The association of vitamin D status with cardiometabolic risk factors, obesity and puberty in children

Aypak, Cenk; Türedi, Özlem; Yüce, Adnan

doi:10.1007/s00431-013-2177-2

Cited by 41 publications

(43 citation statements)

References 62 publications

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“…As in our results, some other studies have shown negative associations between pubertal status and serum 25(OH)D concentration in both sexes (15,18,37,38) , although increasing age, lesser outdoor sport and greater demands on vitamin D stores for skeletal mineralization could contribute to this finding (17,39) . It is necessary to consider pubertal stage as it is associated with a remarkable change in the lifestyle of children in terms of daily sun exposure and outdoor physical activity; clothing and percentage of body surface area exposed may contribute significantly to change in 25(OH)D concentration in this stage (40) .…”

Section: Pubertysupporting

confidence: 44%

Vitamin D deficiency and its associated risk factors in children and adolescents in southern Iran

Saki

Dabbaghmanesh

Bakhshayeshkaram

2015

Public Health Nutr.

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Objectives: To evaluate prevalence of vitamin D deficiency and its associated factors in southern Iranian children. Design: Cross-sectional study. Anthropometric and pubertal characteristics were assessed by a trained physician. Physical activity and sun exposure were evaluated using standard questionnaires. Body composition measurements were performed using dual-energy X-ray absorptiometry. Serum Ca, P alkaline phosphatase and 25-hydroxyvitamin D (25(OH)D) were assessed in all children. Statistical analysis was done using the statistical software package IBM SPSS Statistics 18·0. Subjects: Iranian children (n 477) aged 9-18 years. Setting: Fars Province, Iran, 2011. Results: Of the children, 81·3 % were 25(OH)D deficient. There was no significant difference in 25(OH)D concentration between boys and girls (P = 0·3). 25(OH)D concentration was associated with BMI (r = − 0·1, P = 0·02), pubertal status (r = − 0·08, P = 0·04) and sun exposure (r = 0·10, P = 0·04). Fat mass index was associated with 25(OH)D concentration (r = − 0·13, P = 0·03), but not lean mass index (P = 0·86). In multiple regression analysis with adjustment for confounding factors, age and puberty were found to be independently associated with 25(OH)D concentration (P = 0·008 and P = 0·006); there was a significant correlation between exercise and 25(OH)D concentration after adjustment for either BMI (P = 0·01) or fat mass index (P = 0·02). Conclusions: 25(OH)D deficiency is highly prevalent among children in the south of Iran. It is related to insufficient sun exposure, low physical activity, advancing age and pubertal stage. Measures should be taken to improve the health of southern Iranian children in this critical age group by preventing 25(OH)D deficiency.

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Section: Pubertysupporting

confidence: 44%

Vitamin D deficiency and its associated risk factors in children and adolescents in southern Iran

Saki

Dabbaghmanesh

Bakhshayeshkaram

2015

Public Health Nutr.

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“…Many obese children present with low blood concentrations of vitamin D [7–9], probably due to its insufficient dietary intake and too small amount of outdoor physical activity [10, 11]. Also greater fat mass seems to be associated with lower blood concentration of vitamin D, which may, at least partially, result from sequestration of this vitamin in adipose tissue [12].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies documented inverse relationships between blood concentration of vitamin D, waist circumference, systolic blood pressure, insulin resistance, fasting glycaemia, total cholesterol, triglyceride and LDL cholesterol levels in paediatric subjects, as well as positive associations between concentrations of vitamin D and HDL cholesterol [7, 14, 15]. Vitamin D seems to interfere with insulin secretion both directly, binding to its receptors (VDR) on pancreatic β cells, and indirectly, modulating extracellular concentration of calcium [16].…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme (a double-blind placebo-controlled study) – rationale for the study design

Szlagatys-Sidorkiewicz

Brzeziński

Jankowska

et al. 2017

BMC Pediatr

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BackgroundObesity is associated not only with an array of metabolic disorders (e.g. insulin resistance, hiperinsulinemia, impaired tolerance of glucose, lipid disorders) but also skeletal and joint abnormalities. Recently, a pleiotropic role of vitamin D has been emphasized. Obese children frequently present with vitamin D deficiency, and greater fat mass is associated with lower serum concentration of this vitamin. Although some evidence suggests that weight loss may affect vitamin D status, this issue has not been studied extensively thus far. The aim of a double-blind placebo-controlled study is to assess long-term health effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme.MethodsA randomized double-blind, placebo-controlled trial analysing the effects of vitamin D3 supplementation in overweight or obese vitamin D deficient (<30 ng/ml) children participating in an integrated weight-loss programme. Children are randomized to receive either vitamin D (1200 IU) or placebo for 26 weeks. Primary endpoints include changes in BMI (body mass index), body composition and bone mineral density at the end of the study period, and secondary endpoints – the changes in laboratory parameter reflecting liver and kidney function (transaminases, creatinine) and glucose homeostasis (glucose and insulin levels during oral glucose tolerance test).DiscussionThe effects of vitamin D supplementation in obese individuals, especially children, subjected to a weight-loss program are still poorly understood. Considering physiological processes associated with puberty and adolescent growth, we speculate that supplementation may enhance weight reduction and prevent bone loss in obese children deficient in this vitamin.Trial registration NCT 02828228; Trial registration date: 8 Jun 2016; Registered in: ClinicalTrials.gov. The trial was registered retrospectively.

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“…In a large-scaled study involving 2,488 adults, both seasonal variation and severe deficiency were detected (14). In a small-scaled study involving 391 individuals, a statistically significant relationship was reported between cloths and deficiency (15).…”

Section: Resultsmentioning

confidence: 94%

The prevalence of vitamin D deficiency-insufficiency in medical faculty students

Sevimli¹,

Yakıncı²,

Encan³

et al. 2018

J Turgut Ozal Med Cent

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Aim: The vitamin D deficiency is a pandemic health problem due to worldwide modernization. We tried to determine the impact of the reduced sun exposure on the vitamin D levels of the medical faculty students due to the long study hours and indoor study environment and classrooms. Material and Method: Two-hundred and eleven (113 women, 98 men) medical faculty students were included in the study. Blood samples were obtained from the students and serum 25 hydroxyvitamin D3 levels were measured on the same day. Students were healthy individuals, aged 17-29 years (mean age= 19 years). Data were analyzed using SPSS software program. The frequency distribution of the qualitative data and arithmetic mean, minimum, maximum and standard deviation of the quantitative data were used to define descriptive statistics. Non-parametric tests and Chi-square test were used for the analysis of qualitative data; the analysis of the quantitative data was done by observing normally distributed data. The significance level of Chi-square test, independent-student t-test and Mann-Whitney U test were accepted as p≤0.05. Results: Serum 25 hydroxyvitamin D3 levels was below 20 ng/ml in 56% (n=118) of the students, of which 72% (n=85) were women. Conclusion: Especially, women had high levels of vitamin D deficiency in our study. This high ratio gives rise to thought that women spend more of their time indoor spaces due to modernization., women are exposed to sun light less than men, and thus they have higher levels of vitamin D deficiency.

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The association of vitamin D status with cardiometabolic risk factors, obesity and puberty in children

Abstract: The association between vitamin D status and BMI is complex, and it does not seem to be altered by mild obesity. In addition, potential influence of puberty should be kept in mind while assessing the relationship between serum 25(OH)D and cardiometabolic risk factors.

Cited by 41 publications

References 62 publications

Vitamin D deficiency and its associated risk factors in children and adolescents in southern Iran

Vitamin D deficiency and its associated risk factors in children and adolescents in southern Iran

Long-term effects of vitamin D supplementation in vitamin D deficient obese children participating in an integrated weight-loss programme (a double-blind placebo-controlled study) – rationale for the study design

The prevalence of vitamin D deficiency-insufficiency in medical faculty students

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