The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma

D, Xu; Shen, Han‐Ming; Zhu, Qingsan; Chua, Lay‐Lay; Wang, Qunan; Chia, Sin-Eng; Ong, Choon Nam

doi:10.1016/s1383-5718(02)00274-7

Cited by 179 publications

(134 citation statements)

References 35 publications

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“…Seminal plasma cadmium levels have been reported to be unrelated to semen parameters and fertility status (71)(72)(73)(74), to be positively correlated with semen parameters (75), to increase as sperm concentration is decreased (76,77), and to be inversely related to semen parameters only in those men whose semen parameters are already adversely compromised (44,78,79). Our results showed an inverse correlation of seminal plasma cadmium levels with semen parameters in men from infertile couples (group 1) but not known fertile males (group 2) or volunteers from the general population (group 3).…”

Section: Discussionmentioning

confidence: 99%

Cadmium Concentrations in Blood and Seminal Plasma: Correlations with Sperm Number and Motility in Three Male Populations (Infertility Patients, Artificial Insemination Donors, and Unselected Volunteers)

Benoff

Hauser

Marmar

et al. 2009

Mol Med

134

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To investigate a possible common environmental exposure that may partially explain the observed decrease in human semen quality, we correlated seminal plasma and blood cadmium levels with sperm concentration and sperm motility. We studied three separate human populations: group 1, infertility patients (Long Island, NY, USA); group 2, artificial insemination donors (AID) (Rochester, NY, USA); and group 3, general population volunteers (Rochester, NY, USA). Information about confounding factors was collected by questionnaire. Seminal plasma cadmium did not correlate with blood cadmium (Spearman correlation, n = 91, r = -0.092, P = 0.386, NS). Both blood and seminal plasma cadmium were significantly higher among infertility patients than the other subjects studied (for example, median seminal plasma cadmium was 0.282 μg/L in infertility patients versus 0.091 μg/L in AID and 0.092 μg/L in general population volunteers; Kruskal-Wallis test, P < 0.001). The percentage of motile sperm and sperm concentration correlated inversely with seminal plasma cadmium among the infertility patients (r = -0.201, P < 0.036 and r = -0.189, P < 0.05, respectively), but not in the other two groups. Age (among infertility patients) was the only positive confounder correlating with seminal plasma cadmium. To validate our human findings in an animal model, we chronically exposed adolescent male Wistar rats to low-moderate cadmium in drinking water. Though otherwise healthy, the rats exhibited decreases in epididymal sperm count and sperm motility associated with cadmium dose and time of exposure. Our human and rat study results are consistent with the hypothesis that environmental cadmium exposures may contribute significantly to reduced human male sperm concentration and sperm motility.

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Section: Discussionmentioning

confidence: 99%

Cadmium Concentrations in Blood and Seminal Plasma: Correlations with Sperm Number and Motility in Three Male Populations (Infertility Patients, Artificial Insemination Donors, and Unselected Volunteers)

Benoff

Hauser

Marmar

et al. 2009

Mol Med

134

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“…Some studies have shown that a deficiency in semen antioxidants is associated with sperm DNA damage, whereas, other studies have not observed such a relationship [6,[36][37][38][39]. Similarly, some studies have found that seminal antioxidant activity is reduced in infertile men with high levels of seminal ROS (relative to those with normal levels of ROS) whereas others have not shown this [14,[40][41][42].…”

Section: Semen Antioxidants and Sperm Dna Damagementioning

confidence: 99%

Antioxidants and sperm DNA damage: a clinical perspective

Zini

Gabriel

Baazeem

2009

J Assist Reprod Genet

175

110

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Purpose Infertile men possess substantially more sperm DNA damage than do fertile men, damage that may impact negatively on reproductive outcomes. In this era of assisted reproductive technologies there is mounting concern regarding the safety of utilizing DNA-damaged spermatozoa in this setting. Therefore, it is important to identify strategies that may reduce sperm DNA damage. The purpose of this review is to discuss the rationale for antioxidant therapy in men with sperm DNA damage and to evaluate the data on the efficacy of dietary and in vitro antioxidant preparations on sperm DNA damage. Methods We reviewed the literature on antioxidants and sperm DNA damage. Results To date, the data suggest that dietary antioxidants may be beneficial in reducing sperm DNA damage, particularly, in men with high levels of DNA fragmentation. However, the mechanism of action of dietary antioxidants has not been established and most of the clinical studies are small. A beneficial effect of in vitro antioxidant supplements in protecting sperm DNA from exogenous oxidants has been demonstrated, however, the effect of these antioxidants in protecting sperm from endogenous ROS, gentle sperm processing and cryopreservation has not been established.

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“…By oxidizing SH groups of protamines from epididymal sperm in the presence of hydroperoxides, PHGSH-Px participates in the condensation of chromatin (Godeas et al 1997). A positive correlation exists between seminal plasma selenium and sperm density, sperm number, motility and viability in humans (Xu et al 2003).…”

Section: Antioxidative Defence Systems In Semenmentioning

confidence: 95%

Reactive oxygen species and their influence on stallion semen fertility - a review

Pagl¹,

Aurich²,

Aurich³

2006

PHK

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SummaryLosses in motility and fertilizing ability of stored semen can at least in part be attributed to lipid peroxidation of the sperm plasma membrane. Physiologically, mitochondrial respiration is the main source of reactive oxygen species (ROS). In processed semen, ROS originate from contaminating leucocytes and from spermatozoa with residual cytoplasm. In addition, normal spermatozoa produce ROS as a result of their flagellar activity. At low concentrations, ROS have positive biological effects and regulate physiological sperm functions. Mammalian sperm cell membranes have a specific lipid composition with a high content of polyunsaturated fatty acids, making them particularly susceptible to damage by ROS. Peroxidation increases membrane permeability and decreases metabolic activity of sperm cells. To control the effects of ROS, semen contains antioxidants. Enzymatic antioxidants are glutathione peroxidase, superoxide dismutase and catalase. Antioxidants have been substituted in semen through the diet or by adding antioxidants to semen extender. However, as the loss of sperm motility during cooled-storage is not only an effect of plasma membrane dysfunction but also of mitochondrial membrane dysfunction, addition of antioxidants to semen during cooled-storage may have only limited effects.

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The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma

Cited by 179 publications

References 35 publications

Cadmium Concentrations in Blood and Seminal Plasma: Correlations with Sperm Number and Motility in Three Male Populations (Infertility Patients, Artificial Insemination Donors, and Unselected Volunteers)

Cadmium Concentrations in Blood and Seminal Plasma: Correlations with Sperm Number and Motility in Three Male Populations (Infertility Patients, Artificial Insemination Donors, and Unselected Volunteers)

Antioxidants and sperm DNA damage: a clinical perspective

Reactive oxygen species and their influence on stallion semen fertility - a review

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