The associations among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of paraoxonases in children with attention deficit/hyperactivity disorder

Chang, Chia Huang; Yu, Ching Jung; Du, Jung Chieh; Chiou, Hsien Chih; Hou, Jia‐Woei; Yang, Winnie; Chen, Chian Feng; Chen, Hsin‐Chang; Hwang, Betau; Chen, Mei Lien

doi:10.1016/j.scitotenv.2021.145604

Cited by 17 publications

(5 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poorer Verbal IQ in boys was associated with maternal urinary DEAPs but showed no effects in girls ( 74 ). Organophosphate exposure (pyrethroids) has been associated with attention-deficit/hyperactivity disorder frequency ( 75 ), the elevation of gonadotropin serum levels, and early puberty in boys ( 76 ). Thyroid gland diseases have been related to organophosphate exposure.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Frequency of urinary pesticides in children: a scoping review

Guzman-Torres,

Sandoval-Pinto,

Cremades

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

Pesticides are any mix of ingredients and substances used to eliminate or control unwanted vegetable or animal species recognized as plagues. Its use has been discussed in research due to the scarcity of strong scientific evidence about its health effects. International literature is still insufficient to establish a global recommendation through public policy. This study aims to explore international evidence of the presence of pesticides in urine samples from children and their effects on health through a scoping review based on the methodology described by Arksey and O‘Malley. The number of articles resulting from the keyword combination was 454, and a total of 93 manuscripts were included in the results and 22 were complementary. Keywords included in the search were: urinary, pesticide, children, and childhood. Children are exposed to pesticide residues through a fruit and vegetable intake environment and household insecticide use. Behavioral effects of neural damage, diabetes, obesity, and pulmonary function are health outcomes for children that are commonly studied. Gas and liquid chromatography-tandem mass spectrometry methods are used predominantly for metabolite-pesticide detection in urine samples. Dialkylphosphates (DAP) are common in organophosphate (OP) metabolite studies. First-morning spot samples are recommended to most accurately characterize OP dose in children. International evidence in PubMed supports that organic diets in children are successful interventions that decrease the urinary levels of pesticides. Several urinary pesticide studies were found throughout the world's population. However, there is a knowledge gap that is important to address (public policy), due to farming activities that are predominant in these territories.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Similarly, neurological and behavioral changes in children have been associated with pesticide exposure. A specific mechanism is unclear, but the main theory is that it is induced by oxidative stress and DNA damage ( 73 , 74 , 76 , 96 ).…”

Section: Resultsmentioning

confidence: 99%

Frequency of urinary pesticides in children: a scoping review

Guzman-Torres,

Sandoval-Pinto,

Cremades

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…In a case-control study on children with attention deficit/hyperactivity disorder (ADHD), GG carriers had low urinary dimethyl phosphate levels [60]. It was reported that one third of hospitalized patients with alcohol addiction have hypophosphatemia, caused by the impairment of phosphate absorption in the intestine due to alcohol consumption [61].…”

Section: Discussionmentioning

confidence: 99%

The Disease Model of Addiction: The Impact of Genetic Variability in the Oxidative Stress and Inflammation Pathways on Alcohol Dependance and Comorbid Psychosymptomatology

Tsermpini,

Goričar,

Kores Plesničar

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Oxidative stress and neuroinflammation are involved in the pathogenesis of alcohol addiction. However, little is known regarding the effect of genetic, behavioral, psychological, and environmental sources of origin on the inflammation and oxidative stress pathways of patients with alcohol addiction. Our study aimed to evaluate the impact of selected common functional single-nucleotide polymorphisms in inflammation and oxidative stress genes on alcohol addiction, and common comorbid psychosymptomatology. Our study included 89 hospitalized alcohol-addicted patients and 93 healthy individuals, all Slovenian males. Their DNA was isolated from peripheral blood and patients were genotyped for PON1 rs705379, rs705381, rs854560, and rs662, SOD2 rs4880, GPX1 rs1050450, IL1B rs1143623, rs16944, and rs1071676, IL6 rs1800795, IL6R rs2228145, and miR146a rs2910164. Kruskal–Wallis and Mann–Whitney tests were used for the additive and dominant genetic models, respectively. Our findings suggested the involvement of IL6 rs1800795 in alcohol addiction. Moreover, our data indicated that the genetic variability of SOD2 and PON1, as well as IL1B and IL6R, may be related to comorbid psychosymptomatology, revealing a potential indirect means of association of both the oxidative stress and inflammation pathways.

show abstract

“…Feng et al (2021) reported that sphingosine 1‐phosphate was a prospective prognostic biomarker regulating sepsis‐relevant events, including compromised vascular integrity, antigen presentation and cytokine secretion. Chang et al (2021) found that PGF2α was a kind of oxidative stress biomarker. Our study also suggested that the mRNA levels of Nt5c1b were down‐regulated and that the production of cytidine and 2'‐deoxyuridine decreased in American shad.…”

Section: Discussionmentioning

confidence: 99%

“…Chang et al (2021) found that PGF2α was a kind of oxidative stress biomarker. Our study also suggested that the mRNA levels of Nt5c1b were down-regulated and that the production of cytidine and 2'-deoxyuridine decreased in American shad.…”

mentioning

confidence: 99%

Long‐term exposure to enrofloxacin increases body weight and alters the metabolism of American shad ( Alosa sapidissima ) in indoor aquaculture

Liu²,

Zhang

et al. 2022

Aquaculture Research

View full text Add to dashboard Cite

The quantity of antibiotic consumption has increased steadily since the 20th century in 15 European countries (Vander Stichele et al., 2006). Approximately 100,000 and 200,000 tons of antibiotics have been produced and consumed globally per year since 2010 (Van Boeckel et al., 2014). Antibiotics enter aquatic environments through water discharge from aquaculture, human productive activity, livestock production, hospitals and pharmaceutical industries, posing a potential threat to ecosystems. ENR is a kind of antibiotic widely used as a veterinary drug and in commercial aquaculture in China (Huang et al., 2020). ENR has most frequently been detected in the water environment and animal tissues, such as farm effluents,

show abstract

The associations among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of paraoxonases in children with attention deficit/hyperactivity disorder

Cited by 17 publications

References 51 publications

Frequency of urinary pesticides in children: a scoping review

Frequency of urinary pesticides in children: a scoping review

The Disease Model of Addiction: The Impact of Genetic Variability in the Oxidative Stress and Inflammation Pathways on Alcohol Dependance and Comorbid Psychosymptomatology

Long‐term exposure to enrofloxacin increases body weight and alters the metabolism of American shad ( Alosa sapidissima ) in indoor aquaculture

Contact Info

Product

Resources

About