disease

“…The sociodemographic variables included in this study were age (in years), gender (male, female), race/ethnicity (non-Hispanic white, non-Hispanic black, non-Hispanic Asian, Mexican Americans, and other race), education level (less than 9th Grade, 9-11th Grade, high school grade/ General Education Development or Diploma or equivalent, some college or Associate of Arts Degree, college graduate or above, missing), marital status (married/living with partner, widowed/divorced/separated, missing), history of diabetes (no, yes, missing), and family monthly poverty level (≤ 1.30, 1.30–1.85, 1.85–5, > 5, missing) [ 23 , 24 ], as per the poverty guidelines outlined by the U.S. Department of Health and Human Services (HHS) and the recommendations provided by the National Health and Nutrition Examination Survey (NHANES) [ 25 ]. Body mass index (BMI) was classified as low weight (< 18.5 kg/m 2 ), normal weight (18.5 to 25 kg/m 2 ), overweight (25 to 30 kg/m 2 ) and obesity (≥ 30 kg/m 2 ) [ 26 ].…”

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