The association of vascular endothelial growth factor polymorphism (rs699947) with diabetic foot ulcer and oxidative status

Ahmed, Saja Talib; Ewadh, Mufeed J.; Jeddoa, Zuhair Mohammed Ali

doi:10.1016/j.genrep.2020.100606

Cited by 4 publications

(5 citation statements)

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“…This study showed that the A/C genotype especially the C allele significantly raised the risk of DFU (Ahmed et al, 2020). According to this study; the alteration in the VEGF sequence due to polymorphism led to an increase in the oxidative stress and decrease in antioxidant glutathione (GSH) which lead to an increase in the risk for DFU (Ahmed et al, 2020). Another association was found between the VEGF polymorphism at position -2578*C/A and DFU located at the minor allele (A) and conferred a protective effect from DFU (Kuo et al, 2016).…”

Section: Types Of Polymorphisms Associated With Dfumentioning

confidence: 60%

“…In addition, a significant association was found between the VEGF polymorphism (rs699947) and DFU In an Iraqi study that investigated the molecular basis of the SNP (rs699947) and its correlation with biochemical parameters, such as glycated hemoglobin (HbA1c) and glutathione (GSH). This study showed that the A/C genotype especially the C allele significantly raised the risk of DFU (Ahmed et al, 2020). According to this study; the alteration in the VEGF sequence due to polymorphism led to an increase in the oxidative stress and decrease in antioxidant glutathione (GSH) which lead to an increase in the risk for DFU (Ahmed et al, 2020).…”

Section: Types Of Polymorphisms Associated With Dfumentioning

confidence: 91%

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Genetic polymorphisms associated with diabetic foot ulcer: A review article

Mohammed¹,

Jasim²

2020

Asian J Pharm Pharmacol

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Recently, microRNAs (miRNAs) which are non-coding small RNAs that negatively control gene expressions displayed an important role in the regulation of gene expression in various cells of the skin, including stem cells, immune cells, and keratinocytes (Xu et al., 2014). Moreover, several miRNAs were shown to be differentially expressed in diabetic skins and their expression levels varied during the wound healing process (Madhyastha et al., 2012). For instance, miRNA-126 depletion causes defective endothelial cell proliferation, migration, and angiogenesis contributed by elevated levels of miRNA-503 which is specially grown in diabetes resulting in impaired wound healing via persistent

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Section: Types Of Polymorphisms Associated With Dfumentioning

confidence: 60%

Section: Types Of Polymorphisms Associated With Dfumentioning

confidence: 91%

Genetic polymorphisms associated with diabetic foot ulcer: A review article

Mohammed¹,

Jasim²

2020

Asian J Pharm Pharmacol

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“…33 Various studies regarding antioxidant enzymatic and non-enzymatic have been done in clinical investigations of different Iraqi patients. 34,35 Our study chose two types of antioxidant enzymes (catalyze and glutathione peroxidase), to study their levels in the blood serum of the two study groups and their relationship with the levels of PAHs for both groups, found low levels in the levels of both catalase and glutathione peroxidase enzymes in the blood serum of traffic police personnel deployed in Baghdad city intersections compared to the levels of the two enzymes were in the control group represented by the office police, and the levels of these enzymes were inversely proportional to the levels of pollutants in the blood serum represented by polycyclic aromatic hydrocarbons. Also, some studies conducted to evaluate the effects of occupational exposure to pollutants on oxidative stress in the body have indicated a decrease in the levels of antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

Effect of pollution represented by Polycyclic Aromatic Hydrocarbons on the levels of p53 and some antioxidant enzymes in Baghdad traffic police

Salem¹,

Al-Wasiti

Hasan

2022

J. Contemp. Med. Sci.

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Objectives: To ascertain the protective effect of p53 tumor protein by monitoring its levels in comparison with the levels of antioxidant enzymes, against any type of cancer that can be caused by chronic exposure of traffic policemen to air pollutants. Methods: This study comprises 140 participants, who have been divided into two groups (Traffic police and Office police). PAHs were analyzed for each participant by GC/FID while p53 protein and antioxidant enzymes were measured by the ELISA technique. Results: The concentrations of polycyclic aromatic hydrocarbons and p53 tumor protein were high in the blood of traffic police compared to office police, while higher levels of antioxidant enzymes (Catalase and G-Px) were observed in the blood of office police. Conclusion: Exposure to PAHs can cause oxidative stress, which can damage DNA and lead to cancer. However, because natural endogenous biomolecules like p53 protein can neutralize PAHs' carcinogenic effects, their elevation has a beneficial anti-cancer effect by reducing oxidative stress and preventing tumorigenesis.

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“…In previous studies, especially in Asian population, rs699947 polymorphism was signi cantly associated with increased risk of bladder cancer and renal cell carcinoma [33]. In addition, bladder cancer [34], diabetic foot [35], multiple sclerosis [36], and cervical cancer [28] were mostly associated with rs699947: rs699947, as the promoter region site, was considered to be signi cantly correlated with the serum VEGF content in patients with cervical cancer. The CC type was signi cantly higher than that of AC and AA types, and the short-term e cacy of radiotherapy was lower than that of AC and AA types, but the incidence of adverse reactions was lower than that of AC type.…”

Section: Comparison Of Genotype and Allele Frequencies Of Vegf Gene R...mentioning

confidence: 99%

VEGF Gene Polymorphism And Study On Genetic Susceptibility Of Neuropsychiatric Lupus

Yang,

Jin,

Liu

et al. 2024

Preprint

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Background: Vascular endothelial growth factor ( VEGF ) plays an important role in the pathogenesis of neuropsychiatric lupus ( NPSLE ), This study was designed for analysis of the relationship between single nucleotide polymorphisms of VEGF gene rs699947, rs10434, rs833070 and genetic susceptibility to NPSLE. Methods: A total of 82 patients diagnosed as NPSLE and without other autoimmune diseases were selected as the NPSLE group (positive group). Non-NPSLE group (positive control group) 166 patients with systemic lupus erythematosus without psychiatric symptoms. According to the principle of age matching with the positive control group, 150 healthy subjects were randomly selectedas the healthy control group (negative control group). The allele and genotype of three SNP loci and the correlation between NPSLE and non-NPSLE were analyzed. Results: 1. The genotype frequencies of GG, GA and AA genotypesat rs10434 locus were statistically significant in NPSLE group, non-NPSLE group and negative control group (P < 0.05). 2. The genotype and allele frequencies of rs699947 and rs833070 loci werenot statistically significant in the NPSLE group, non-NPSLE group and negative control group (P > 0.05). 3. rs10434 locus GG genotype and G gene as reference, A allele, mutant heterozygous model GA, dominant model (GA+AA ) were associated with therisk of NPSLE (P < 0.05). Conclusion: We found that VEGF rs10434 A allele, mutant heterozygous model GA, dominant model GA+AA can increase the risk of NPSLE. A allele and dominant model GA+AA can increase the risk of non-NPSLE. There was no significant correlation between rs699947 and rs833070 polymorphism and the risk of NPSLE and non-NPSLE.

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The association of vascular endothelial growth factor polymorphism (rs699947) with diabetic foot ulcer and oxidative status

Cited by 4 publications

References 28 publications

Genetic polymorphisms associated with diabetic foot ulcer: A review article

Genetic polymorphisms associated with diabetic foot ulcer: A review article

Effect of pollution represented by Polycyclic Aromatic Hydrocarbons on the levels of p53 and some antioxidant enzymes in Baghdad traffic police

VEGF Gene Polymorphism And Study On Genetic Susceptibility Of Neuropsychiatric Lupus

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