The association of vaspin rs2236242 and leptin rs7799039 polymorphism with metabolic syndrome in Egyptian women

Abstract

Background/aim: Genetic predisposition is implicated in the etiology of metabolic syndrome. This study aimed to investigate the association of vaspin rs2236242 and leptin rs7799039 polymorphisms with their serum levels and with the risk of developing metabolic syndrome in Egyptian women. Materials and methods:This case control study included 100 Egyptian women with metabolic syndrome and 100 without metabolic syndrome. The genotypes of vaspin rs2236242 and leptin rs7799039 were detected by a methodology based on PCR-RFLP. Serum vaspin and leptin levels were determined by ELISA. Results:The metabolic syndrome group was associated with higher serum vaspin and leptin levels when compared to the nonmetabolic syndrome group. The AA genotype of leptin rs7799039 was associated with metabolic syndrome and with higher serum leptin levels, while the different genotypes of vaspin rs2236242 were not associated with metabolic syndrome or different serum vaspin levels. Conclusion:The AA genotype of leptin rs7799039 was associated with metabolic syndrome and higher serum leptin levels. Serum leptin and vaspin can be used as diagnostic markers of metabolic syndrome.

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

“…Opposing results were published by Alnory et al They showed no significant difference in the allele and genotype frequency of vaspin rs2236242 polymorphism between the MetS and non-MetS groups. In addition, no significant difference in the vaspin levels between different polymorphic forms of vaspin rs2236242 was detected [78].…”

“…Significantly higher serum levels of vaspin were observed in patients with MetS (3.34 ±0.52 ng/ml) in comparison to non-MetS cases (1.87 ±0.54 ng/ml). The researchers concluded that serum vaspin concentrations can be used as diagnostic markers of metabolic syndrome [78]. Other researchers have demonstrated that non-alcoholic fatty liver disease and related entities, found in as many as 90% of subjects with MetS, have also been associated with an elevated levels of serum vaspin [79].…”

Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients

“… 38 In addition, AA genotype was associated with higher risk of malnutrition inflammation syndrome, 24 obesity 25 and metabolic syndrome. 26 On the other hand, the CC genotype has been shown to be associated with dyslipidemia in patients using atypical antipsychotic agents. 29 Finally, rs7799039 is known to impact body weight, 27 , 43 susceptibility to diseases 26 , 44 – 46 and response to treatments.…”

“…The clinical significance of this polymorphism is well documented as it was associated with higher risk of several diseases including malnutrition inflammation syndrome, 24 obesity 25 and metabolic syndrome. 26 In addition, rs7799039 was associated with blood lipid levels among Southern Chilean population, 27 dyslipidemia in patients using atypical antipsychotic agents and lipid profile modulation induced by soluble fiber intake. 28 , 29 In the current study, we examined the impact of leptin gene polymorphism (rs7799039) on lipid profile alterations as adverse effects of isotretinoin in acne patients.…”

Clinical update on metabolic syndrome

“…Particularly, Alnory et al 20 studied the influence of specific polymorphisms in leptin and vaspin blood levels and the risk of suffering MS. A genotype of leptin polymorphisms was associated with metabolic risk development and high leptin concentration. Another study 21 found that specific variations in FTO, SCG3 and MTMR9 genes could increase risk of MS. More recently, Zhao et al 22 refuted associations between genetic variations and MS.…”