The Association Pattern between Ambient Temperature Change and Leukocyte Counts

Hung, Shih-Chiang; Yang, Chen-Cheng; Liu, Chu-Feng; Kung, Chia-Te; Lee, Wen-Huei; Ho, Chi-Kung; Chuang, Hung‐Yi; Yu, Hsin‐Su

doi:10.3390/ijerph18136971

Cited by 6 publications

(4 citation statements)

References 51 publications

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“…Nevertheless, it had some inevitable limitations due to its role as an inflammatory index. It is greatly affected by infections, drugs, other malignancies, hematological disease or even exercise and weather [ 21 , 22 ]. Thus, combining with other possible indicators may further improve predictive accuracy and practicality.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of systemic immune-inflammation index in the high-grade subtypes components of small-sized lung adenocarcinoma

Wei,

Zhang,

Shi

et al. 2024

J Cardiothorac Surg

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Background Identification of micropapillary and solid subtypes components in small-sized (≤ 2 cm) lung adenocarcinoma plays a crucial role in determining optimal surgical procedures. This study aims to propose a straightforward prediction method utilizing preoperative available indicators. Methods From January 2019 to July 2022, 341 consecutive patients with small-sized lung adenocarcinoma who underwent curative resection in thoracic surgery department of Xuanwu Hospital, Capital Medical University were retrospectively analyzed. The patients were divided into two groups based on whether solid or micropapillary components ≥ 5% or not (S/MP5+ and S/MP5-). Univariate analysis and multivariate logistic regression analysis were utilized to identify independent predictors of S/MP5+. Then a nomogram was constructed to intuitively show the results. Finally, the calibration curve with a 1000 bootstrap resampling and the receiver operating characteristic (ROC) curve were depicted to evaluate its performance. Results According to postoperative pathological results, 79 (23.2%) patients were confirmed as S/MP5+ while 262 (76.8%) patients were S/MP5-. Based on multivariate analysis, maximum diameter (p = 0.010), consolidation tumor ratio (CTR) (p < 0.001) and systemic immune-inflammation index (SII) (p < 0.001) were identified as three independent risk factors and incorporated into the nomogram. The calibration curve showed good concordance between the predicted and actual probability of S/MP5+. Besides, the model showed certain discrimination, with an area under ROC curve of 0.893. Conclusions The model constructed based on SII is a practical tool to predict high-grade subtypes components of small-sized lung adenocarcinoma preoperatively and contribute to determine the optimal surgical approach.

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Section: Discussionmentioning

confidence: 99%

Predictive value of systemic immune-inflammation index in the high-grade subtypes components of small-sized lung adenocarcinoma

Wei,

Zhang,

Shi

et al. 2024

J Cardiothorac Surg

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“…Temperature can affect blood biomarkers of coagulation and inflammation [ 15 ]. The relationship between environmental temperature and white blood cell (WBC) count shows a V-shaped curve, and when the temperature difference between adjacent days is large, WBC levels also increase [ 16 ]. Acute heat exposure can cause an increase in hematocrit, while chronic heat exposure can cause a decrease [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of heat waves and cold spells on blood parameters: a cohort study of blood donors in Tianjin, China

Gao,

Liu,

et al. 2024

Environ. Health Prev. Med.

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Background With the increasing occurrence of extreme temperature events due to climate change, the attention has been predominantly focused on the effects of heat waves and cold spells on morbidity and mortality. However, the influence of these temperature extremes on blood parameters has been overlooked. Methods We conducted a cohort study involving 2,752 adult blood donors in Tianjin, China, between January 18, 2013, and June 25, 2021. The generalized additive mixed model was used to investigate the effects and lagged effects of heat waves and cold spells on six blood parameters of blood donors, including alanine aminotransferase (ALT), white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HB), hematocrit (HCT), and platelet count (PLT). Subgroup analyses were stratified by sex, age, and BMI. Results Heat waves and cold spells are associated with changes in blood parameters, particularly HB and PLT. Heat waves increased HB and PLT, while cold spells increased HB and decreased PLT. The effect of heat waves is greater than that of cold spells. The largest effect of heat waves on HB and PLT occurred at lag1 with 2.6 g/L (95% CI : 1.76 to 3.45) and lag7 with 9.71 × 10^9/L (95% CI : 6.26 to 13.17), respectively, while the largest effect of cold spells on HB and PLT occurred at lag0 with 1.02 g/L (95% CI : 0.71 to 1.33) and lag2 with −3.85 × 10^9/L (95% CI : −5.00 to −2.70), respectively. In subgroup analysis, the effect of cold spells on ALT was greater in the 40–49 age group. Conclusion We indicated that heat waves and cold spells can impact hemoglobin and platelet counts in the human body. These findings provide evidence linking heat waves or cold spells to diseases and may reduce health risks caused by extreme temperature events. Supplementary information The online version contains supplementary material available at https://doi.org/10.1265/ehpm.24-00023 .

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“…Indoor and outdoor air temperature is one of the factors affecting human health. 1,2 Changes in environmental temperature have wide-ranging effects on human health, including cardiovascular, respiratory and mortality from infectious diseases. 3 Amongst them, respiratory diseases are one of the important causes for death and disability.…”

Section: Introductionmentioning

confidence: 99%

Effects of the air temperature on immunoglobulin concentrations of healthy people

Liu

et al. 2023

Indoor and Built Environment

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The air temperature was critical to human health, especially for the mucosal immunity of the respiratory system. Amongst a few biomarkers, immunoglobulin was an effective material to evaluate respiratory health. In order to explore the effects of the natural air temperature on serum immunoglobulin concentrations of people, an epidemiological investigation was conducted between Jan 2018 and Dec 2019. In addition, an experiment was conducted to find the relationship between indoor air temperature and salivary immunoglobulin E (IgE) concentration, under the built environment within the comfort zone of people. Results of the epidemiological investigation showed that the serum IgE concentration was the most sensitive to temperature and was positively correlated with outdoor environmental temperature ( p < 0.001, Spearman = 0.509). In addition, the experimental results showed that the salivary IgE concentration was also positively correlated with indoor temperature ( p = 0.009, Spearman = 0.495), and it rose significantly with the increase of thermal comfort votes ( p = 0.022, Spearman = 0.508). In a comfortable temperature range, keeping a higher air temperature can increase the concentration of IgE antibodies, which is one of the ways to improve the mucosal immunity of the respiratory system.

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The Association Pattern between Ambient Temperature Change and Leukocyte Counts

Cited by 6 publications

References 51 publications

Predictive value of systemic immune-inflammation index in the high-grade subtypes components of small-sized lung adenocarcinoma

Predictive value of systemic immune-inflammation index in the high-grade subtypes components of small-sized lung adenocarcinoma

Effects of heat waves and cold spells on blood parameters: a cohort study of blood donors in Tianjin, China

Effects of the air temperature on immunoglobulin concentrations of healthy people

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