The Associations Between Alanine Aminotransferase and Other Biochemical Parameters in Lean PCOS

Abstract

To explore the associations of alanine aminotransferase in lean women of polycystic ovary syndrome (PCOS) with other biochemical parameters and the potential risk factors. This is a retrospective cohort study with lean PCOS (n = 91) and healthy controls (n = 45); we reviewed the electrical records and databases of the PCOS patients in our infertility clinic between January 2019 and September 2021; independent t-test, linear correlation analysis, and multiple linear regression were used to explore the associations. Higher levels of luteinizing hormone, total testosterone, thyroid stimulating hormone, platelet count, lymphocyte count, homocysteine, alanine aminotransferase (ALT), and uric acid were identified in lean PCOS patients, while follicle-stimulating hormone level was lower in in lean PCOS as expected (P < 0.05). Of note, the linear correlation showed that BMI, total testosterone, white blood cell count, lymphocyte count, aspartate aminotransferase, and uric acid were positively associated with alanine aminotransferase (r = 0.232, 0.318, 0.218, 0.388, 0.602, 0.353 respectively, P < 0.05). After multiple linear regression was performed, total testosterone and aspartate aminotransferase were independently and positively correlated with alanine aminotransferase in lean PCOS (B = 0.251, 0.605 respectively, P < 0.05). Higher level of ALT was identified in the lean PCOS. BMI, white blood cell count, lymphocyte count, aspartate aminotransferase, uric acid, and total testosterone were positively correlated with ALT in lean PCOS. Total testosterone and aspartate aminotransferase were independently and positively associated with ALT in lean PCOS after multiple linear regression. There might exist a potential risk of afflicting liver impairment for the lean PCOS women in the earlier period. Early examination and intervention might be necessary to prevent or delay the progression of the liver disease as soon as the diagnosis of PCOS.

The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats

“…The results of liver enzymes activities were identical with other study [44], which they indicated a greater activity of ALT in PCOS patients, ascribed mostly to growing prevalence of obesity, hyperandrogenism, insulin resistance, and dyslipidemia associated with PCOS. Nevertheless, association in ALT and PCOS with obese situation had been documented more often compared to overweight PCOS.…”

Association between serum levels of calcium, magnesium, iron and copper and insulin resistance in women with full blown and not-full blown phenotypes of polycystic ovary syndrome

“…There were no differences in blood concentrations of estradiol, FSH, 17-OH progesterone and androstenedione. Higher levels of luteinizing hormone and total testosterone, were also confirmed in another study, but the authors did not take into account the division into phenotypes, but only into normal and excessive body mass [25]. .…”

“…Other authors also point to the occurrence of disturbances in biochemical parameters. However, it is important to remember about other factors influencing the differences in results, such as the body mass of the study group, the presence of fatty liver or the division into phenotypes [25,26].…”

Risk factors for insulin resistance related to polycystic ovarian syndrome in Iranian population

“…There is evidence of high ALT levels in lean PCOS patients 42 . Our study suggests that ALT levels in PCOS may be linked to insulin resistance, irrespective of obesity.…”