The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study

Hilton, Catriona; Vasan, Senthil K.; Neville, Matt J.; Christodoulides, Constantinos; Karpe, Fredrik

doi:10.1080/17446651.2022.2008238

Cited by 14 publications

(9 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, ASMI showed positive correlations with both BMD and TBS. The apparent favorable impact of LM on LS BMD is consistent with previous results shown in both healthy individuals [61] and IBD patients [14]. In a Manitoba IBD cohort study, LM was the strongest determinant of BMD and its variation was associated with changes in bone density [62].…”

Section: Discussionsupporting

confidence: 89%

Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease

Soare

Sîrbu

Popa

et al. 2022

Life

View full text Add to dashboard Cite

Background: Bone impairment of multifactorial etiology is a common feature in inflammatory bowel disease (IBD). Body composition parameters, which might be selectively modified in these patients, are important determinants of bone strength. Our aim was to investigate the relationship between components of body composition and bone parameters in IBD patients. Methods: This is a cross-sectional, retrospective study including 80 IBD patients (43 women, 37 men). Lumbar spine (LS), femoral neck (FN) and whole body DXA scans were performed to analyze regional bone mineral density (BMD), as well as body composition, including appendicular skeletal muscle mass index (ASMI), total and visceral fat mass (VAT). Trabecular bone score (TBS) was assessed using iNsight Software. Results: Twenty (25%) IBD patients had inadequate LS-BMD z scores (<=−2DS). Lean mass (LM) was a significant determinant of LS-BMD, after adjusting for age, gender, BMI and fat mass (p < 0.01), while fat mass% remained associated with FN-BMD (p < 0.01). TBS correlated positively with BMI (r = 0.24, p < 0.05), LS-BMD (r = 0.56, p < 0.001), ASMI (r = 0.34, p < 0.001) and negatively with VAT/total fat% (r = −0.27, p < 0.05). Multivariate analysis showed that ASMI, LS-BMD (positively) and VAT/total fat% (negatively) were independently associated with TBS. Conclusions: In IBD patients, skeletal muscle mass and fat percentage and distribution are important factors associated with bone health.

show abstract

Section: Discussionsupporting

confidence: 89%

Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease

Soare

Sîrbu

Popa

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…Whereas, in the elderly women with osteoporosis, fat mass presented a positive correlation with total body BMD [40]. When taking the fat distribution into consideration, central fat accumulation (increased android and visceral fat in men and increased visceral fat in women) were associated with lower BMD among 4,900 healthy individuals aged 30-50 years old from Oxford BioBank [41]. Likewise, android fat and visceral fat presented signi cant inverse associations with bone quality assessed by trabecular bone score in healthy Chinese men [42].…”

Section: Discussionmentioning

confidence: 95%

Gender-Specific Impacts of Thigh Skinfold Thickness and Grip Strength for Predicting Osteoporosis in Type 2 Diabetes

Lee

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Diabetes with co-existing bone fragility or osteoporosis is common in elderly patients, whereas is frequently underestimated. Methods We conducted dual-energy x-ray absorptiometry (DXA) with 7-site skinfold (SF) and dominant hand grip strength measurements among patients with type 2 diabetes (T2DM) to assess their gender-specific associations. A total of 103 patients with T2DM (60 females and 43 males), aged between 50–80 years (median 68.0 years) were enrolled. Results Our results revealed osteoporosis was negatively correlated with grip strength in both genders, negatively correlated with lean mass solely in males and negatively correlated with fat mass (particular the gynoid fat mass and thigh SF thickness) in females. Via performing multivariable stepwise logistic regression, we identified grip strength in both genders and thigh SF thickness in females as predictors for osteoporosis. Receiver operating characteristic curve analysis further disclosed 20.5 mm female thigh skinfold thickness, 18.1 kg female grip strength and 29.0 kg male grip strength as reasonable cutoff levels for predicting osteoporosis in the Taiwanese patients with T2DM. Conclusions Patients with T2DM presented gender-specific associations between osteoporosis, body composition and grip strength. Grip strength and thigh SF thickness might serve as predictors for early detection of osteoporosis in patients with T2DM.

show abstract

“…The primary objective of our research study was to investigate the potential impact of the distribution of FM throughout different regions of the body on the odds of developing DS. In a recent study [ 47 ], it was found that abdominal visceral fat has an inverse relationship with bone density, and in this regard, increasing insulin resistance has been proposed as a mechanism. However, limbs FM was not measured in that study and the participants were non-older adults.…”

Section: Discussionmentioning

confidence: 99%

The association of body composition and fat distribution with dysmobility syndrome in community-dwelling older adults: Bushehr Elderly Health (BEH) program

Khaleghi,

Emamat,

Marzban

et al. 2023

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background and objective Dysmobility Syndrome (DS) is characterized as an accumulation of clinical risk factors for functional disability, such as osteoporosis, sarcopenia, and obesity. Neurological disorders that affect the motor and sensory systems can also contribute to the condition, resulting in gait and muscle strength disturbances, as well as a history of falls and fractures. The study aimed to determine the association between fat distribution in different body areas and the odds of older adults developing DS, as there is still uncertainty about the accumulation of fat in which area is most closely linked to the condition. Methods This cross-sectional study was conducted according to the data from the second phase of the Bushehr Elderly Health Cohort (BEH). Dysmobility Syndrome was defined based on the co-occurrence of at least three outcomes of its criteria. Body composition was measured using dual-energy X-ray absorptiometry (DXA) and anthropometric studies. For evaluating the relationship, multivariate logistic regression and adjusted univariate linear regression were used. Results Of 2,359 who were recruited in the study, 1,277 participants (54.13%) had DS. According to the final logistic regression model in the limb region, FM and FM to FFM ratios were significantly associated with DS [OR (95%CI) = 1.04 (1.02 to 1.05), and 3.42 (1.95 to 5.99), respectively]. Also, In the trunk region, the FM and FM to FFM ratio were significantly related to the odds of DS, although this relationship was weaker than in the limbs region [OR (95%CI) = 1.02 (1.00 to 1.03), and 2.45 (1.36 to 4.39), respectively]. Conclusion Our findings indicate that a higher regional and whole-body amount of fat mass rather than fat-free mass is closely linked to an increased risk of DS, particularly in the elderly population. Notably, higher fat mass in the limbs (especially in the legs) is associated with greater odds of DS, while a higher android-to-gynoid fat mass ratio is associated with lower DS risk. Screening fat mass distribution in older individuals can be a valuable strategy for promptly diagnosing DS, implementing interventions to prevent disabilities, and improving their quality of life.

show abstract

The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study

Cited by 14 publications

References 68 publications

Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease

Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease

Gender-Specific Impacts of Thigh Skinfold Thickness and Grip Strength for Predicting Osteoporosis in Type 2 Diabetes

The association of body composition and fat distribution with dysmobility syndrome in community-dwelling older adults: Bushehr Elderly Health (BEH) program

Contact Info

Product

Resources

About