The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study

Hilton, Catriona; Vasan, Senthil K.; Neville, Matt J.; Karpe, Fredrik

doi:10.1530/endoabs.65.op4.4

Cited by 3 publications

(3 citation statements)

References 56 publications

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“…Whereas, in the elderly women with osteoporosis, fat mass presented a positive correlation with total body BMD [40]. When taking the fat distribution into consideration, central fat accumulation (increased android and visceral fat in men and increased visceral fat in women) were associated with lower BMD among 4,900 healthy individuals aged 30-50 years old from Oxford BioBank [41]. Likewise, android fat and visceral fat presented signi cant inverse associations with bone quality assessed by trabecular bone score in healthy Chinese men [42].…”

Section: Discussionmentioning

confidence: 95%

Gender-Specific Impacts of Thigh Skinfold Thickness and Grip Strength for Predicting Osteoporosis in Type 2 Diabetes

Lee

et al. 2023

Preprint

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Background Diabetes with co-existing bone fragility or osteoporosis is common in elderly patients, whereas is frequently underestimated. Methods We conducted dual-energy x-ray absorptiometry (DXA) with 7-site skinfold (SF) and dominant hand grip strength measurements among patients with type 2 diabetes (T2DM) to assess their gender-specific associations. A total of 103 patients with T2DM (60 females and 43 males), aged between 50–80 years (median 68.0 years) were enrolled. Results Our results revealed osteoporosis was negatively correlated with grip strength in both genders, negatively correlated with lean mass solely in males and negatively correlated with fat mass (particular the gynoid fat mass and thigh SF thickness) in females. Via performing multivariable stepwise logistic regression, we identified grip strength in both genders and thigh SF thickness in females as predictors for osteoporosis. Receiver operating characteristic curve analysis further disclosed 20.5 mm female thigh skinfold thickness, 18.1 kg female grip strength and 29.0 kg male grip strength as reasonable cutoff levels for predicting osteoporosis in the Taiwanese patients with T2DM. Conclusions Patients with T2DM presented gender-specific associations between osteoporosis, body composition and grip strength. Grip strength and thigh SF thickness might serve as predictors for early detection of osteoporosis in patients with T2DM.

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Section: Discussionmentioning

confidence: 95%

Gender-Specific Impacts of Thigh Skinfold Thickness and Grip Strength for Predicting Osteoporosis in Type 2 Diabetes

Lee

et al. 2023

Preprint

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“…Conversely, Gilsanz et al used computed tomography to evaluate health young women and reported that visceral and subcutaneous fat have opposite effects on the appendicular skeleton; whereas subcutaneous fat was beneficial to bone structure and strength, visceral fat had negative associations with bone features (26). In addition, a recent study including 4,900 healthy individuals aged 30-50 years old reported that visceral adipose tissue in both men and women was associated with lower aBMD (27). Ng et al assessed central and peripheral vBMD in a cohort of men and women aged 20-97 years (28).…”

Section: Discussionmentioning

confidence: 99%

Fat, adipokines, bone structure and bone regulatory factors associations in obesity

Vilaça

Evans

Gossiel

et al. 2022

European Journal of Endocrinology

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Context: Obese adults (OB; BMI ≥30) have higher bone mineral density (BMD) and more favourable bone microarchitecture than normal weight adults (NW; BMI 18.5-24.9). Objective: To identify which fat compartments have the strongest association with bone density and bone turnover and whether biochemical factors (adipokines, hormones and bone regulators) are likely to be important mediators of the effect of obesity on bone. Design: Cross-sectional, observational, matched case-control study. Setting: Participants were recruited from the local community Participants: Two hundred healthy men and women aged 25-40 or 55-75 were recruited in individually-matched OB and NW pairs. Body composition, BMD and bone microarchitecture were determined by dual energy X-ray absorptiometry (DXA), computed tomography (CT) and high resolution peripheral computed tomography (HR-pQCT). Bone turnover and potential regulators such as C-terminal cross-linking telopeptide (CTX), type 1 procollagen N-terminal peptide (PINP), sclerostin, periostin, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), insulin like growth factor 1 (IGF-1), adiponectin, leptin and insulin were assessed. Main outcome: Planned exploratory analysis of the relationships between fat compartments, areal and volumetric BMD, bone microarchitecture, bone turnover markers and bone regulators. Results: Compared with NW, OB had lower CTX, PINP, adiponectin, IGF-1, and 25OHD and higher leptin, PTH and insulin (all p<0.05). CTX and subcutaneous adipose tissue (SAT) were the bone marker and fat compartment most consistently associated with areal and volumetric BMD. In regression models, SAT was negatively associated with CTX (p<0.001). When leptin was added to the model, SAT was no longer associated with CTX, but leptin (p<0.05) was negatively associated with CTX. Conclusions: SAT is associated with lower bone resorption and properties favourable for bone strength in obesity. Leptin may be an important mediator of the effects of SAT on the skeleton.

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“…In a study including 200 participants, Amy L Evans et al found that obese individuals had higher BMD (including whole body, hip and lumbar spine), thicker and denser bone cortex, and more trabeculae [11]. Even when fat is not considered, there is still a strong positive correlation between total lean body mass and total BMD in both sexes [12]. A bone is always responding to and adjusting to changes in mechanical loads caused by body weight, movement, and gravity [13].…”

Section: Discussionmentioning

confidence: 99%

Gender-related association of osteoporosis and bone mineral density with body fat distribution in the general US population: a case control study

Chen

2022

Preprint

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Background: There have been few population-based studies investigated the association between fat distribution and osteoporosis and the bone mineral density (BMD). Methods: Our survey was based on the data from 2017-2018 National Health and Nutrition Examination Survey (NHANES). A total body dual energy X-ray absorptiometry (DXA) scan was conducted to assess the body composition. Participants were asked whether they had previously received a physician diagnosis of osteoporosis through the survey. To assess the effects of body mass index (BMI) and android: gynoid ratio (AGR) on osteoporosis in male and female, we performed the multivariate logistic regression analysis. Results: A total of 336 male and 329 female subjects participated in the study. In male, BMI was positively correlated with BMD of lumbar spine and lower limbs. And there was no significant interaction between AGR and BMD. There were positive correlations between both BMI and AGR and the BMD of lower limbs in female. And only BMI was positively correlated with lumbar spine BMD. Conclusions: BMI was negatively associated with the risk of osteoporosis in male. For female, such protect was caused by AGR.

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The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study

Cited by 3 publications

References 56 publications

Gender-Specific Impacts of Thigh Skinfold Thickness and Grip Strength for Predicting Osteoporosis in Type 2 Diabetes

Gender-Specific Impacts of Thigh Skinfold Thickness and Grip Strength for Predicting Osteoporosis in Type 2 Diabetes

Fat, adipokines, bone structure and bone regulatory factors associations in obesity

Gender-related association of osteoporosis and bone mineral density with body fat distribution in the general US population: a case control study

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