The Association of Vitamin D Levels with Common Pregnancy Complications

Dovnik, Andraž; Mujezinović, Faris

doi:10.3390/nu10070867

Cited by 57 publications

(60 citation statements)

References 93 publications

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“…Nearly half of these women had vitamin D intakes below the EAR, even with supplementation [71], highlighting the need for increased attention to vitamin D supplementation in pregnant women. In pregnancy, vitamin D deficiency increases the risk of placental insufficiency and preeclampsia, is associated with increased risk of bacterial vaginosis, and increases the risk of developing gestational type 2 diabetes (T2D) by increasing glucose intolerance [113,117,118].…”

Section: Vitamin Dmentioning

confidence: 99%

Nutritional Gaps and Supplementation in the First 1000 Days

Korczak²,

et al. 2019

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Optimized nutrition during the first 1000 days (from conception through the 2nd birthday) is critical for healthy development and a healthy life for the newborn. Pregnancy and the postpartum period are accompanied by physiological changes, increased energy needs, and changing requirements in the nutrients critical for optimal growth and development. Infants and toddlers also experience physiological changes and have specific nutritional needs. Food and nutrition experts can provide women of childbearing age with adequate dietary advice to optimize nutrition, as well as guidance on selecting appropriate dietary supplements. Considering the approaching 2020–2025 Dietary Guidelines for Americans (DGA) will be making specific recommendations for children, it is important to provide accurate scientific information to support health influencers in the field of nutrition. The purpose of this review is to summarize the nutrition and supplementation literature for the first 1000 days; to highlight nutritional and knowledge gaps; and to educate nutrition influencers to provide thoughtful guidance to mothers and families. Optimal nutrition during pregnancy through early childhood is critical for supporting a healthy life. Nutrition influencers, such as dietitians, obstetricians/gynecologists, and other relevant health professionals, should continue guiding supplement and food intake and work closely with expectant families and nutrition gatekeepers.

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Section: Vitamin Dmentioning

confidence: 99%

Nutritional Gaps and Supplementation in the First 1000 Days

Korczak²,

et al. 2019

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“…Consequently, vitamin D deficiency is associated with increased rates of fetal miscarriage, preeclampsia, gestational diabetes, and impaired fetal and childhood growth and development [56]. On the other hand, vitamin D can also affect the pathophysiology of preterm birth by affecting inflammatory and immunomodulatory processes [59]. It is responsible for initiating the adequate function of toll-like receptors in innate immune responses.…”

Section: Discussionmentioning

confidence: 99%

Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

Lian

et al. 2020

Preprint

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Background: Current studies suggest that vitamin D deficiency during pregnancy can produce a certain effect for preterm birth, but there is no research showing whether vitamin D deficiency has a consistent effect in different pregnancies; thus, we conducted a systematic review and meta-analysis of 24 observational studies, grouping them according to the gestational age at the time of serum sampling, to investigate whether vitamin D deficiency in different periods of gestation has different effects on preterm birth and to provide an evidence-based basis for pregnant women to measure and supplement vitamin D. Methods: The databases PubMed-Medline, EMBASE, the Cochrane Library, Web of Science, EBSCO, CBM, and CNKI were searched until July 2019. Two researchers independently assessed the eligibility and quality of studies, and STATA 12.0 software was used for meta-analysis. Result: Seven cohort studies, 13 case-control studies, and four cross-sectional studies were included from 2500 articles by inclusion and exclusion criteria. After adjusting for age, race, and other confounding factors, meta-analysis results showed that vitamin D deficiency in the first trimester, the second trimester and the third trimester did not increase the risk of preterm birth (odds ratio (OR) = 1.01, 95% confidence interval (CI) (0.88, 1.16), P = 0.867; OR = 1.12, 95%CI (0.92, 1.37), P = 0.249; OR = 1.05, 95%CI (0.87, 1.27), P = 0.602). However, there was moderate heterogeneity in the study of vitamin D deficiency in the second trimester, and subgroup analysis suggested that vitamin D deficiency in the second trimester may increase the risk of preterm birth (OR = 1.33, 95%CI (1.15, 1.54), P = 0.000). A sensitivity analysis of the second trimester showed that excluding any one study did not significantly change the results. Conclusions: Vitamin D deficiency in early and late pregnancy may not be associated with preterm birth, while vitamin D deficiency in middle pregnancy is likely to have an important effect on preterm birth. Vitamin D levels should be measured in the second trimester of pregnancy, and vitamin D supplements should be provided if necessary.

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“…Hence, obese women have an even higher prevalence of vitamin D deficiency during pregnancy. Recently, the RCOG guidelines recommended that obese pregnant women should be taking at least 1000 units a day of vitamin D supplementation, compared with a daily vitamin D supplementation of 400 units for those women with healthy BMI [60,64].…”

Section: Management Of Vitamin D Deficiency During Pregnancymentioning

confidence: 99%

Undernutrition during Pregnancy

Nguyen¹

2019

Complications of Pregnancy

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Experience in being pregnant is exciting but is very challenging. The term "undernutrition," as used in this chapter, focuses more on inadequate intake of energy and nutrients to meet the desired outcome of a healthy mother and her baby. Evidence shows that women with undernutrition before and during pregnancy have increased risk of metabolic disorders (i.e., gestational diabetes mellitus) and are at increased risk of complications during labor and birth. To date, nutritional therapies promoting healthier pregnancies fall into the following two major categories: (1) management of gestational weight gain and (2) the prevention or treatment of nutrient deficiencies related to pregnancy. A literature search on PubMed, the Cochrane library, Google scholar, and Cumulative Index of Nursing and Allied Health Literature was conducted to identify the relevant nutritional therapies. As a result, this chapter will analyze and discuss gestational weight gain and its effect on the health of women and her baby. The chapter briefly proposes evidence-based nutritional therapy for gestational diabetes as well as gestational common nutrient imbalance, such as vitamin D, folic acid, and omega-3 docosahexaenoic acid deficiency. The recommendations, in this chapter, would be a partial answer for these problems in Asia.

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The Association of Vitamin D Levels with Common Pregnancy Complications

Cited by 57 publications

References 93 publications

Nutritional Gaps and Supplementation in the First 1000 Days

Nutritional Gaps and Supplementation in the First 1000 Days

Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

Undernutrition during Pregnancy

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